Phosphorylation analysis by using phos-tag technique has been reported to be suitable for highly sensitive quantification of smooth muscle myosin regulatory light chain (LC20) phosphorylation. Howeve...

Describes principles important to consider when developing drug abuse prevention programs and discusses issues relevant for family, school, and community settings.

Abstract. The human SMN2 transgenic mice are well-established models of spinal muscular atrophy (SMA). While the severe type I mouse model has a rapidly progres

Discover the 10 steps needed for a well conducted intervention: Get help, Form the intervention team, Make a plan, Gather information, Write impact statements, Offer help, Set boundaries, Rehearse, Manage expectations, Follow up.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): We describe current research that applies epigenetics to a novel understanding of the immuno-neuropathogenesis of HIV-1 viral infection and NeuroAIDS. We propose the hypothesis that HIV-1 alters the structure-function relationship of chromatin, coding DNA and non-coding DNA, including RNA transcribed from these regions resulting in pathogenesis in AIDS, drug abuse, and NeuroAIDS. We discuss the general implications of molecular epigenetics with special emphasis on drug abuse, bar-codes, pyknons, and miRNAs for translational and clinical research. We discuss the application of the recent recursive algorithm of