Pilot Programs in Medical Research

An experiment in education for medical and English Honours students was conducted during the 1983 academic year. Eight evening seminars were held, at which literary pieces were presented and discussed. All had relevance to medicine. No quantitative results could be deduced, but the voluntary attenda …

The fundamental role of the assumption of plane wave ultrasonic propagation in attenuation and scattering measurements on soft tissues is discussed. The evidence for and against the validity of the assumption is shown to be inconclusive. An experimental procedure for direct assessment, by measuremen …

Using double labeling techniques, we studied the replication of corneal epithelial stem cells that reside exclusively in the limbal zone, and their progeny transit amplifying cells. We show that corneal epithelial stem cells can be induced to enter DNA synthesis by wounding and by TPA. We demonstrat …

Slowly cycling label-retaining epidermal cells were identified by light microscopic autoradiography in the dorsal epidermis and hair follicles of adult mice 8-10 weeks after twice daily injection of [3H]dT on days three through five after birth. Pulse-labelled epidermal cells were identified in the …

In cultures of embryonic striatum, we previously reported that EGF induces the proliferation of single precursor cells, which give rise to spheres of undifferentiated cells that can generate neurons and glia. We report here that, in vitro, these embryonic precursor cells exhibit properties and satis …

A selected group of doctors were asked to state the number and names of the ingredients of several drug combinations they were accustomed to prescribe. The results indicate that among physicians there are serious gaps in their exact knowledge of the content of the preparations they order for their p …

During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally …

In both pediatric and adult patients, cranial radiation therapy causes a debilitating cognitive decline that is poorly understood and currently untreatable. This decline is characterized by hippocampal dysfunction, and seems to involve a radiation-induced decrease in postnatal hippocampal neurogenes …

A portable data recording system that works on the basis of a microcomputer has been developed. The main advantage of this system consists in the carrying out of checks for illogical and contradictory entries during the process of recording. False entries can immediately be corrected. The data are t …