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We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, ...

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A 25-kDa antioxidant enzyme that provides protection against oxidation systems capable of generating reactive oxygen and sulfur species has previously been identified. The nature of the oxidant eliminated by, and the physiological source of reducing equivalents for, this enzyme, however, were not kn …

Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials, which enable spatiotemporal orchestration of various immunological events for mounting a highly potent and long-lasting ant …

Newly made hybrid nanosensors measured thermal conductivity in cells to be about one-sixth of that in water.

Plants have to contend with biotic stress, such as disease, mechanical wounding, and herbivory, as well as abiotic stress, such as heat, cold, and salinity. An early warning system for these threats would prevent or reduce the damage suffered by plants. Such a warning system should allow the signal …

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms and essential for the stability of long-lived cells in mammals. Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem …

Nature Reviews Materials - The field of DNA nanotechnology takes the DNA molecule out of its biological context and uses its information to assemble structural motifs and connect these motifs...

In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS)-configured decahydroquinoxalines 5-8 was developed. Physicochemical and pharmacological properties were fine-tuned by structural modifications in the arylacetamide and amine …

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(2020). Current strategies to enhance the targeting of polydopamine-based platforms for cancer therapeutics. Journal of Drug Targeting: Vol. 28, No. 2, pp. 142-153.

Polydopamine (PDA) is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation. Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent fr

Synthesis of Polydopamine Nanoparticles for Drug Delivery Applications - Volume 24 Issue S1

Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in organisms as diverse as cyanobacteria and humans. All current models of the molecular circadian clockwork in eukaryotic cells are based on transcription-translation feedback loops. Non-transcriptional mechanisms in …

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Regenerative nanotechnology in oral and maxillofacial surgery Kaveh Shakib , Aaron Tan , Vukic Soskic and Alexander M. Seifalian British Journal of Oral and Maxillofacial Surgery, 2014-12-01, Volume 52, Issue 10, Pages 884-893, Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons Abstract Regenerative nanotechnology is at the forefront of medical research, and…

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System and method for securing a personal device that includes a device core and a peripheral device from unauthorized access or operation. The system comprises an isolated switch, included fully or partially within an envelope of the personal device. The isolated switch cannot be affected in its operation by either the device core or the peripheral device. The switch may be operated by an authorized user of the personal device either preemptively or in response to a detected threat. In some embodiments, the isolated switch includes an isolated controller which can send one or more signals to the peripheral device and/or part of peripheral device. In some embodiments, the isolated switch includes an isolated internal component and an isolated external component, both required to work together to trigger the isolated switch operation. In some embodiments, the isolated switch includes an isolated disconnector for connecting and disconnecting the device core from part of the peripheral device.

Abstract. In this study, the polydopamine (PDA) film was coated on polished 316Lss and then thermally treated at 150 °C (labeled as PDA-Th150), and the stabilit

Mitochondrial biogenesis is a complex process. It necessitates the participation of both the nuclear and the mitochondrial genomes. This process is highly regulated, and mitochondrial content within a cell varies according to energy demand. In the yeast Saccharomyces cerevisiae, the cAMP pathway is …