REHAB ISN'T FOR WINNERS, LOSER

Benefits of orgasm include boosting mood, strengthening relationships, and even helping you sleep.

Practical, standardized tools to assess and document functioning, disability, and health according to the WHO ICF in a variety of health conditions and settings

Coital incontinence occurs during sexual intercourse, and is commonly experienced in sexually active women that suffer from another form of urinary incontinence. Learn more in our article.

Male or female, physical therapy and pelvic floor exercises can fix your bladder control issues.

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As verbs the difference between imaging and imagining is that imaging is while imagining is...

Leadership Matters. Character Matters. At the McCain Institute for International Leadership, we are fighting to secure democracy and alliances, defend human rights, protect the vulnerable and advance character-driven leadership, both at home and around the world. Play Video https://youtu.be/M9ShfUAjNgghttps://vimeo.com/704962351 Our Guiding Principles Advancing Democracy, Alliances and Security National Security & Counterterrorism Reaffirming America’s Strategic Alliances […]

Official website of Harvard professor of psychiatry, John E. Mack, M.D., exploring the frontiers of human experience.

Experiencer narratives must be seriously considered as humanity struggles to come to terms with the profound implications of UAP sightings and contact encounters.

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Where we go one, we go all.

Hematopoietic stem cells maintain a quiescent state in the bone marrow to preserve their self-renewal capacity, but also undergo cell divisions as required. Organelles such as the mitochondria sustain cumulative damage during these cell divisions and this damage may eventually compromise the cells' …

Mechanotransduction: May the force be with you

Speed-accuracy trade-off (SAT) is the tendency for decision speed to covary with decision accuracy. SAT is an inescapable property of aimed movements being present in a wide range of species, from insects to primates. An aspect that remains unsolved is whether SAT extends to plants' movement. Here, …

Cell adhesion systems are defined by their ability to resist detachment force. Our understanding of the biology of cell-cell adhesions has recently been transformed by the realization that many of the forces that act on those adhesions are generated by the cells that they couple together; and that f …

In trying to explain the myriad of foot deformities and symptoms that have slow onset and/or are considered to be overuse syndromes, clinicians have been trying to develop quantitative examinations to describe the cause of the patient's problems and to better individualize treatment modalities. This …

Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity. Mechanical stresses are tensorial in nature, and thus provide dual mechanical informat …

Mechanotransduction is the ability of a cell to sense mechanical cues from its microenvironment and convert them into biochemical signals to elicit adaptive transcriptional and other cellular responses. Here, we describe recent advances in the field of mechanical regulation of transcription, highlig …

Immune cells including B and T lymphocytes have a remarkable ability to sense the physical perturbations through their surface expressed receptors. At the advent of modern imaging technologies paired with biophysical methods, we have gained the understanding of mechanical forces exerted by immune ce …

Odontoblasts are post-mitotic cells organized as a layer of palisade cells along the interface between the dental pulp and dentin. They are responsible for the formation of the physiological primary and secondary dentins. They synthesize the organic matrix of type I collagen and actively participate …

We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.

Physical forces are central players in development and morphogenesis, provide an ever-present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical …

Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung, urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human body and its specific roles have been identified following a decade of research; however, not all are well understood. …

Muscle contraction is a three-dimensional process, as anyone who has observed a bulging muscle knows. Recent studies suggest that the three-dimensional nature of muscle contraction influences its mechanical output. Shape changes and radial forces appear to be important across scales of organization. …