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Now researchers report that they have used artificial intelligence to discover a new class of antibiotic candidates. A team at the laboratory of James Collins of the Broad Institute of the Massachusetts Institute of Technology and Harvard University used a type of AI known as deep learning to screen millions of compounds for antibiotic activity. They then tested 283 promising compounds in mice and found several that were effective against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci—some of the most stubbornly hard-to-kill pathogens. Unlike a typical AI model, which operates as an inscrutable “black box,” it was possible to follow this model’s reasoning and understand the biochemistry behind it.

Siri also had a cumbersome design that made it time-consuming to add new features, said Mr. Burkey, who was given the job of improving Siri in 2014. Siri’s database contains a gigantic list of words, including the names of musical artists and locations like restaurants, in nearly two dozen languages.That made it “one big snowball,” he said. If someone wanted to add a word to Siri’s database, he added, “it goes in one big pile.”So seemingly simple updates, like adding some new phrases to the data set, would require rebuilding the entire database, which could take up to six weeks, Mr. Burkey said. Adding more complex features like new search tools could take nearly a year. That meant there was no path for Siri to become a creative assistant like ChatGPT, he said.

Resist being context-collapsed to a one-dimensional being.

Technologists intervene in our present realities and forge the future, and in doing so, choose how best to model the world and impress their will upon it. The public must insist that technologists are responsible for thinking about the human implications of their work.

You will find in every case that these technologies were only possible because of active decisions taken by governments, corporations, and individuals. They never just “happened”, whatever that might mean. People make history happen, and by reading history, you can see yourself as one of those people. What better motivation could there be for working to make things happen yourself?

The umwelt theory states that the mind and the world are inseparable because it is the mind that interprets the world for the organism. Because of the individuality and uniqueness of the history of every single organism, the umwelten of different organisms differ.

Much of these problems with Google today stem from a lack of visionary leadership from Sundar Pichai, and his clear lack of interest in maintaining the cultural norms of early Google. A symptom of this is the spreading contingent of inept middle management. Take Jeanine Banks, for example, who manages the department that somewhat arbitrarily contains (among other things) Flutter, Dart, Go, and Firebase. Her department nominally has a strategy, but I couldn't leak it if I wanted to; I literally could never figure out what any part of it meant, even after years of hearing her describe it. Her understanding of what her teams are doing is minimal at best; she frequently makes requests that are completely incoherent and inapplicable. She treats engineers as commodities in a way that is dehumanising, reassigning people against their will in ways that have no relationship to their skill set. She is completely unable to receive constructive feedback (as in, she literally doesn't even acknowledge it). I hear other teams (who have leaders more politically savvy than I) have learned how to "handle" her to keep her off their backs, feeding her just the right information at the right time. Having seen Google at its best, I find this new reality depressing.

The Ai Pin makes the same conceptual mistake behind all the assistants that preceded it: to treat all people as if they were so utterly helpless and clueless to manage even basic stuff. And to grossly miscalculate which tasks people find tedious and willing to delegate to a machine. These assistants want to assist with stuff people have no problem doing themselves, and they do so through an interaction model that ultimately makes things more awkward, impractical, and longer to accomplish. (On the other hand, it’s a good interaction model for people who have different types of motoric or visual disabilities and need assistance when sending and receiving messages, collecting information, etc.).

Instead there’s this urge to create The Next Big Thing that will be a hit for everyone, everywhere. And to create it in one fell swoop, skipping all the steps that might help you really get there.

Once you come to the realization/acceptance that no one – not even the interested, motivated, and committed — has the kind of focused attention available for your thing that you assume they have, you will have a much better chance of capturing and sustaining any of it at all.

Ask as few actions of your audience as possible, and provide as little information to support those actions as possible. Everything else that you could put on your screen is a distraction.

I like to break down reality into different layers. There’s physical reality, biological reality, social reality, and emotional reality.

