Pilot Programs in Medical Research

The U.S. Department of Energy's Office of Scientific and Technical Information

Pressure switch and thermostat with two control outputs and two stages, operating in pressurization, depressurization, refrigeration, heating, or alarm mod...

Complete solutions for high power semiconductor device characterization

Did you know that there is more then one way to stretch out your muscles?    We are going to look at 2 different types in this blog post - Static and Dynamic

A new approach to dynamic allocation and pricing that blends dynamic paradigms from the operations research and management science literature with classical mechanism design methods.Dynamic allocation and pricing problems occur in numerous frameworks, including the pricing of seasonal goods in retail, the allocation of a fixed inventory in a given period of time, and the assignment of personnel to incoming tasks. Although most of these problems deal with issues treated in the mechanism design literature, the modern revenue management (RM) literature focuses instead on analyzing properties of restricted classes of allocation and pricing schemes. In this book, Alex Gershkov and Benny Moldovanu propose an approach to optimal allocations and prices based on the theory of mechanism design, adapted to dynamic settings.Drawing on their own recent work on the topic, the authors describe a modern theory of RM that blends the elegant dynamic models from the operations research (OR), management science, and computer science literatures with techniques from the classical mechanism design literature. Illustrating this blending of approaches, they start with well-known complete information, nonstrategic dynamic models that yield elegant explicit solutions. They then add strategic agents that are privately informed and then examine the consequences of these changes on the optimization problem of the designer. Their sequential modeling of both nonstrategic and strategic logic allows a clear picture of the delicate interplay between dynamic trade-offs and strategic incentives. Topics include the sequential assignment of heterogeneous objects, dynamic revenue optimization with heterogeneous objects, revenue maximization in the stochastic and dynamic knapsack model, the interaction between learning about demand and dynamic efficiency, and dynamic models with long-lived, strategic agents.

Trying to change a variable name of an XDF with rxSetVarInfo. I want to merge several data sets with common var names. (I know rxMerge can/will append to filenames where needed. I want to have m...

Molecular docking is central to rational drug design. Current docking techniques suffer, however, from limitations in protein flexibility and solvation models and by the use of simplified scoring functions. All-atom molecular dynamics simulations, on the other hand, feature a realistic representation of protein flexibility and solvent, but require knowledge of the binding site. Recently we showed that coarse-grained molecular dynamics simulations, based on the most recent version of the Martini force field, can be used to predict protein/ligand binding sites and pathways, without requiring any a priori information, and offer a level of accuracy approaching all-atom simulations. Given the excellent computational efficiency of Martini, this opens the way to high-throughput drug screening based on dynamic docking pipelines. In this opinion article, we sketch the roadmap to achieve this goal.

Sepsis is a major cause of mortality and morbidity in critically ill patients. Procalcitonin (PCT) and C-reactive protein (CRP) are the most frequently used biomarkers in sepsis. We investigated changes in PCT and CRP concentrations in critically ill patients with sepsis to determine which biochemical marker better predicts outcome. We retrospectively analyzed 171 episodes in 157 patients with severe sepsis and septic shock who were admitted to the Samsung Medical Center intensive care unit from March 2013 to February 2014. The primary endpoint was patient outcome within 7 days from ICU admission (treatment failure). The secondary endpoint was 28-day mortality. Severe sepsis was observed in 42 (25%) episodes from 41 patients, and septic shock was observed in 129 (75%) episodes from 120 patients. Fifty-five (32%) episodes from 42 patients had clinically-documented infection, and 116 (68%) episodes from 99 patients had microbiologically-documented infection. Initial peak PCT and CRP levels were not associated with treatment failure and 28-day mortality. However, PCT clearance (PCTc) and CRP (CRPc) clearance were significantly associated with treatment failure (p = 0.027 and p = 0.030, respectively) and marginally significant with 28-day mortality (p = 0.064 and p = 0.062, respectively). The AUC for prediction of treatment success was 0.71 (95% CI, 0.61–0.82) for PCTc and 0.71 (95% CI, 0.61–0.81) for CRPc. The AUC for survival prediction was 0.77 (95% CI, 0.66–0.88) for PCTc and 0.77 (95% CI, 0.67–0.88) for CRPc. Changes in PCT and CRP concentrations were associated with outcomes of critically ill septic patients. CRP may not be inferior to PCT in predicting outcome in these patients.

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The longtime teammates and rivals hope to win a fifth gold medal with the U.S. later this summer in Tokyo.

Administrator's Guide to Sybase ASE 15 is a practical systems administration guide for the newest release of the ASE product. Designed to provide all administrators with an authoritative guide, topics include installation, defining physical and Sybase-mirrored devices, transaction logging and modes, security, auditing, database backup and restoration, troubleshooting, maintenance, and more. After reading this book, you should be able to perform any task that encompasses the creation or maintenance of a server. With this book any administrator will understand the responsibilities of a system administrator; find out how to set limits on server resources using the Resource Governor; learn how to prioritize tasks with the Logical Process Manager; use data partitioning to enable finer control over data placement, maintenance, and management.

Join PCT from the comfort of your home or office for this virtual conference dedicated to the topic of rodent control. Rodent control is quickly becoming one of the pest management industry’s most dynamic and profitable vertical market segments. In fact, 22 percent of PMPs report rodent control as their largest growth market, according to the 2019 PCT State of the Rodent Market, trailing only ants. There is also a significant amount of innovation occurring in the rodent control marketplace, including new and improved rodenticide formulations; the introduction of IoT-based rodent monitoring systems; and the latest advancements in trapping technology. If you’re thinking about expanding your rodent control service offerings or learning more about new opportunities in this dynamic marketplace, you won’t want to miss PCT’s Virtual Rodent Conference featuring many of the industry’s leading rodent experts on Wednesday, December 4th.

Apply for Manager, PCT License Partner Management (153564) job with Thermo Fisher Scientific in Massachusetts, United States. Marketing jobs at Thermo Fisher Scientific

I have a matrix where I have Product, Type, and Count. I would like to add a Pct of Total column as seen below where it shows Type's Pct of Total for each product.    Product Type Count Pct of Total 1 A 105 7%   B 231 16%   C 818 56%   D 307 21% 2 A 182 12%   B 555 36%   C 613 40%   D 201 13% 3 A 46...

Prepare to work under supervision to give focused nursing care to patients with predictable health care needs. After successfully completing our vocational nursing certificate program, you are eligible to sit for the certification exam.

The Official U.S. Senate website of Senator Ben Cardin of Maryland