Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives. - PubMed - NCBI
In an attempt to find novel azole antifungal agents with improved activity and broader spectrum, computer modeling was used to design a series of new azoles with piperidin-4-one O-substituted oxime side chains. Molecular docking studies revealed that they formed hydrophobic and hydrogen-bonding inte …