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[En Español] There are few things I find more satisfying than a good acronym, and DREADD  or Designer Receptor Exclusively Activated by a Designer Drug has got to be my favorite.  The name is just …

The designer receptors exclusively activated by designer drugs (DREADD) system can be used to suppress nociceptors, resulting in analgesia to heat, reports a new mouse study. But thanks to a set of careful control experiments, researchers led by Brian Davis and Michael Gold, University of Pittsburgh, US, also find an important caveat: DREADD expression alters endogenous channel activity and signaling pathways in sensory neurons independent of the ligand used to activate the receptor.

"spatiality" published on by null.

The new tool is some of the first research to come out of the BRAIN Initiative.

Spatial Theory BIBLIOGRAPHY Source for information on Spatial Theory: International Encyclopedia of the Social Sciences dictionary.

The human person is a relational being. One initial aspect of this is the human-to-nature relationship. Humans use nature, as other animals do, to obtain food, protect themselves and acquire a...

Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.

This is the second week of my new thematic mini-series called Literary Time Consciousness. In this series, I’m looking at various ways that literature can challenge or disrupt the way we thin…

Brett Story explores the roots of solitary confinement in North American prisons, and the profound and often devastating impact it has on people who are severed from social contact.

Pfizer CEO Albert Bourla told Fox News the company has a system in place to turn around a variant-specific jab within 95 days in the likelihood a vaccine-resistant COVID strain emerges, but experts warn that strategy will backfire.

On one reading, postcolonial studies seem to be riveted more firmly on temporal as opposed to spatial questions. This may be traced partly to the effect of the temporalizing "post-" in the term postcolonialism, which has allowed an insistence on various dates as inaugurating the epochal postcolonial relation.

Abstract This article focuses on Egypt’s moment of decolonisation in order to explore some of the productive tensions between Marxism, Frantz Fanon’s work, and postcolonial contexts. Through a reading of Egypt’s attempts at independent industrialisation and decolonising ‘the international’, the article uses Frantz Fanon’s invitation to ‘stretch Marxism’ as a way of understanding the particularities of capitalism in the colonial and postcolonial world. It is posited that events such as decolonisation across the postcolonial world have been central to the evolution of global capitalism, and should be centred within Marxist analyses of global politics. It is further argued that these moments can shed light on the contradictions of nationalism, sovereignty and independence, and the ways in which anticolonialism in places like Egypt ultimately reproduced, rather than challenged, colonial capitalism.

Necessarily, we must dismiss those tendencies that encourage the consoling play of recognitions. Michel Foucault, ‘Nietzsche, Genealogy, History’ When was ‘the post-colonial’? What should be…

This chapter contains sections titled: Introduction Communication Policy as Development: The View from the South Colonial Power and the Rule of Law The Nostalgia for NWICO in Retrospect Neo...

Thinking between the Posts: Postcolonialism, Postsocialism, and Ethnography after the Cold War - Volume 51 Issue 1

The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed. Recent advances in understanding microbial opsins have been driven by molecular engineering for optogenetics and by comparative genomics. Here we provide a Primer on these light-activated ion channels and pumps, describe a group of opsins bridging prior categories, and explore the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines.