Holographic Medical Pods (Med Beds) – Era of Light
Writer’s Note: Med Bed technology has been “suppressed” and hidden from the public for a long, long time. Fortunately, due to the planetary shift from 3D to 5D happening at this time, and the incre…
Smart medical beds in patient-care environments of the twenty-first century: a state-of-art survey | BMC Medical Informatics and Decision Making | Full Text
Background Recent scientific achievements and technological advances have brought forward a massive display of new or updated medical devices, enabled with highly-developed embedded-control functions and interactivity. From the final decade of the twentieth century, medical beds have particularly been affected by this surge, taking on new forms and functions, while accommodating to established properties that have become well-known for these devices. The past fifteen years have also brought forward changes to conceptual frameworks, concerning the product design and manufacturing processes (standards), as well as the patient (perspectives on patient-care environments and accessibility). This work presents a state-of-art survey on electric medical beds, representing what is defined as the time of “smart beds”, as part of an increasingly comprehensive patient-care environment. Methods A survey and assessment of market trends, research efforts and standards related to smart medical beds was performed, covering a wide range of public records of intellectual property, models and related healthcare solutions, as well as relevant research efforts in the field between 2000 and 2016. Contextual topics, necessary for the understanding of this subject, on novel technologies, disability and the reach of healthcare systems, were also researched and interpreted. Results The new generation of electric medical beds is defined, with the final stage of the proposed timeline for these devices being covered. Functional, aesthetic and interactive features are presented, and the current global market for medical beds and related standards are also assessed. Finally, discussions concerning rising challenges and opportunities for these systems are explored, with the potential for adding further monitoring and assistive implementations into medical devices and environments being highlighted. Conclusions Smart medical beds are integrated solutions for patient care, assistance and monitoring, based on a comprehensive, multidisciplinary design approach. Research in this field is critical in a context of global ageing, and powered by a surge in opportunities for accessibility solutions. Smart beds, seamlessly integrated into the healthcare system, have a unique opportunity in enabling more efficient efforts for caregivers, and more responsive environments for patients.
Enhancing Social Presence in Augmented Reality-Based Telecommunication System | SpringerLink
The main contribution of this paper is to examine the new method of augmented reality from a telecommunication point of view. Then, we tried to present the fact that the concept of social presence is an important cue for developing telecommunication system based on...
Virtual Interactive Presence and Augmented Reality (VIPAR) for Remote Surgical Assistance | Semantic Scholar
The VIPAR system allowed for real-time, virtual interaction between a local (resident) and remote (attending) surgeon, and MRI augmentation provided spatial guidance to both surgeons. BACKGROUND: Surgery is a highly technical field that combines continuous decision-making with the coordination of spatiovisual tasks. OBJECTIVE: We designed a virtual interactive presence and augmented reality (VIPAR) platform that allows a remote surgeon to deliver real-time virtual assistance to a local surgeon, over a standard Internet connection. METHODS: The VIPAR system consisted of a “local” and a “remote” station, each situated over a surgical field and a blue screen, respectively. Each station was equipped with a digital viewpiece, composed of 2 cameras for stereoscopic capture, and a high-definition viewer displaying a virtual field. The virtual field was created by digitally compositing selected elements within the remote field into the local field. The viewpieces were controlled by workstations mutually connected by the Internet, allowing virtual remote interaction in real time. Digital renderings derived from volumetric MRI were added to the virtual field to augment the surgeon's reality. For demonstration, a fixed-formalin cadaver head and neck were obtained, and a carotid endarterectomy (CEA) and pterional craniotomy were performed under the VIPAR system. RESULTS: The VIPAR system allowed for real-time, virtual interaction between a local (resident) and remote (attending) surgeon. In both carotid and pterional dissections, major anatomic structures were visualized and identified. Virtual interaction permitted remote instruction for the local surgeon, and MRI augmentation provided spatial guidance to both surgeons. Camera resolution, color contrast, time lag, and depth perception were identified as technical issues requiring further optimization. CONCLUSION: Virtual interactive presence and augmented reality provide a novel platform for remote surgical assistance, with multiple applications in surgical training and remote expert assistance.
Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal pattern recognition receptors that detect a variety of single-stranded RNA species. While TL…
Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-κB signaling pathways - ScienceDirect
Toll-like receptor (TLR) 2 is a key regulator of innate immune responses and has been shown to play an important role in inflammation-associated cance…
The ability of the ocular surface to respond to pathogens is in part attributed to toll-like receptors (TLRs) that recognize conserved motifs on vario…
Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword - ScienceDirect
Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various pathogen- and damage-associated molecular pattern molecules …
Primary Endpoint Analysis of a Randomized Phase III Trial of Hypofractionated vs. Conventional Post-Prostatectomy Radiotherapy: NRG Oncology GU003 - International Journal of Radiation Oncology, Biology, Physics
To determine if hypofractionated post-operative prostate bed radiotherapy (HYPORT) does not increase patient-reported genitourinary (GU) or gastrointestinal (GI) toxicity over conventionally fractionated post-operative radiotherapy (COPORT).
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology | PNAS
Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The pathogenesis of this neurodegenerative disease, currently without curative treatment, is associated with the accumulation of amyloid β (Aβ) in brain parenchyma and cerebral vasculature. AD patients are unable to clear this toxic peptide, leading to Aβ accumulation in their brains and, presumably, the pathology associated with this devastating disease. Compounds that stimulate the immune system to clear Aβ may therefore have great therapeutic potential in AD patients. Monophosphoryl lipid A (MPL) is an LPS-derived Toll-like receptor 4 agonist that exhibits unique immunomodulatory properties at doses that are nonpyrogenic. We show here that repeated systemic injections of MPL, but not LPS, significantly improved AD-related pathology in APPswe/PS1 mice. MPL treatment led to a significant reduction in Aβ load in the brain of these mice, as well as enhanced cognitive function. MPL induced a potent phagocytic response by microglia while triggering a moderate inflammatory reaction. Our data suggest that the Toll-like receptor 4 agonist MPL may be a treatment for AD.
Toll-Like Receptor-Based Strategies for Cancer Immunotherapy
Toll-like receptors (TLRs) are expressed and play multiple functional roles in a variety of immune cell types involved in tumor immunity. There are plenty of data on the pharmacological targeting of TLR signaling using agonist molecules that boost the ...
Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice
Bruton's tyrosine kinase (Btk), a member of the Tec family of tyrosine kinases, plays an important role in the differentiation and activation of B cells. Mutations affecting Btk cause immunodeficiency in both humans and mice. In this study we set out ...
Impact of Toll-like Receptor 4 Stimulation on Human Neonatal Neutrophil Spontaneous Migration, Transcriptomics, and Cytokine Production
Neonates rely on their innate immune system, and neutrophils in particular, to recognize and combat life-threatening bacterial infections. Pretreatment with lipopolysaccharide (LPS), a toll-like receptor (TLR) 4 agonist, improves survival to polymicrobial ...
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The Infamous Yang Cycle + AutoImmunity
