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Cleavage of the complement C3 protein is essential for complement activation. Saline extracts of human atherosclerotic lesions were examined by various techniques for the presence of C3 cleavage fragments. Crossed intermediate gel immunoelectrophoresis revealed that native C3 was the predominate C3 protein in extracts and that the C3dg fragment was also detected. SDS-PAGE/ Western blot analyses of lesion extracts employing monoclonal antibodies directed at C3c and C3dg fragment determinants demonstrated molecular weight bands corresponding to the known molecular weights of all the physiologic C3 cleavage fragments, except Cab which is known to have a short half-life.

Recombinant soluble complement inhibitors hold promise for the treatment of inflammatory disease and disease states associated with transplantation. T…

Recombinant soluble complement inhibitors hold promise for the treatment of inflammatory disease and disease states associated with transplantation. T…

In this issue of Blood, Yu et al have demonstrated that acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins activate complement by engaging the

In this issue of Blood, Yu et al have demonstrated that acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins activate complement by engaging the

Abstract. Complement alternative pathway plays an important, but not clearly understood, role in neutrophil-mediated diseases. We here show that neutrophils the

Abstract. Complement alternative pathway plays an important, but not clearly understood, role in neutrophil-mediated diseases. We here show that neutrophils the

Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate im...

The interactions of properdin with both surface-bound and fluid-phase C3 (the third component of complement) and its activation products have been investigated by using a purified preparation of the ‘native’ form. At physiological ionic strength, a weak interaction with cell-bound C3b (the larger activation fragment of C3) could be demonstrated....

PubMedのタイトルとアブストラクトに出現する略語とその展開形を検索します。

PubMedのタイトルとアブストラクトに出現する略語とその展開形を検索します。

Eye - The complement system and age-related macular degeneration

Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is ...

Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is ...

Characterization of cell-bound complement activation products on SLE PBMCs using mass cytometry (CyTOF®️)https://t.co/H3VgE5KvcJ https://t.co/HJOF5T20Am— Tal Varsano (@varsanot) April 19, 2019

Investigations into the mechanism of alternative pathway-dependent lysis of C4b-coated cells are reported. Test cells (EAC1q4b) were formed by reactio…

It has long been understood that the control and surveillance of tumors within the body involves an intricate dance between the adaptive and innate immune sy...

It has long been understood that the control and surveillance of tumors within the body involves an intricate dance between the adaptive and innate immune sy...

Although the complement system is thought to be mainly involved in innate immunity and in the humoral arm of adaptive responses, evidence implicating that complement impacts T cell responses are accumulating recently. The role of the various activation products of the major complement component C3 w …

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