Public health surveillance is the ongoing systematic collection, analysis, and interpretation of data, closely integrated with the timely dissemination of these data to those responsible for preventing and controlling disease and injury (Thacker and Berkelman 1988). Public health surveillance is a tool to estimate the health status and behavior of the populations served by ministries of health, ministries of finance, and donors. Because surveillance can directly measure what is going on in the population, it is useful both for measuring the need for interventions and for directly measuring the effects of interventions. The purpose of surveillance is to empower decision makers to lead and manage more effectively by providing timely, useful evidence.

Cluster Computing - Genome comparison poses important computational challenges, especially in CPU-time, memory allocation and I/O operations. Although there already exist parallel approaches of...

We present a two-level parallel strategy focused in the enhancement of GECKO software for multiple and pairwise genome comparisons. GECKO was developed to break the computational barriers on search space and memory demands faced by equivalent software. However,...

There has been a great evolution in the development of coronary stents in order to avoid both restenosis and thrombosis. Improvements have led to improvements in the design and conformation

Methods, apparatus and systems for detecting and monitoring vital signs and other periodic motions of an object are disclosed. In one example, a system for monitoring object motion in a venue is disclosed. The system comprises a transmitter, a receiver, and a vital sign estimator. The transmitter is located at a first position in the venue and configured for transmitting a wireless signal through a wireless multipath channel impacted by a pseudo-periodic motion of an object in the venue. The receiver is located at a second position in the venue and configured for: receiving the wireless signal through the wireless multipath channel impacted by the pseudo-periodic motion of the object in the venue, and obtaining at least one time series of channel information (TSCI) of the wireless multipath channel based on the wireless signal. The vital sign estimator is configured for: determining that at least one portion of the at least one TSCI in a current sliding time window is associated with the pseudo-periodic motion of the object in the venue, and computing a current characteristics related to the pseudo-periodic motion of the object in the current sliding time window based on at least one of: the at least one portion of the at least one TSCI in the current sliding time window, at least one portion of the at least one TSCI in a past sliding time window, and a past characteristics related to the pseudo-periodic motion of the object in the past sliding time window.

Methods, apparatus and systems for wireless sensing are described. In one embodiment, a described presentation system comprises: a presentation device with a user-interface; a processor communicatively coupled to the presentation device; a memory communicatively coupled to the processor; and a set of instructions stored in the memory. The set of instructions, when executed by the processor, causes the processor to perform: determining a plurality of time series of analytics (TSA) associated with a lifelog of a living object, determining a common time axis for the plurality of TSA, and generating a presentation that presents the plurality of TSA synchronously and jointly in a hybrid manner based on the common time axis. The presentation is presented on the user-interface of the presentation device.

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레포트, 리포트, 기말레포트, 기말리포트, 논문, 학술논문, 졸업논문, 레포트표지, 리포트표지, 이력서, 자기소개서, 감상문, 독후감, 방통대자료, 사업계획서 등의 지식 자료를 회원 간에 자유롭게 거래할 수 있습니다.

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Background A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that is critical for the development of autoimmunity. However, the role of CD11c+ B cells in the development of lupus is unclear. Chronic graft-versus-host disease (cGVHD) is a lupus-like syndrome with high autoantibody production. The purpose of this study was to explore the role of CD11c+ B cells in the pathogenesis of lupus in cGVHD mice. Methods cGVHD was induced by an intraperitoneal injection of 5 × 107 Bm12 splenocytes into B6 mice. Flow cytometry was used to analyze mice splenocytes and human samples. Magnetic beads were used to isolate mice B cells. Gene expression was determined by real-time quantitative polymerase chain reaction (RT-qPCR). Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies in serum and supernatants. Results The percentage and absolute number of CD11c+ B cells was increased in cGVHD-induced lupus, with elevated levels of antichromatin immunoglobulin (Ig)G and IgG2a in sera. CD11c+ plasma cells from cGVHD mice produced large amounts of antichromatin IgG2a upon stimulation. Depletion of CD11c+ B cells reduced antichromatin IgG and IgG2a production. T-bet was upregulated in CD11c+ B cells. Knockout of T-bet in B cells alleviated cGVHD-induced lupus. Importantly, the percentage of T-bet+CD11c+ B cells increased in lupus patients and positively correlated with serum antichromatin levels. Conclusion T-bet+CD11c+ B cells promoted high antichromatin IgG production in the lupus-like disease model cGVHD. In lupus patients, the percentage of T-bet+CD11c+ B cells was elevated and positively correlated with antichromatin antibodies. The findings provide potential therapeutic insight into lupus disease treatment.