“Physical reality” includes not just abstract theories about physics but also our embodied intuitions of how the physical world works, e.g. that I can’t walk through a wall, travel backwards in time, or move clouds with my mind. These are assumptions I need not test repeatedly to see whether they’re still true

It’s safe to assume that you are going to age and die and that you need food and water to survive. But the parameters can be tuned quite a bit—some people get by with extreme fasting or very little sleep, and plenty of people think we’ll eventually cure aging, cancer, and other biological problems.

Social and emotional reality are the most malleable, and I think these are the areas where people take too many things for granted.

Remember that all of our rules, laws, and social conventions are made up. Even the literal concept of a corridor is something that a guy came up with in 1597.

it’s not just that there are exceptions to the pattern, it’s that the pattern applies to people in the past, and social reality is always changing. In particular, social reality is changing more quickly than ever because of the internet. Most people still don’t appreciate how much power the internet gives us: for accessing information, for sharing ideas, for connecting with people who share your interests and goals.

Examples of social realities that people take for granted but which are subject to change (and have already changed a lot): I need to go to college in order to have a well-paying career I need to pay for a course in order to learn about X The broadest form of this is “I need permission from someone with authority in order to do what I want to do”. I guess we can be forgiven for believing this, since this is what elementary school looked like for many of us: you had to get a hall pass in order to leave the classroom to drink water. So of course you’ll believe that “getting permission” is the default mode of navigating the world.

Tumblr has attempted a variety of new monetization strategies, including Live, a sponsored post feature called Blaze, an ad-free subscription, and a paid content feature called Post Plus. Their success has apparently been mixed. Mullenweg called Post Plus the subject of a viral “misinformation” campaign that suggested monetizing fan content could lead to lawsuits, producing a backlash that included — Mullenweg said — threats against creators who used it. “Since then we’ve gotten better at managing attacks and threats, with new tools and a bigger Trust & Safety team, but Post Plus never recovered,” he said.

it seems that by the time men begin dating, they are relatively “limited in their ability and willingness to be fully emotionally present and available,” he said.Navigating interpersonal relationships in a time of evolving gender norms and expectations “requires a level of emotional sensitivity that I think some men probably just lack, or they don’t have the experience,” he added. He had recently read about a high school creative writing assignment in which boys and girls were asked to imagine a day from the perspective of the opposite sex. While girls wrote detailed essays showing they had already spent significant time thinking about the subject, many boys simply refused to do the exercise or did so resentfully. Mr. Cox likened that to heterosexual relationships today: “The girls do extra, and the boys do little or nothing.”

It also showed how efforts to suppress such information can backfire. Many of the videos on TikTok were posted after the British newspaper the Guardian, which had hosted a copy of bin Laden’s letter, removed it. Some TikTokers said the removal was proof of the letter’s wisdom and importance, leading them to further amplify it as a result.“Don’t turn the long-public ravings of a terrorist into forbidden knowledge, something people feel excited to go rediscover,” Renee DiResta, a research manager at the Stanford internet Observatory who has advised Congress on online disinformation, wrote Thursday in a post on Threads. “Let people read the murderer’s demands — this is the man some TikTok fools chose to glorify. Add more context.”

the letter didn’t rank among TikTok’s top trends. Videos with the #lettertoamerica hashtag had been seen about 2 million times — a relatively low count on a wildly popular app with 150 million accounts in the United States alone.Then that evening, the journalist Yashar Ali shared a compilation he’d made of the TikTok videos in a post on X, formerly Twitter. That post has been viewed more than 28 million times. By Thursday afternoon, when TikTok announced it had banned the hashtag and dozens of similar variations, TikTok videos tagged #lettertoamerica had gained more than 15 million views.

now it’s three years later, and look around: First, we had two years of inflation news. Now, there is war in the air. A prolonged conflict in Ukraine and instability in Europe. Hamas’ attack on Israel, disturbing images out of Gaza, and a hot debate about U.S. support for Israel’s military. Headlines are everywhere about the growing specter of China invading Taiwan and the Iran-Russia alignment. On top of that, there’s a migrant crisis at the border and in some major U.S. cities. And, once again, protests abound — this time pro-Israel and pro-Palestine protests on college campuses and in urban areas.

the market didn’t so much pull ChatGPT out of OpenAI as they pulled the ambition to be a consumer tech company out of a group of researchers.

the tech keynote has diminished in importance and, in the case of Apple, disappeared completely, replaced by a pre-recorded marketing video. I want to be mad about it, but it makes sense: an iPhone introduction has been diminished not by Apple’s presentation, but rather Apple’s presentations reflect the reality that the most important questions around an iPhone are about marketing tactics. How do you segment the iPhone line? How do you price? What sort of brand affinity are you seeking to build?

“While history is often written about with great authority, the reality is that history by its nature is inherently anecdotal,” Weaver says. “We've had an opportunity to interview the people who actually created an entire industry, in their own words. Long after all of us are dead, the future of our industry is cemented in the words of the people who created it.”

She said it's not about just teaching facts, dates and timelines. To teach the book properly, she says she would need her students to delve into why the murders took place. And that, she says, involves talking about race and gender."When you look at it as literature, instead of looking at facts and dates and timelines, you're looking instead at why it's still impactful and what in society at the time actually allowed that to happen," Thoreson said. "Literature is about humanity — why is this story heartbreaking? What is it about this story that draws people in? Why do we still care? You know, what is the connection today? Have those relationships between races changed?"

Israel’s intense bombardment of Gaza began on Oct. 7 in response to a surprise attack by Hamas that killed roughly 1,400 people in Israel. Since then, Gazans have found that nowhere is safe, as homes, mosques, schools and hospitals have been struck. More than 3,500 Palestinians have been killed since the strikes began, according to the Gaza health ministry.

On Saturday, two Israeli projectiles hit the same hospital that was struck on Tuesday night, damaging the fourth floor, which housed a diagnostic center and the ultrasound and mammography units, the hospital administration said. However, the Israeli military denied that it had struck that area on Saturday.

Sameh said he and his family fled their home in Gaza City fearing that it could be in danger from Israeli rockets, and went to stay with an aunt. But then they grew concerned that her home was under threat as well, so they came to the hospital.

The auteur director is an appealing idea, as it romanticizes the ‘great artist’ by equating them spiritually with their work. Despite its flaws, it can be a helpful way of looking at the impact a director has not only on their own films, but on the movement with which they’re associated. After all, it’s nearly impossible to think about the French New Wave without Godard, or the American New Wave without Scorsese. Auteur directors come from across the globe and across time, but there is one critical disparity in the mechanics of authorship, and that is its exclusivity. The apparatus of authorship is one which acts against a sense of collectivity—you cannot feel special if you are just one of many artists operating within the same framework.

Ironically, it is the directors who have become most synonymous with their own personal ‘brand’—like Anderson or Tarantino—who are most obviously borrowing from other films. Successful collagists nearly supersede their original influences.

When you’re young, everything feels like it’s happening for the first time, and this is presented as the main reason to be invested. In a culture that is so obsessed with nostalgia bait, I somehow find it hard to believe that we’ve yet to find a way to market curation. We are in a golden era of collage, but we tend toward the ahistorical in a way that feels distinctly linked to the myth of American exceptionalism. There is no shame in carving out a spot within a larger tradition; the alternative seems to be incredibly lonely.

RIOT’s musical prowess is mostly self-taught. At 10, RIOT (born Ephrem Lopez Jr.) learned everything there was to know about loops and arrangements; at 15, he got his first DAW (digital audio workstation) and mastered Reason Studios, a music production software that remains his go-to.

“It's funny because Hype was just trying to call me a lyricist. I wouldn't consider myself a lyricist. Obviously, lyrics go into music and I do think about them and I do be having bars in my music but they're just super simple,” she says. “I want them to be digestible, I don't want them to fly over people's heads and they never catch it. I want people to hear it right away and be like, ‘OK, that was cute.’ But it's also fun at the same time.”

