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Hundreds of hormones and ligands stimulate cyclic AMP (cAMP) signaling in different tissues through the activation of G-protein-coupled receptors (GPCRs). Although the functions and individual effectors of cAMP signaling are well characterized in ...

Evolving research on Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) may someday lead to new therapies for treatment-resistant neuropsychiatric disorders.

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Donee’s Liability for Unpaid Gift Tax and Interest Capped by Value of the Gift:  The U.S. Court of Appeals for the Fifth Circuit held yesterday in United States v. Marshall  that a donee’s liability f...

We have translated a powerful genetic tool, designer receptors exclusively activated by designer drugs (DREADDs), from mammalian systems to Drosophila melanogaster to selectively, rapidly, reversibly, and dose-dependently control behaviors and physiological processes in the fly. DREADDs are muscarinic acetylcholine G protein-coupled receptors evolved for loss of affinity to acetylcholine and for the ability to be fully activated by an otherwise biologically inert chemical, clozapine-N-oxide. We demonstrate its ability to control a variety of behaviors and processes in larvae and adults, including heart rate, sensory processing, diurnal behavior, learning and memory, and courtship. The advantages of this particular technology include the dose-responsive control of behaviors, the lack of a need for specialized equipment, and the capacity to remotely control signaling in essentially all neuronal and nonneuronal fly tissues.

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Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.

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Pfizer CEO Albert Bourla told Fox News the company has a system in place to turn around a variant-specific jab within 95 days in the likelihood a vaccine-resistant COVID strain emerges, but experts warn that strategy will backfire.

This is the second week of my new thematic mini-series called Literary Time Consciousness. In this series, I’m looking at various ways that literature can challenge or disrupt the way we thin…

The human person is a relational being. One initial aspect of this is the human-to-nature relationship. Humans use nature, as other animals do, to obtain food, protect themselves and acquire a...

This was the third in a series of femminars provided by The Icarus Project and facilitated by Kai Cheng Thom and Elena Rose. This is an emotional safety planning webinar by-and-for trans women, trans femmes, and trans feminine people (assigned male at birth). In it, the facilitators talk about suicidality in our communities and selves, and share skills and strategies to navigate emotional distress, crisis intervention, and resilience. Please consider making a sliding scale contribution at bit.ly/supporticarus to support this work if you are able to give! ***Please note: watching this femminar may bring up strong feelings and triggers. So, before you begin, take a moment to think about and make plans for what you need to feel safe(r) and grounded during and after the femminar. Things to think about might include: Where is a quiet, comfortable place where you will have privacy, snacks and comfort? We hope to have the final femminar (by-and-for femmes of color) edited and uploaded by January 21st, along with links to the resource list, so check back for more information. We are working on securing funding to provide closed captioning and transcription of this video. Send an email to maryse[at]theicarusproject.net to be notified if and when this is made possible. Thank you!

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Power Management keeps being a very valuable asset for mobile applications. CPF (Common Power Format) is a common file format to describe the power structure of the design in the early design stages that makes it a very critical design step input of the VLSI design flow. It is possible to verify a design from low power point of view using lint tools and/or simulations without CPF, but not as effective as a CPF based simulation methodology.

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