The Icarus Project was an Unreal level designed by Daedra Christopher which can be found here: https://www.daedrachristopher.com/portfolio/the-icarus-project/. The original lighting was good, but I wanted to increase the dark, moody atmosphere. Daedra really wanted to push the hopeless, oppressive feeling in this space, so I gleaned inspiration from many movies including Blade Runner, Robocop, Event Horizon, and Total Recall. In order to achieve the strong emotions the designer wanted, I created an overall dark appearance to the atmosphere. I used spotlights and bloom to direct the player to points of interest, as if a guiding hand is reaching out from the darkness. The decals with emissive textures symbolize the oppressed people of Hong Kong station's hope and rebellion alike. The futuristic glowing neon kanji splashed across the grungy walls create visual breaks from tiling textures while adding saturated colour to draw the player further into the map.

Abstract This article focuses on Egypt’s moment of decolonisation in order to explore some of the productive tensions between Marxism, Frantz Fanon’s work, and postcolonial contexts. Through a reading of Egypt’s attempts at independent industrialisation and decolonising ‘the international’, the article uses Frantz Fanon’s invitation to ‘stretch Marxism’ as a way of understanding the particularities of capitalism in the colonial and postcolonial world. It is posited that events such as decolonisation across the postcolonial world have been central to the evolution of global capitalism, and should be centred within Marxist analyses of global politics. It is further argued that these moments can shed light on the contradictions of nationalism, sovereignty and independence, and the ways in which anticolonialism in places like Egypt ultimately reproduced, rather than challenged, colonial capitalism.

Thinking between the Posts: Postcolonialism, Postsocialism, and Ethnography after the Cold War - Volume 51 Issue 1

In the past decade, emerging synthetic biology technologies such as chemogenetics have dramatically transformed how pharmacologists and systems biologists deconstruct the involvement of G protein–coupled receptors (GPCRs) in a myriad of physiological and translational settings. Here we highlight a specific chemogenetic application that extends the utility of the concept of RASSLs (receptors activated solely by synthetic ligands): We have dubbed it DREADDs (designer receptors exclusively activated by designer drugs). As we show in this review, DREADDs are now used ubiquitously to modulate GPCR activity noninvasively in vivo. Results from these studies have directly implicated GPCR signaling in a large number of therapeutically relevant contexts. We also highlight recent applications of DREADD technology that have illuminated GPCR signaling processes that control pathways relevant to the treatment of eating disorders, obesity, and obesity-associated metabolic abnormalities. Additionally, we provide an overview of the potential utility of chemogenetic technologies for transformative therapeutics.

DREADDs (designer receptors exclusively activated by designer drugs) are a powerful and tremendous new technique for selectively manipulating a specific neuronal (or non-neuronal) subpopulation. Recent studies indicate, however, that ligands used for DREADDs, such as clozapine- N -oxide or its parent compound clozapine, are not as selective as expected, even at reasonable concentrations. Although the new generation of ligands specifically developed for DREADDs or alternative chemogenetic receptors may present some improvements, the absence of potential off-target effects remains to be fully demonstrated. Together, indications from the recent literature on DREADDs should warn current and future users about some weaknesses of this expanding technique in the field of integrative neuroscience and encourage them to take some specific precautions to avoid important pitfalls with DREADDs, which remain a promising and complementary approach to optogenetics with the relevant controls. Over the past decade, chemogenetic and optogenetic techniques have revolutionized integrative neuroscience by providing new tools to reversibly manipulate the activity of specific populations or neurotransmitter systems with greater selectivity (Sternson and Roth, 2014; Roth, 2016; Wiegert et al., 2017). Compared with optogenetics, which allow fast and phasic neuronal modulation with high temporal resolution, chemogenetics allow more extended modulation of systems, which is particularly useful for studies focusing on tonic phenomena (e.g., investigation of the implication of dopamine in motivational processes; Whissell et al., 2016). Among chemogenetic tools, designer receptors exclusively activated by designer drugs (DREADDs) are widely used and are referred to as a biological “lock-and-key” system for selective manipulation of cell activity through G-protein signaling pathways. First developed very elegantly by the Roth’s group (Armbruster et al., 2007), this G-protein-coupled receptor (GPCR) is a muscarinic receptor: the lock, which was mutated to respond only to clozapine- N -oxide (CNO), the …

Designer receptors help understand cellular signals and could treat epilepsy and Parkinson's disease, but need new tools, finds Andy Extance

Thevisualdrop crew doing an awesome job on Angelo Grubišić - Icarus Project

Teaser - A few days in the Dolomites testing a new prototype Icarus wingsuit. Full video coming soon. Eternal thanks to Squirrel for building our suits, Pressurized for load organising the helicopter.

Cheddar gets a look at Curiosity Stream's 'Icarus: Tracking Creatures from Space.'

By RR Jacobina, Published on 04/30/08

Building Mad Maps for Wellness in a Mad World

I'm very excited to announce that I have joined the awesome team at Gravity Industries in the development of jetsuit technology. We have been demonstrating the ability of other pilots to train the necessary strenghth and motor skills to fly a jetsuit based only on the raw power of jet engines and the ability of the human mind and body to harness them. This is just the beginning.. #takeongravity

The present study describes Psychosocial Care as a new paradigm currently operating within the Brazilian Psychiatric Reform, emphasising one of its key elements...

Meaning of manicomial in the Portuguese dictionary with examples of use. Synonyms for manicomial and translation of manicomial to 25 languages.

Sometimes it’s difficult for me to convey the feeling of flying a wingsuit in close proximity to terrain, but I think this new style of filming gives some great insight into the intensity and concentration. Diving at over 200km/h through the crack feels like travelling at light speed. #wingsuit #proximity #Switzerland #flight #BASEjump #extremesports. Follow us on Instagram: @icarusangelo Facebook: @icarusangelo

O Dicionário Priberam da Língua Portuguesa (DPLP) é um dicionário de português contemporâneo com cerca de 165 000 entradas lexicais, incluindo locuções e fraseologias.