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Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
The specific and significant COVID-19 risk of ADE should have been and should be prominently and independently disclosed to research subjects currently in vaccine trials, as well as those being recruited for the trials and future patients after vaccine approval, in order to meet the medical ethics s …
·pubmed.ncbi.nlm.nih.gov·
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
C19 VAX REACTIONS
C19 VAX REACTIONS
We are a large and ever growing group of Americans who were previously healthy and have been seriously injured by the COVID vaccines.
·c19vaxreactions.com·
C19 VAX REACTIONS
Cumulative Analysis of Early On Pfizer Vaccine Data - released by the FDA 11-17
Cumulative Analysis of Early On Pfizer Vaccine Data - released by the FDA 11-17
Review of the first batch of documents released by the FDA including the full scope of reported adverse events from Pfizer. Data collected was from the first 2.5 months of the public roll-out. The document was submitted to the FDA March 2021. Direct link to the FDA released document can be found in the report above. Full Document Released by the FDA can be found here:
·react19.org·
Cumulative Analysis of Early On Pfizer Vaccine Data - released by the FDA 11-17
Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study
Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study
Background: Ivermectin is a drug that has been shown to be active against coronavirus disease 19 (COVID-19) in previous studies. Healthcare personnel are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Therefore, ...
·ncbi.nlm.nih.gov·
Ivermectin as a SARS-CoV-2 Pre-Exposure Prophylaxis Method in Healthcare Workers: A Propensity Score-Matched Retrospective Cohort Study
Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease
Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease
Codon optimization describes the process used to increase protein production by use of alternative but synonymous codon changes. In SARS-CoV-2 mRNA vaccines codon optimizations can result in differential secondary conformations that inevitably affect a protein’s function with significant consequences to the cell. Importantly, when codon optimization increases the GC content of synthetic mRNAs, there can be an inevitable enrichment of G-quartets which potentially form G-quadruplex structures. The emerging G-quadruplexes are favorable binding sites of RNA binding proteins like helicases that inevitably affect epigenetic reprogramming of the cell by altering transcription, translation and replication. In this study, we performed a RNAfold analysis to investigate alterations in secondary structures of mRNAs in SARS-CoV-2 vaccines due to codon optimization. We show a significant increase in the GC content of mRNAs in vaccines as compared to native SARS-CoV-2 RNA sequences encoding the spike protein. As the GC enrichment leads to more G-quadruplex structure formations, these may contribute to potential pathological processes initiated by SARS-CoV-2 molecular vaccination.
·osf.io·
Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease
Why are we vaccinating children against COVID-19?
Why are we vaccinating children against COVID-19?
This article examines issues related to COVID-19 inoculations for children. The bulk of the official COVID-19-attributed deaths per capita occur in th…
·sciencedirect.com·
Why are we vaccinating children against COVID-19?
The epidemiological relevance of the COVID-19-vaccinated population is increasing
The epidemiological relevance of the COVID-19-vaccinated population is increasing
High COVID-19 vaccination rates were expected to reduce transmission of SARS-CoV-2 in populations by reducing the number of possible sources for transmission and thereby to reduce the burden of COVID-19 disease. Recent data, however, indicate that the epidemiological relevance of COVID-19 vaccinated individuals is increasing. In the UK it was described that secondary attack rates among household contacts exposed to fully vaccinated index cases was similar to household contacts exposed to unvaccinated index cases (25% for vaccinated vs 23% for unvaccinated).
·thelancet.com·
The epidemiological relevance of the COVID-19-vaccinated population is increasing
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
Vaccination reduces the risk of delta variant infection and accelerates viral clearance. Nonetheless, fully vaccinated individuals with breakthrough infections have peak viral load similar to unvaccinated cases and can efficiently transmit infection in household settings, including to fully vaccinated contacts. Host–virus interactions early in infection may shape the entire viral trajectory.
·thelancet.com·
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
COVID-19: stigmatising the unvaccinated is not justified
COVID-19: stigmatising the unvaccinated is not justified
In the USA and Germany, high-level officials have used the term pandemic of the unvaccinated, suggesting that people who have been vaccinated are not relevant in the epidemiology of COVID-19. Officials’ use of this phrase might have encouraged one scientist to claim that “the unvaccinated threaten the vaccinated for COVID-19”.1 But this view is far too simple.
·thelancet.com·
COVID-19: stigmatising the unvaccinated is not justified
COVID-19 Vaccines
COVID-19 Vaccines
All about COVID-19 vaccines including how to get vaccinations, searching for vaccination sites and vaccine type in Japan. Vaccinations are free of charge to anyone eligible.
·mhlw.go.jp·
COVID-19 Vaccines
Senior NIH expert pushes back on growing vaccine mandates
Senior NIH expert pushes back on growing vaccine mandates
Matthew Memoli favors vaccinations in vulnerable populations but argues population level vaccination could hinder the development of a natural, robust immunity gained through infection.
·thehill.com·
Senior NIH expert pushes back on growing vaccine mandates
Will covid-19 vaccines save lives? Current trials aren’t designed to tell us
Will covid-19 vaccines save lives? Current trials aren’t designed to tell us
The world has bet the farm on vaccines as the solution to the pandemic, but the trials are not focused on answering the questions many might assume they are. Peter Doshi reports As phase III trials of covid-19 vaccines reach their target enrolments, officials have been trying to project calm. The US coronavirus czar Anthony Fauci and the Food and Drug Administration leadership have offered public assurances that established procedures will be followed.1234 Only a “safe and effective” vaccine will be approved, they say, and nine vaccine manufacturers issued a rare joint statement pledging not to prematurely seek regulatory review.5 But what will it mean exactly when a vaccine is declared “effective”? To the public this seems fairly obvious. “The primary goal of a covid-19 vaccine is to keep people from getting very sick and dying,” a National Public Radio broadcast said bluntly.6 Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston, said, “Ideally, you want an antiviral vaccine to do two things . . . first, reduce the likelihood you will get severely ill and go to the hospital, and two, prevent infection and therefore interrupt disease transmission.”7 Yet the current phase III trials are not actually set up to prove either (table 1). None of the trials currently under way are designed to detect a reduction in any serious outcome such as hospital admissions, use of intensive care, or deaths. Nor are the vaccines being studied to determine whether they can interrupt transmission of the virus. View this table: Table 1 Characteristics of ongoing phase III covid-19 vaccine trials In a September interview Medscape editor in chief Eric Topol pondered what counts as a recorded “event” in the vaccine trials. “We’re not talking about just a PCR [polymerase …
·bmj.com·
Will covid-19 vaccines save lives? Current trials aren’t designed to tell us
Bill Gates admits COVID-19 vaccines don't stop viral transmission
Bill Gates admits COVID-19 vaccines don't stop viral transmission
Despite being one of the largest proponents of presently-available COVID-19 vaccines, Gates admits to the failure of the vaccine industry that he has worked tirelessly to prop up.
·rebelnews.com·
Bill Gates admits COVID-19 vaccines don't stop viral transmission