The report from Trinity Partners details findings from qualitative research with 10 medical directors at US payer organizations, representing plans covering over 100 million commercial and Medicare enrollees in the United States.

Clinical trials can fail to detect rare adverse events (AEs). We assessed the ability of pharmacological target adverse-event (TAE) profiles to predict AEs on US Food and Drug Administration (FDA) drug labels at least 4 years after approval. TAE profiles were generated by aggregating AEs from the FD …

The report from Trinity Partners details findings from qualitative research with 10 medical directors at US payer organizations, representing plans covering over 100 million commercial and Medicare enrollees in the United States.

[vc_row][vc_column width=”7/12″][vc_empty_space][vc_single_image image=”686″ img_size=”full” alignment=”right” el_class=”pure-img”][/vc_column][vc_column width=”5/12″][vc_column_text] Ebeam Systems PCT offers innovative and reliable electron beam (ebeam) systems for a multitude of industrial applications.  Our systems feature our patented, integrated shield roll design and the latest digital technology in high voltage power supplies.  Don’t see a standard ebeam system that will work for your application?  […]

This article estimates potential future savings from biosimilars, summarizes the experience to date with the first marketed biosimilar, and discusses key policy issues surrounding biosimilars in the United States.

The purpose of this research was to analyze and compare the responses of three Process Analytical Technology (PAT) techniques applied simultaneously to monitor a pilot-scale fluidized bed granulation process. Real-time measurements using focused beam reflectance measurement (Lasentec FBRM) and near- …

This article estimates potential future savings from biosimilars, summarizes the experience to date with the first marketed biosimilar, and discusses key policy issues surrounding biosimilars in the United States.

As a nurse and supervisor of an acute surgical ward, I found the CPD article interesting because it identified ways to monitor staff performance continually. The approach to staff appraisal described was suitable for addressing poor performance and acknowledging good performance among nurses.

BACKGROUND AND PURPOSE: A previous study demonstrated the need to use delayed acquisition rather than first-pass data for accurate blood-brain barrier permeability surface product (BBBP) calculation from perfusion CT (PCT) according to the Patlak model, but the optimal duration of the delayed acquisition has not been established. Our goal was to determine the optimal duration of the delayed PCT acquisition to obtain accurate BBBP measurements while minimizing potential motion artifacts and radiation dose. MATERIALS AND METHODS: We retrospectively identified 23 consecutive patients with acute ischemic anterior circulation stroke who underwent a PCT study with delayed acquisition. The Patlak model was applied for the full delayed acquisition (90–240 seconds) and also for truncated analysis windows (90–210, 90–180, 90–150, 90–120 seconds). Linear regression of Patlak plots was performed separately for the full and truncated analysis windows, and the slope of these regression lines was used to indicate BBBP. The full and truncated analysis windows were compared in terms of the resulting BBBP values and the quality of the Patlak fitting. RESULTS: BBBP values in the infarct and penumbra were similar for the full 90- to 240-second acquisition (95% confidence intervals for the infarct and penumbra: 1.62–2.47 and 1.75–2.41 mL ×100 g−1 × min−1, respectively) and the 90- to 210-second analysis window (1.82–2.76 and 2.01–2.74 mL × 100 g−1 × min−1, respectively). BBBP values increased significantly with shorter acquisitions. The quality of the Patlak fit was excellent for the full 90- to 240-second and 90- to 210-second acquisitions, but it degraded with shorter acquisitions. CONCLUSIONS: The duration for the delayed PCT acquisition should be at least 210 seconds, because acquisitions shorter than 210 seconds lead to significantly overestimated BBBP values.

The aims of this pilot study were to: i) conduct a thorough behavioral and medical evaluation of cats presenting for chronic fabric ingestion; and ii) implement specific treatments for conditions identified and evaluate the outcome of treatment on fabric ingestion. Eight cats which ingested fabric a …

A framework of Human Error Probability (HEP) parameters, which is needed for Human Reliability Analysis (HRA) within a practice of Probabilistic Safety Assessment (PSA) of Nuclear Power Plant is first proposed. Then a laboratory experiment was conducted in order to construct a computer simulation mo …

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