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Antibody-drug conjugates (ADCs), which combine the specificity, favorable pharmacokinetics, and biodistribution of a monoclonal antibody (mAb) with the cytotoxic potency of a drug, are promising new therapies for cancer. Along with the development of monoclonal antibodies (mAbs) and cytotoxic drugs, …

The company’s technology is designed to attach any off-the-shelf antibody with any payload without the need for modification.

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market, 2019-2030 Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market, 2019-2030 - Market research report and industry analysis - 13084685

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Antibody-drug conjugates allow for targeted delivery of chemotherapy to tumours, therefore reducing off-target effects for patients.

The mammalian circadian clock is driven by a transcriptional–translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of the clock depends on the complex formation and periodic turnover of the Period and Cryptochrome ...

Circadian rhythms are oscillations in the biochemical, physiological, and behavioral functions of organisms that occur with a periodicity of approximately 24 h. They are generated by a molecular clock that is synchronized with the solar day by environmental photic input. The cryptochromes are the ma …

The cry gene family, produced during the late exponential phase of growth in Bacillus thuringiensis, is a large, still-growing family of homologous genes, in which each gene encodes a protein with strong specific activity against only one or a few insect ...

The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including ...

Nuclear receptors are activated by lipid-soluble signals (e.g., steroid hormones) that cross the plasma membrane. Once activated, most function as transcription factors to control gene expression for numerous biological processes.

The strong magnetic field properties of magnets have led to their use in many modern technologies, as well as in the fields of medicine and dentistry. Neodymium magnets are a powerful type of magnet that has been the subject of recent research. This review ...

Check out the latest information on Irish trainers and keep up to date on their season details, most recent runners and notable Irish wins.

In this column, author John J. Walsh revisits a past column explaining questions that can help in choosing the best fluid-bed dryer for an application.

At SFI we believe in the ability of science, technology, engineering & maths to effect positive change in the world and drive a sustainable international economy. https://www.sfi.ie/research-news/news/icrag-kobold-metals/