Hi Sorry, this is going to be a post with many questions! I get worried about my OAB and my mind runs wild. I have overactive bladder (dry) without nocturia. I have suffered a lot of psychosomatic illnesses in my time as I've got a long history of anxiety.  I know my problem is somewhat physical as I suffer from orgasm incontinence (i.e. a little trickle of fluid at orgasm - what most people might think of as female ejaculation but I think it's now pretty much proven to be urine). The doctors have said they will be able to cure this but having had it for so long it sounds almost too good to be true! Has anyone else suffered from this and been cured? However, I'm wondering whether some of the sensations may be partly stress. I recently posted about having dark urine, for example, but when I went into the urologists recently my sample was completely colourless (how it was before the bladder problems) so, despite being convinced my urine was too dark, I think I must have focused on the times that it was and forgotten the times it wasn't due to anxiety about it (if you see what I mean!)  I don't want to suggest that OAB is psychosomatic but perhaps it is a little in my case. I've read about so-called 'nervous bladder', which is a psychosomatic condition that is relatively similar to OAB and wondered whether part of my problem is this. However, after a bit of research, I haven't found any help on how to treat nervous bladder. I'm on a waiting list for therapy but I've got another 18 months to wait yet (going by previous waiting lists I've been on!) So I just wondered if anyone knew what they can do for nervous bladder or if its just a case of waiting for the therapy? Is it worth me speaking with my urologist about nervous bladder? I really don't want to sound like I'm self-diagnosing (although I am!) because I'm embarrassed about doing that through the anxiety. Last question! (Sorry for length of post!) A lot of my symptoms are around the urethral opening (or between the urethral opening and vaginal opening), which has been swollen for a while. I meant to mention this to the urologist last time I was there but I was embarrassed because they've done gynaecological assessments and have never mentioned swelling there so I thought it might be in my mind. However, right at the vaginal opening is where I get most of my symptoms during sex. Pressure on the front wall of the vagina about 1cm into the vagina (a few cms lower than the "g-spot") produces an urgent need to urinate. Sometimes it feels like I am urinating but nothing comes out. This isn't an orgasm thing, by the way, this is immediately as we have sex, before any pleasure has started! Again, I might be overly focusing on this feeling or imagining it so I'll give it the benefit of the doubt but I wondered if anyone could shed any light on swelling in that area and whether its worth mentioning to the doctors. A few months before I was referred to a urologist, the area between my urethral and vaginal openings was bulbous and purple, so perhaps I've just got that in my mind, but this discolouration and most of the swelling had gone by the time I was examined and has remained mild since. Sorry again for the long post, I do get worried about this!  Thanks

Benefits of orgasm include boosting mood, strengthening relationships, and even helping you sleep.

Practical, standardized tools to assess and document functioning, disability, and health according to the WHO ICF in a variety of health conditions and settings

Coital incontinence occurs during sexual intercourse, and is commonly experienced in sexually active women that suffer from another form of urinary incontinence. Learn more in our article.

Male or female, physical therapy and pelvic floor exercises can fix your bladder control issues.

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Official website of Harvard professor of psychiatry, John E. Mack, M.D., exploring the frontiers of human experience.

Experiencer narratives must be seriously considered as humanity struggles to come to terms with the profound implications of UAP sightings and contact encounters.

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Hematopoietic stem cells maintain a quiescent state in the bone marrow to preserve their self-renewal capacity, but also undergo cell divisions as required. Organelles such as the mitochondria sustain cumulative damage during these cell divisions and this damage may eventually compromise the cells' …

Mechanotransduction: May the force be with you

Speed-accuracy trade-off (SAT) is the tendency for decision speed to covary with decision accuracy. SAT is an inescapable property of aimed movements being present in a wide range of species, from insects to primates. An aspect that remains unsolved is whether SAT extends to plants' movement. Here, …

Cell adhesion systems are defined by their ability to resist detachment force. Our understanding of the biology of cell-cell adhesions has recently been transformed by the realization that many of the forces that act on those adhesions are generated by the cells that they couple together; and that f …

In trying to explain the myriad of foot deformities and symptoms that have slow onset and/or are considered to be overuse syndromes, clinicians have been trying to develop quantitative examinations to describe the cause of the patient's problems and to better individualize treatment modalities. This …

Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical informat …

Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional and other cellular responses. Here, we describe recent advances in the field of mechanical regulation of transcription, highlig …

Immune cells including B and T lymphocytes have a remarkable ability to sense the physical perturbations through their surface expressed receptors. At the advent of modern imaging technologies paired with biophysical methods, we have gained the understanding of mechanical forces exerted by immune ce …

Odontoblasts are post-mitotic cells organized as a layer of palisade cells along the interface between the dental pulp and dentin. They are responsible for the formation of the physiological primary and secondary dentins. They synthesize the organic matrix of type I collagen and actively participate …

We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.

Physical forces are central players in development and morphogenesis, provide an ever-present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical …