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Cognitive load amplifies Parkinson's tremor through excitatory network influences onto the thalamus - PubMed
Cognitive load amplifies Parkinson's tremor through excitatory network influences onto the thalamus - PubMed
Parkinson's tremor is related to cerebral activity in both the basal ganglia and a cerebello-thalamo-cortical circuit. It is a common clinical observation that tremor markedly increases during cognitive load (such as mental arithmetic), leading to serious disability. Previous research has shown that …
·pubmed.ncbi.nlm.nih.gov·
Cognitive load amplifies Parkinson's tremor through excitatory network influences onto the thalamus - PubMed
Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype - PubMed
Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype - PubMed
Parkinson's disease is clinically defined by bradykinesia, along with rigidity and tremor. However, the severity of these motor signs is greatly variable between individuals, particularly the presence or absence of tremor. This variability in tremor relates to variation in cognitive/motivational imp …
·pubmed.ncbi.nlm.nih.gov·
Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype - PubMed
On the programming and reprogramming of actions - PubMed
Early-life and pubertal stress differentially modulate grey matter development in human adolescents - PubMed
Early-life and pubertal stress differentially modulate grey matter development in human adolescents - PubMed
Animal and human studies have shown that both early-life traumatic events and ongoing stress episodes affect neurodevelopment, however, it remains unclear whether and how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of early-life (age 0-5) and ongoing …
·pubmed.ncbi.nlm.nih.gov·
Early-life and pubertal stress differentially modulate grey matter development in human adolescents - PubMed
Communicative knowledge pervasively influences sensorimotor computations - PubMed
Communicative knowledge pervasively influences sensorimotor computations - PubMed
Referential pointing is a characteristically human behavior, which involves moving a finger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spati …
·pubmed.ncbi.nlm.nih.gov·
Communicative knowledge pervasively influences sensorimotor computations - PubMed
Cortical Oscillatory Mechanisms Supporting the Control of Human Social-Emotional Actions - PubMed
Cortical Oscillatory Mechanisms Supporting the Control of Human Social-Emotional Actions - PubMed
The human anterior prefrontal cortex (aPFC) is involved in regulating social-emotional behavior, presumably by modulating effective connectivity with downstream parietal, limbic, and motor cortices. Regulating that connectivity might rely on theta-band oscillations (4-8 Hz), a brain rhythm known to …
·pubmed.ncbi.nlm.nih.gov·
Cortical Oscillatory Mechanisms Supporting the Control of Human Social-Emotional Actions - PubMed
Delay-related cerebral activity and motor preparation - PubMed
Parieto-frontal connectivity during visually guided grasping - PubMed
Parieto-frontal connectivity during visually guided grasping - PubMed
Grasping an object requires processing visuospatial information about the extrinsic features (spatial location) and intrinsic features (size, shape, orientation) of the object. Accordingly, manual prehension has been subdivided into a reach component, guiding the hand toward the object on the basis …
·pubmed.ncbi.nlm.nih.gov·
Parieto-frontal connectivity during visually guided grasping - PubMed
Neural Control of Emotional Actions in Response to Affective Vocalizations - PubMed
Neural Control of Emotional Actions in Response to Affective Vocalizations - PubMed
Social-emotional cues, such as affective vocalizations and emotional faces, automatically elicit emotional action tendencies. Adaptive social-emotional behavior depends on the ability to control these automatic action tendencies. It remains unknown whether neural control over automatic action tenden …
·pubmed.ncbi.nlm.nih.gov·
Neural Control of Emotional Actions in Response to Affective Vocalizations - PubMed
Understanding communicative actions: a repetitive TMS study - PubMed
Understanding communicative actions: a repetitive TMS study - PubMed
Despite the ambiguity inherent in human communication, people are remarkably efficient in establishing mutual understanding. Studying how people communicate in novel settings provides a window into the mechanisms supporting the human competence to rapidly generate and understand novel shared symbols …
·pubmed.ncbi.nlm.nih.gov·
Understanding communicative actions: a repetitive TMS study - PubMed
Dopamine controls Parkinson's tremor by inhibiting the cerebellar thalamus - PubMed
Dopamine controls Parkinson's tremor by inhibiting the cerebellar thalamus - PubMed
Parkinson's resting tremor is related to altered cerebral activity in the basal ganglia and the cerebello-thalamo-cortical circuit. Although Parkinson's disease is characterized by dopamine depletion in the basal ganglia, the dopaminergic basis of resting tremor remains unclear: dopaminergic medicat …
·pubmed.ncbi.nlm.nih.gov·
Dopamine controls Parkinson's tremor by inhibiting the cerebellar thalamus - PubMed
Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum - PubMed
Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum - PubMed
Interactions between motivational, cognitive, and motor regions of the striatum are crucial for implementing behavioral control. Work with experimental animals indicates that such interactions are sensitive to modulation by dopamine. Using systematic pharmacological manipulation of dopamine D2-recep …
·pubmed.ncbi.nlm.nih.gov·
Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum - PubMed
Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system - PubMed
Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system - PubMed
This study uses electrocorticography in humans to assess how alpha- and beta-band rhythms modulate excitability of the sensorimotor cortex during psychophysically-controlled movement imagery. Both rhythms displayed effector-specific modulations, tracked spectral markers of action potentials in the l …
·pubmed.ncbi.nlm.nih.gov·
Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system - PubMed
Complementary systems for understanding action intentions - PubMed
Testosterone biases the amygdala toward social threat approach - PubMed
Testosterone biases the amygdala toward social threat approach - PubMed
Testosterone enhances amygdala reactions to social threat, but it remains unclear whether this neuroendocrine mechanism is relevant for understanding its dominance-enhancing properties; namely, whether testosterone biases the human amygdala toward threat approach. This pharmacological functional mag …
·pubmed.ncbi.nlm.nih.gov·
Testosterone biases the amygdala toward social threat approach - PubMed
The Effects of a TMS Double Perturbation to a Cortical Network - PubMed
The Effects of a TMS Double Perturbation to a Cortical Network - PubMed
Transcranial magnetic stimulation (TMS) is often used to understand the function of individual brain regions, but this ignores the fact that TMS may affect network-level rather than nodal-level processes. We examine the effects of a double perturbation to two frontoparietal network nodes, compared w …
·pubmed.ncbi.nlm.nih.gov·
The Effects of a TMS Double Perturbation to a Cortical Network - PubMed
GABAergic changes in the thalamocortical circuit in Parkinson's disease - PubMed
GABAergic changes in the thalamocortical circuit in Parkinson's disease - PubMed
Parkinson's disease is characterized by bradykinesia, rigidity, and tremor. These symptoms have been related to an increased gamma-aminobutyric acid (GABA)ergic inhibitory drive from globus pallidus onto the thalamus. However, in vivo empirical evidence for the role of GABA in Parkinson's disease is …
·pubmed.ncbi.nlm.nih.gov·
GABAergic changes in the thalamocortical circuit in Parkinson's disease - PubMed
Perceptuo-motor interactions during prehension movements - PubMed
Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling - PubMed
Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling - PubMed
Control over emotional action tendencies is essential for everyday interactions. This cognitive function fails occasionally during socially challenging situations, and systematically in social psychopathologies. We delivered dual-site phase-coupled brain stimulation to facilitate theta-gamma phase-a …
·pubmed.ncbi.nlm.nih.gov·
Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling - PubMed
Constructing Others' Beliefs from One's Own Using Medial Frontal Cortex - PubMed
Constructing Others' Beliefs from One's Own Using Medial Frontal Cortex - PubMed
Many daily choices are based on one's own knowledge. However, when predicting other people's behavior, we need to consider the differences between our knowledge and other people's presumed knowledge. Social agents need a mechanism to use privileged information for their own behavior but exclude it f …
·pubmed.ncbi.nlm.nih.gov·
Constructing Others' Beliefs from One's Own Using Medial Frontal Cortex - PubMed
Brain mechanisms underlying human communication - PubMed
The experience of fatigue in the brain - PubMed
Visuomotor processing is altered after peripheral nerve damage in neuralgic amyotrophy - PubMed
Visuomotor processing is altered after peripheral nerve damage in neuralgic amyotrophy - PubMed
Neuralgic amyotrophy is a common peripheral nerve disorder caused by autoimmune inflammation of the brachial plexus, clinically characterized by acute pain and weakness of the shoulder muscles, followed by motor impairment. Despite recovery of the peripheral nerves, patients often have residual moto …
·pubmed.ncbi.nlm.nih.gov·
Visuomotor processing is altered after peripheral nerve damage in neuralgic amyotrophy - PubMed
Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context - PubMed
Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context - PubMed
People are better at approaching appetitive cues signaling reward and avoiding aversive cues signaling punishment than vice versa. This action bias has previously been shown in approach-avoidance tasks involving arm movements in response to appetitive or aversive cues. It is not known whether appeti …
·pubmed.ncbi.nlm.nih.gov·
Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context - PubMed
Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson's tremor - PubMed
Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson's tremor - PubMed
Rest tremor in Parkinson's disease is related to cerebral activity in both the basal ganglia and a cerebello-thalamo-cortical circuit. Clinically, there is strong interindividual variation in the therapeutic response of tremor to dopaminergic medication. This observation casts doubt on the idea that …
·pubmed.ncbi.nlm.nih.gov·
Cerebral differences between dopamine-resistant and dopamine-responsive Parkinson's tremor - PubMed
Recipient design in tacit communication - PubMed
Comparable mechanisms for action and language: neural systems behind intentions, goals, and means - PubMed
Comparable mechanisms for action and language: neural systems behind intentions, goals, and means - PubMed
In this position paper we explore correspondence between neural systems for language and action starting from recent electrophysiological findings on the roles of posterior and frontal areas in goal-directed grasping actions. The paper compares the perceptual and motor organization for action and la …
·pubmed.ncbi.nlm.nih.gov·
Comparable mechanisms for action and language: neural systems behind intentions, goals, and means - PubMed
Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor - PubMed
Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor - PubMed
Dystonic tremor syndromes are highly burdensome and treatment is often inadequate. This is partly due to poor understanding of the underlying pathophysiology. Several lines of research suggest involvement of the cerebello-thalamo-cortical circuit and the basal ganglia in dystonic tremor syndromes, b …
·pubmed.ncbi.nlm.nih.gov·
Cerebello-thalamic activity drives an abnormal motor network into dystonic tremor - PubMed
Beyond the Isolated Brain: The Promise and Challenge of Interacting Minds - PubMed
Beyond the Isolated Brain: The Promise and Challenge of Interacting Minds - PubMed
As scientists, we brainstorm and develop experimental designs with our colleagues and students. Paradoxically, this teamwork has produced a field focused nearly exclusively on mapping the brain as if it evolved in isolation. Here, we discuss promises and challenges in advancing our understanding of …
·pubmed.ncbi.nlm.nih.gov·
Beyond the Isolated Brain: The Promise and Challenge of Interacting Minds - PubMed
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex - PubMed
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex - PubMed
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive avoidance, a trait that prevents learning through exposure. Although the origin of this failure is unclear, one candidate system involves control of emotional actions, coordinated through lateral frontopola …
·pubmed.ncbi.nlm.nih.gov·
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex - PubMed