Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction

Metallurgical and Materials Transactions A - Ballistic impact experiments were conducted on 12.5 mm thick commercial purity titanium and Ti-6 pct Al-4 pct V alloy plates using steel...

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Procalcitonin concentrations are considered as a component of the inflammatory response and as an acute-phase marker, after shock or tissue injury (i.e. burn, trauma, surgery) or infections and sepsis. No data are so far available on the dynamics of procalcitonin ...

Background Early sepsis diagnosis is crucial for the correct management of burn patients, and it clearly influences outcomes. The systemic inflammatory response triggered by burns mimics sepsis presentation and complicates early sepsis diagnosis. Biomarkers were advocated to aid the diagnosis of early sepsis. Serum procalcitonin (PCT) exhibits fair accuracy and good correlation with sepsis severity, being used in diverse clinical settings. However, few studies have evaluated perioperative changes in PCT levels in burn patients. The present study evaluated PCT kinetics during the first days after burn injury and subsequent surgical interventions to assess PCT utility in distinguishing septic from non-septic inflammatory responses. Methods This study was a retrospective observational study of all burn patients admitted to the Coimbra Burns Unit (Portugal) between January 2011 and December 2014 who presented with a total burn surface area ≥ 15% and who underwent subsequent surgery. PCT kinetics were investigated a) during the first five days after burn injury and b) preoperatively during the five days after surgery in three subsets of patients, including those with no preoperative and no postoperative sepsis (NN), no preoperative but postoperative sepsis (NS), and preoperative and postoperative sepsis (SS). A total of 145 patients met the selection criteria and were included in the analysis. Results PCT levels in the first five days after burn injury were significantly higher in patients who developed at least one sepsis episode (n = 85) compared with patients who did not develop sepsis (n = 60). PCT values > 1.00 ng/mL were clearly associated with sepsis. Study participants (n = 145) underwent a total of 283 surgical interventions. Their distribution by preoperative/postoperative sepsis status was 142 (50.2%) in NN; 62 (21.9%) in NS; and 79 (27.9%) in SS. PCT values exhibited a parallel course in the three groups that peaked on the second postoperative day and returned to preoperative levels on the third day or later. The lowest PCT values were found in NN, and the highest values were observed in SS; the NS values were intermediate. Conclusions PCT kinetics coupled with a clinical examination may be helpful for sepsis diagnosis during the first days after burn injury and burn surgery.

Metallurgical and Materials Transactions A - An Al-5.8 at. pct Mg (5.2 wt pct Mg) alloy was deformed in torsion within the solute drag regime to various strains, up to the failure strain of 10.8....

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* Virus drives risk-averse trade in Asia * China GDP misses expectations, but domestic demand impresses * Powell testimony to continue By Tom Westbrook SINGAPORE, July 15 (Reuters) - Spiking coronavirus cases kept the dollar supported in Asia on Thursday and it clawed back a little of a drop which had followed insistence from Federal Reserve chair Jerome Powell that he isn't in a hurry to withdraw policy support. The dollar was up about half a percent on the New Zealand dollar by midday in Tokyo, up about 0.3% on the Australian dollar and British pound and up roughly 0.1% against the euro. Mixed economic data in China - showing a largely expected growth slowdown, but signs of more resilient domestic demand - also did little to improve the mood.

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