Metallurgical and Materials Transactions A - An Al-5.8 at. pct Mg (5.2 wt pct Mg) alloy was deformed in torsion within the solute drag regime to various strains, up to the failure strain of 10.8....

Monamine oxidase inhibitor drugs (MAOIs) are an uncommonly prescribed class of antidepressant drugs. Learn more about MAOI side effects and adverse reactions.

Despite its abundant supply, tobacco stem has not been exploited as an energy source in large scale. This study investigates the combustion behaviours of tobacco stem in a thermogravimetric analyser (TGA) and a pilot-scale fluidized bed (FB). Combustion characteristics, including ignition and burnou …

For over 100 years a central assumption in the field of neuroscience has been that new neurons are not added to the adult mammalian brain. This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse. The acceptance of adult neur …

Metallurgical and Materials Transactions A - An Al-5.8 at. pct Mg (5.2 wt pct Mg) alloy was deformed in torsion within the solute drag regime to various strains, up to the failure strain of 10.8....

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.

Ridesco WG, featuring the active ingredients dinotefuran and alpha-cypermethrin, can be used to control ants, house flies, American cockroaches and spiders.

Haematopoietic stem cells give rise to progeny that progressively lose self-renewal capacity and become restricted to one lineage. The points at which haematopoietic stem cell-derived progenitors commit to each of the various lineages remain mostly unknown. We have identified a clonogenic common lym …

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk between these organs. This review discusses current evidence for the cellular and molecular mechanisms by which various neurological disease categories, including autoimmune, developmental, dementia-related, movement, neuromuscular, stroke, trauma, and psychological, impart changes in bone homeostasis and mass, as well as fracture risk. Likewise, how bone may affect neurological function is discussed. Gaining a better understanding of brain-bone interactions, particularly in patients with underlying neurological disorders, may lead to development of novel therapies and discovery of shared risk factors, as well as highlight the need for broad, whole-health clinical approaches toward treatment.

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk ...

The PCT simplifies and reduces the cost of obtaining international patent protection and facilitates public access to a wealth of technical information relating to inventions.

Neurological diseases, particularly in the context of aging, have serious impacts on quality of life and can negatively affect bone health. The brain-bone axis is critically important for skeletal metabolism, sensory innervation, and endocrine cross-talk ...

Aging is associated with a progressive loss of bone-muscle mass and strength. When the decline in mass and strength reaches critical thresholds associated with adverse health outcomes, they are operationally considered geriatric conditions and named, ...

The PCT simplifies and reduces the cost of obtaining international patent protection and facilitates public access to a wealth of technical information relating to inventions.

Aging is associated with a progressive loss of bone-muscle mass and strength. When the decline in mass and strength reaches critical thresholds associated with adverse health outcomes, they are operationally considered geriatric conditions and named, ...

It is demonstrated that amphetamine users suffer from a generalized reduction in bone mass, which was associated with attenuated maximal muscle strength and force development capacity in the lower extremities. SummaryThis study examined musculoskeletal health in amphetamine users, compared with healthy age-matched controls. We show that amphetamine users have reduced bone mass at several skeletal sites and attenuated maximal muscle strength and force development capacity in the lower extremities.IntroductionAmphetamine use may cause poor bone quality and elevated risk of osteoporosis. The purpose of this study was to investigate whether amphetamine users exhibit reduced regional and whole body bone mineral density (BMD), altered bone metabolism, and how muscle function may relate to the patient groups’ skeletal health.MethodsWe assessed hip, lumbar spine and whole body BMD, and trabecular bone score (TBS) by dual x-ray absorptiometry (DXA), and bone metabolism markers in serum and maximal strength and force development capacity in 36 amphetamine users (25 men, 30 ± 7 years; 11 women 35 ± 10 years) and in 37 healthy controls (23 men, 31 ± 9 years; 14 women, 35 ± 7 years).ResultsWhole body BMD was lower in amphetamine users (8 % in males and 7 % females, p

1375 Objectives: PET-CT has great potential in monitoring drugs pharmacokinetics and pharmacodynamics in anti-angiogenic therapy. We explore the feasibility of using dPET and pCT to assess tumor blood flow (TBF) in this context. Methods: Three patients with unresectable non small cell lung carcinoma (stage 3b) and colorectal carcinoma (stage 4) received 1 cycle of an anti-angiogenic drug therapy. Immediately before and 7-14 days after therapy, patients were injected with 50mCi of Rb-82 and imaged dynamically for 6 min using PET/CT. Ventricular input functions and TBF (ml/g/min) were computed using generalized factor analysis of dynamic sequences and 2-compartment kinetic modeling. pCT was also performed and TBF computed in contiguous slices (9.6mm tichk) centered on the lesion. Results: TBF measured with dPET and pCT followed the same trend: Pat1 had 26% reduction of TBF on dPET (10% reduction on pCT) and an unconfirmed partial response. In pat2, there was 15% reduction of TBF on dPET (38% on pCT) and the patient’s disease remained stable. In pat3, there was a TBF increase of 21% on PET (45% on pCT) and the patient did not respond to therapy. Our results show reasonable correlation between pCT and dPET perfusion estimates. Conclusions: dPET and pCT have an important potential role in early assessment of response to anti-angiogenic therapy. dPET and pCT derived tumor blood flows follow similar trends before and after therapy, with dPET having the advantage of estimating TBF within the entire tumor, rather than sampling a small region with pCT. Further studies are warranted. Research Support: NIH (RO1-[EB005876][1]), Bracco Diagnostics [1]: /lookup/external-ref?link_type=GEN&access_num=EB005876&atom=%2Fjnumed%2F49%2Fsupplement_1%2F324P.4.atom