Pilot Programs in Medical Research

Background To predict the prognosis by observing the dynamic change of C-reactive protein (CRP) and procalcitonin (PCT) for hospitalized community-acquired pneumonia (CAP). Methods The data were collected from January to December 2017 from the first affiliated Hospital of Zhengzhou University. Demographic and clinical patient information including age, length of hospital stay and Charlson Comorbidity Index (CCI) were recorded. Blood samples were taken for CRP, PCT, and white blood cell count (WBC). Receiver Operating Characteristic (ROC) curve was used to verify each biomarker’s association with the prognosis of pneumonia. Results A total of 350 patients were enrolled in the study. The 30-day mortality was 10.86%. Serial serum CRP3, CRP5, PCT3, PCT5 and PCT5c levels were statistically lower in CAP survivors than non-survivors. CRP3c

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Updating the imaging standard of care to include artificial intelligence as a second reader is one solution that takes some burden off individual physicians.

In order to simulate the dynamic P-C-T curves of the MmNi4.6Al0.2Fe0.2V0.03 alloy, a mathematical model has been established and solved numerically by…

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We determined the stability of the LiBH4/CeH2 composite system by dynamic pcT (pressure, composition, temperature) measurements by using different constant hydrogen flows and by extrapolating ln(pdes/p0) linearly to equilibrium at zero flow. During desorption, the reaction 6LiBH4 + CeH2 → 6LiH + CeB6 + 10H2 occurs, leading to a theoretical hydrogen capacity of the destabilized system of 7.4 mass %. Within the model used and by applying the Van ˈt Hoff equation, the following thermodynamic parameters were determined for the desorption: enthalpy of reaction ΔrH = (58 ± 3) kJ mol−1 H2 and entropy of reaction ΔrS = (113 ± 4) J K−1 mol−1 H2, leading to a decomposition temperature Tdec = (240 ± 32) °C at a hydrogen pressure of p0 = 1.01325 bar, compared with ΔrH = 74 kJ mol−1 H2 and ΔrS = 115 J K−1 mol−1 H2 (Tdec = 370 °C) for pure LiBH4.1

The tool signicantly helped inexperienced rads and rivaled cardiovascular imaging experts at spotting obstructive CAD.

Among the main electric components in power systems, load models have great effect on power system time- domain dynamic simulations. However, owing to the characteristics such as time-variation, randomness and so on, it is difficult to construct load model. In addition, in order to analyze the uncertainties, Monte-Carlo method is often used to estimate the probability density function of the desired output, which requires many sample data obtained from repeated simulations, therefore the uncertainty studies on power system stability are few. This paper studies the effect of the uncertainties of dynamic load proportion on power system dynamic stability based on Probabilistic Collocation Method (PCM). It could be concluded that using the proposed method the desired output is directly described as a polynomial in the uncertain parameter of the system. Consequently, high calculation accuracy could be reached by low-dimensionality polynomial functions and fewer time-domain simulations. Cases study verifies the validity of the proposed method.

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Objective: To investigate the diagnostic value of dynamic serum procalcitonin (PCT) level in recurrent infection and cut-off value for PCT. Method: From which such cases as voluntary discharge, death and generally accepted conditions affecting PCT levels were ruled out, leaving 300 cases taken into our research, including 200 cases of recurrent infection and 100 cases of effective treatment. The PCT levels for the recurrent cases were compared with those receiving effective treatment simultaneously. Furthermore, differences between PCT rebound points for the recurrent and those from 60 control cases were compared. The diagnostic performance of PCT, WBC count, and IL-6 for recurrent infection cases was evaluated using ROC curve. Results: The PCT level differed for cases with recurrent infections and those receiving effective treatment. The former demonstrated a rebound in PCT level. The PCT rebound point for recurrent cases was higher than that of the normal controls. The area under the ROC of PCT for the diagnosis of recurrent infection was 83.5%. The cut-off level corresponding to the optimal sensitivity (89%), specificity (83%), positive predictive value (84%), and negative predictive value (88.3%) was 2.29 ng·ml-1. However, the WBC count and IL-6 level had little diagnostic value for recurrent infection, and the area under the ROC curve was 55.1% and 61.0%, respectively. Conclusion: Dynamic monitoring of serum PCT levels had an important diagnostic and discriminatory value for recurrent infection induced by bacteria.

