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MONTEQLONAL ANTIBUDDY
Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development - PubMed
This review, which summarizes our findings concerning the long-term effects of pre-, peri- and postnatal factors affecting development, nociception and sensorimotor functions, focuses on three areas: 1) perinatal factors influencing nociception in adult rats were examined in rats with hippocampal le …
Antipyretic effectiveness of intravenous ketorolac tromethamine - PubMed
We assessed the antipyretic effectiveness of intravenously administered ketorolac tromethamine in the febrile adult. A double-blind placebo controlled trial enrolling a convenience sample of febrile (T > 38.0 degrees C, oral) patients (18-65 years old) randomized to receive either 0.5 mg/kg (max …
Antipyretic - Google Search
prostaglandin-induced increase in temperature - Google Search
Neural Mechanisms of Inflammation-Induced Fever - Anders Blomqvist, David Engblom, 2018
Fever is a common symptom of infectious and inflammatory disease. It is well-established that prostaglandin E2 is the final mediator of fever, which by binding ...
VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse
The monoaminergic neuron, in particular the dopaminergic neuron, is central to mediating the hedonic and addictive properties of drugs of abuse. The effects of amphetamine (AMPH) and cocaine (COC), for example, depend on the ability to increase dopamine ...
Is a fever harmful or beneficial? When should a fever be treated? | American Academy of Pediatrics
Evidence supports a beneficial effect of an elevated temperature as well as a possible adverse effect of fever on the clinical outcome of an infection.
Antipyretics: mechanisms of action and clinical use in fever suppression - The American Journal of Medicine
Antipyretic Therapy: Physiologic Rationale, Diagnostic Implications, and Clinical Consequences | Pain Medicine | JAMA Internal Medicine | JAMA Network
Various treatments have been used to suppress fever since antiquity. Surprisingly, few studies have been performed to ascertain the physiologic consequences of antipyresis and validate the rationale behind such therapy. More importantly, it has not been established conclusively that the benefits of...
Control of Fever in Septic Shock: Should We Care or Intervene? | American Journal of Respiratory and Critical Care Medicine
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception | Journal of Neuroinflammation | Full Text
Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation. Peripheral tissues undergo many forms of diseases that are frequently accompanied by inflammation. The somatosensory nerves innervating the inflamed areas experience heightened excitability and generate and transmit pain signals. Extensive studies have been carried out to elucidate how prostaglandins play their roles for such signaling at the cellular and molecular levels. Here, we briefly summarize the roles of arachidonic acid-derived prostaglandins, focusing on four prostaglandins and one thromboxane, particularly in terms of their actions on afferent nociceptors. We discuss the biosynthesis of the prostaglandins, their specific action sites, the pathological alteration of the expression levels of related proteins, the neuronal outcomes of receptor stimulation, their correlation with behavioral nociception, and the pharmacological efficacy of their regulators. This overview will help to a better understanding of the pathological roles that prostaglandins play in the somatosensory system and to a finding of critical molecular contributors to normalizing pain.
epoxygenase - Google Search
Epoxygenase Pathways of Arachidonic Acid Metabolism* - Journal of Biological Chemistry
Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases | Advances in Nutrition | Oxford Academic
ABSTRACT. Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obes
Molecular Characterization of an Arachidonic Acid Epoxygenase in Rat Brain Astrocytes | Stroke
Background and Purpose Brain parenchymal tissue metabolizes arachidonic acid (AA) via the cytochrome P450 (P450) epoxygenase to epoxyeicosatrienoic acids (EETs). EETs dilate cerebral arterioles and e
GFAP Antibody (13-0300)
Invitrogen Anti-GFAP Monoclonal (2.2B10), Catalog # 13-0300. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (IHC), Flow Cytometry (Flow), Immunoprecipitation (IP) and ELISA (ELISA) applications. This antibody reacts with Bovine, Human, Mouse, Rat samples. Supplied as 100 µg purified antibody (0.5 mg/mL).
Cross-fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods - PubMed
There are studies showing that drug abuse during pregnancy may have a long-term effect on progeny of drug-abusing mothers. Our previous work demonstrated that prenatal and/or postnatal methamphetamine injections impair maternal behavior. The purpose of the present study was to assess the effect of p …
Perinatal effect of methamphetamine on nociception in adult Wistar rats - PubMed
Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whos …
Click on image to zoom
Prenatal and perinatal factors influencing nociception, addiction and behavior during ontogenetic development - PubMed
This review, which summarizes our findings concerning the long-term effects of pre-, peri- and postnatal factors affecting development, nociception and sensorimotor functions, focuses on three areas: 1) perinatal factors influencing nociception in adult rats were examined in rats with hippocampal le …
Antipyretic effectiveness of intravenous ketorolac tromethamine - PubMed
We assessed the antipyretic effectiveness of intravenously administered ketorolac tromethamine in the febrile adult. A double-blind placebo controlled trial enrolling a convenience sample of febrile (T > 38.0 degrees C, oral) patients (18-65 years old) randomized to receive either 0.5 mg/kg (max …
GFAP Antibody (13-0300)
Invitrogen Anti-GFAP Monoclonal (2.2B10), Catalog # 13-0300. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (IHC), Flow Cytometry (Flow), Immunoprecipitation (IP) and ELISA (ELISA) applications. This antibody reacts with Bovine, Human, Mouse, Rat samples. Supplied as 100 µg purified antibody (0.5 mg/mL).
Cross-fostering effect on postnatal development of rat pups exposed to methamphetamine during gestation and preweaning periods - PubMed
There are studies showing that drug abuse during pregnancy may have a long-term effect on progeny of drug-abusing mothers. Our previous work demonstrated that prenatal and/or postnatal methamphetamine injections impair maternal behavior. The purpose of the present study was to assess the effect of p …
Perinatal effect of methamphetamine on nociception in adult Wistar rats - PubMed
Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whos …