Ice is keenly aware of the comments made about her, but she isn’t interested in thoughts from nameless, faceless figures. In fact, she’s figuring out what internal rest looks like. Right now? It means she’s seven days into creating a workout and reading routine (her trainer just gave her James Clear’s bestseller Atomic Habits), taking frequent social media breaks and keeping her phone perpetually on DND (do not disturb), even putting me on to iPhone’s sleep mode. “It’s like super DND,” she giggles. “Very, very calming.”

So, aside from the people in her corner, whose opinion does she care about? “The critics,” she admits. “Because they actually study music and care about it. So I feel like I’d rather hear their opinion. ​​I'm more interested in that because at least it’ll be paragraphs explaining why they feel that way and I'll be able to understand the person better versus just one little hateful ass comment from a private page. At least there's an author and a face attached.”

Ice is leading a new class of women, including the likes of Kenzo B and Maiya the Don, who are changing what the drill scene looks and sounds like in New York, and appealing to an audience beyond its borders

The shift is happening in tandem with Latin music’s continual crawl further into the mainstream as pop’s leader in revenue and pace of growth. However, Ice has helped recenter hip-hop in mainstream culture and pop charts. Her take on the genre and unexpected rise might have been the reason why so many people had something to say about her landing the final slot on a Complex list ranking the best 50 New York rappers of all time.

Your best thinking is when you are fully engaged in the stuff in front of you, connecting it to other stuff—and finding your unique perspective amongst it all.

Ideally the cats are fed 5-6 small meals each day. The aim is for them to have a positive association with each other on re-introduction. This essentially means that ‘good’ things such as play or feeding will only happen in the presence of the other cat.

“The trailer of Dune is a good, good trailer of one industrial movie,” he says. “It’s good, but is similar to other pictures. Nothing, nothing which can open your mind. But it’s a lot of fun….this trailer shows me it is a good industrial picture, but it’s not art. It’s some kind of art. It’s industrial art. It’s possible, there are very marvelous industrial art pictures.”

I will quibble with “There is no simple formula”. It’s the execution that is difficult and complex. But at a high level the formula Apple has applied to make the iPhone (and iPad) the unprecedented success that they are is remarkably simple.

keep iterating, tirelessly and continuously, to improve that product year after year. Focus on aspects that cannot be copied or imitated. In the iPhone’s case, those are things such as custom chips, superior hardware components and manufacturing techniques, software frameworks decades in the making, a culture that prioritizes great design, and an ever-expanding ecosystem that keeps customers in the flock by making them happy.

Jonah provides basic instruction in mindfulness techniques, like focusing on the breath or sensations in the body, to learn to make space for difficult emotions and harsh, self-critical thought patterns nonjudgmentally.

When viewed with curiosity, the intensity of the emotions and thoughts is reduced, and clients gain more space to respond with wisdom and compassion. By observing these inner experiences without running away from them, mindfulness-based therapy helps clients increase insight into the patterns and underlying causes of mental health symptoms like anxiety, depression, or compulsive behavior.

While Andrew entered an internship at the office of Senator Sheldon Whitehouse of Rhode Island with the intention of attending law school, he came away from the experience feeling the political world was not suited for him. During his time at Student Agencies, Andrew was able to apply the lessons learned as a PAM major outside of the typical setting— an experience that ultimately deterred him from transferring out of his major. Outside of Student Agencies, Andrew was involved in a broad range of extracurricular activities at Cornell.

The term “mixed reality” emerged as a way to describe a class of related visual technologies. One of them, virtual reality, seals off users from much of the real world to immerse them in a digital experience. The other, augmented reality, makes digital items appear to inhabit the physical world.

This works well for difficult clients, coworkers, and any scenario when you're concerned you might get thrown under the bus or left cleaning up someone else's mess. In a junior position, these questions can also coax more senior designers to notice the issues that you see.