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Social isolation stress (SIS) as a type of chronic stress could induce depressive- and anxiety-like behaviors. Our study evaluates the role of opioid system on negative behavioral impacts of SIS in male NMRI mice. We investigated effects of morphine, a nonselective opioid receptor (OR) agonist, nalt …

Quality of life is an important consideration in the management of patients with Crohn's disease. Previous studies suggest that Crohn's disease patients using opioids may have decreased quality of life and increased risk of mortality. Our aim was to ...

Medical therapy and/or endoscopic balloon dilation with intralesional therapies are options for treatment of small bowel fibrostenotic Crohn’s disease (CD). To perform a systematic review summarizing evidence for efficacy of systemic and endoscopic ...

Download scientific diagram | Effect of methadone on amount of TNF-α in IBD rats. Methadone (5 and 10 mg/kg, s.c.) and (50 and 300 ng/rat, i.c.v.) administrations, (n = 6–8). ***P  0.001 significantly different from sham group. ##P  0.01 and ###P  0.001 significantly different from control group from publication: Involvement of central opioid receptors in protective effects of methadone on experimental colitis in rats | Purpose There are several lines of evidence on the protective roles of opioids in gastrointestinal inflammatory conditions. This study aims to distinguish the central and peripheral roles of methadone, a non-selective opioid receptor agonist, in an acute model of ulcerative... | Methadone, opioid receptors and Narcotic Antagonists | ResearchGate, the professional network for scientists.

activated fibroblasts for treating fibrosis in crohn's disease

Intestinal fibrosis is one of the most threatening complications of Crohn’s disease. It occurs in more than a third of patients with this condition, is associated with increased morbidity and mortality, and surgery often represents the only ...

Fibro-stenosing Crohn’s disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. From a pathobiology perspective, the conventional view that intestinal fibro-stenosis ...

In this study, [1] Ou and colleagues elucidate the mechanism regulating fibroblast activation in Crohn's Disease (CD) via YAP/TAZ. Blocking of YAP/TAZ-related mechanisms reduced fibroblast activation in a mouse model of Crohn's Disease. The study by Ou et al. identifies YAP/TAZ inhibitors as potential therapeutic targets to treat CD by reducing fibroblast activation.

Strongyloides colitis is a gastrointestinal manifestation of the parasitic infection, Strongyloides stercoralis, which may be misdiagnosed and treated as ulcera...

Stresses of moving house. Kent property news. Sussex property news. Budgeting for a new home. Legal & General. Hidden costs of moving house. Financial planning.

A survey into the nuances of stress reveals the frequency and causes of stress that many people with rosacea report as problematic.

Although perceived stress (PS) has been associated with symptomatic flares in inflammatory bowel disease, clinical and physiological measures associated with perceived stress and flare are not known. The aim of this study was to identify physiological factors associated with perceived stress in ulcerative colitis (UC) subjects, and their relationship with flare.

(1) Background: The aim of this study was to explore the role of perceived stress and the health locus of control in Crohn’s disease and their influence upon the development of flare-ups of this disease. (2) Methods: Stress and the external locus of ...

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease characterized by chronic and relapsing manifestations. It is noteworthy that the prevalence of IBD is gradually increasing in both children and adults. Currently, the ...

Many women say doctors ignore IUD pain and have posted videos documenting their distress during the procedure

Circadian rhythm disorders are when your body’s natural “clock” doesn’t work right. Learn about symptoms and what you can do.

Symptoms of Non-24 Hour Sleep-Wake Disorder include excessive daytime sleepiness and insomnia. Learn when to talk to your doctor about your symptoms.

Small Intestinal Bacterial Overgrowth https://humanmicrobiome.info/sibo/Human Microbiome wiki and forum – high-quality, evidence-based, trustworthy info & di...

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