Abstract Pressure–composition–temperature (P–c–T) relations of the La-incorporated and fluorinated AB 2 alloy, Zr 0.9 Ti 0.1 V 0.2 Mn 0.6 Co 0.1 Ni 1.1 , were studied under isothermal dynamic conditions of 313 K and 343 K. The La-incorporation and fluorination effectively improved both the significant deviations existing in the static and dynamic P–c–T relations of conventional metal hydrides.

Objective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. Patients and Methods. An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. Serum sTREM-1, sCD163, PCT, CRP, and WBC counts were tested on days 1, 3, 5, 7, 10, and 14. Results. On the ICU admission, the sepsis group displayed higher levels of sTREM-1, sCD163, PCT, and CRP than the SIRS group ( ). Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. Both sCD163 and SOFA scores are risk factors impacting the survival time. Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor.

Delay embeddings of time series data have emerged as a promising coordinate basis for data-driven estimation of the Koopman operator, which seeks a linear representation for observed nonlinear...

Objective To investigate the prognostic significance of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with sepsis and those with septic sho...

Administrator's Guide to Sybase ASE 15 is a practical systems administration guide for the newest release of the ASE product. Designed to provide all administrators with an authoritative guide, topics include installation, defining physical and Sybase-mirrored devices, transaction logging and modes, security, auditing, database backup and restoration, troubleshooting, maintenance, and more. After reading this book, you should be able to perform any task that encompasses the creation or maintenance of a server. With this book any administrator will understand the responsibilities of a system administrator; find out how to set limits on server resources using the Resource Governor; learn how to prioritize tasks with the Logical Process Manager; use data partitioning to enable finer control over data placement, maintenance, and management.

Sepsis is a major cause of mortality and morbidity in critically ill patients. Procalcitonin (PCT) and C-reactive protein (CRP) are the most frequently used biomarkers in sepsis. We investigated changes in PCT and CRP concentrations in critically ill patients with sepsis to determine which biochemical marker better predicts outcome. We retrospectively analyzed 171 episodes in 157 patients with severe sepsis and septic shock who were admitted to the Samsung Medical Center intensive care unit from March 2013 to February 2014. The primary endpoint was patient outcome within 7 days from ICU admission (treatment failure). The secondary endpoint was 28-day mortality. Severe sepsis was observed in 42 (25%) episodes from 41 patients, and septic shock was observed in 129 (75%) episodes from 120 patients. Fifty-five (32%) episodes from 42 patients had clinically-documented infection, and 116 (68%) episodes from 99 patients had microbiologically-documented infection. Initial peak PCT and CRP levels were not associated with treatment failure and 28-day mortality. However, PCT clearance (PCTc) and CRP (CRPc) clearance were significantly associated with treatment failure (p = 0.027 and p = 0.030, respectively) and marginally significant with 28-day mortality (p = 0.064 and p = 0.062, respectively). The AUC for prediction of treatment success was 0.71 (95% CI, 0.61–0.82) for PCTc and 0.71 (95% CI, 0.61–0.81) for CRPc. The AUC for survival prediction was 0.77 (95% CI, 0.66–0.88) for PCTc and 0.77 (95% CI, 0.67–0.88) for CRPc. Changes in PCT and CRP concentrations were associated with outcomes of critically ill septic patients. CRP may not be inferior to PCT in predicting outcome in these patients.

Coronary artery disease (CAD) is a significant cause of morbidity and mortality. Evaluation of obstructive CAD involves quantifying arterial stenoses to determine whether significant narrowing is present. Lesions with stenosis more than 50 - 70% in diameter accompanied by symptoms are generally considered significant. It has been suggested that noninvasive measurement of fractional flow reserve (FFR) after a positive coronary computed tomography angiography (CCTA) may help rule out CAD and avoid invasive coronary angiography (ICA) in individuals with a low clinical likelihood of significant CAD.

The structural pest control industry consists of more than 19,000 pest management firms generating approximately $6.5 billion in annual revenue. One of the most stable segments of the U.S. economy, pest management professionals play a critical role in protecting the public’s health, food and property, providing valuable integrated pest management services to both residential and commercial customers. As the leading monthly trade publication serving this dynamic marketplace, PCT magazine is the industry’s "go-to" source for news and product information.

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