When you feel mentally and emotionally strong, you bring your best self to all your relationships—these tips, tools and approaches from Kaiser Permanente can help.

Learn how this imaging scan can play an important role in early detection of health problems, such as cancer, heart disease and brain disorders.

Nature Reviews Clinical Oncology - PET or SPECT, is that the question? Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are both tomographic techniques that...

Frequently asked questions by the health professionals » How can I know patient dose while using the C-arm in an operating theatre? » Should the X-ray tube be positioned closer to the patient or further away from the patient during fluoroscopy? » Does a patient’s physique have an effect on radiation dose to the patient and staff? » How effective is a reduction in fluoroscopy time in reducing dose to the patient and staff? » Is there a difference between a single long fluoroscopy and several shorter fluoroscopies with same total doses? » How should I select the pulse frequency in pulsed fluoroscopy? » Does the use of shielding have an effect on a patient’s radiosensitive organ dose? » Should termination of pregnancy be considered after a fluoroscopically guided procedure? » What is the magnitude of patient doses associated with fluoroscopically guided procedures? » Key points to remember in patient dose management in fluoroscopy.

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Nuclear Medicine and Molecular Imaging - Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation...

Nuclear medical imaging such as single-photon emission computed tomography (SPECT) and positron emission computed tomography (PET) have become important tools i...

The HeartMath Inner Balance app for Android and iPhone is an innovative approach to improving well-being, emotional coherence, building resilience and reducing stress. Inner Balance shows you your heart rhythm pattern (HRV) training you to change your heart rhythm pattern to a healthier, coherent state. Great for meditation and focus. Helps with managing stress, anxiety, depression and negativity.

Dopamine, serotonin and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research since modulation of their production and their interaction at monoamine receptors ...

Seriously, are they? Surprise - YES! Learn the truth about these dangerous synthetic chemicals today

After decades of opposition, a resurgence of interest in the psychotherapeutic potential of LSD is gaining acceptance in the medical community. Future acceptance of LSD as a psychotherapeutic adjuvant may be predicated on knowledge about its neural mechanisms of action. Preclinical drug discrimination assay offers an invaluable model to determine the neural mechanisms underlying LSD’s interoceptive stimulus effects. Unfortunately, current preclinical literature on LSD discrimination is based on results obtained exclusively in male subjects. The present study represents the first known preclinical assessment of possible sex differences in the discriminative stimulus effects of LSD. Adult female (n=8) and male (n=8) Sprague-Dawley rats were trained to discriminate 0.08 mg/kg LSD from saline under a fixed ratio 20 schedule of food reinforcement. Once discrimination was established, substitution tests were conducted with other hallucinogens (mescaline, DOM, psilocybin), mixed psychedelic-stimulants (MDMA, (+)-MDMA, (-)-MDMA, (+)-MDA, (-)-MDA), synthetic cathinones (MDPV, mephedrone) and psychostimulants (cocaine, amphetamine). Antagonist tests were conducted with serotoninergic antagonists (WAY 100,635, MDL 100,907, pirenperone) and dopaminergic antagonists (haloperidol, SCH 23390). Stimulus substitution results indicate higher levels of LSD-substitution with other serotonergic hallucinogens in females compared to males and some evidence for sex differences in the level of partial substitution by synthetic cathinones and the enantiomers of MDMA and MDA. Specifically, greater partial substitution was observed with (±)-MDMA, (+)MDMA, and (+)-MDA, in males and greater partial substitution was observed with (-)-MDMA , (-)-MDA, MDPV, and 4-MMC in females. Dopamine antagonists failed to block LSD in either males or females, but had stronger rate suppressant effects in males. The 5-HT2A antagonist, MDL 100,907 blocked LSD discrimination in both males and females, although complete blockade was evident at lower doses in males. These results suggest the relative contribution of serotonergic versus dopaminergic activity to the LSD cue varies between males and females. These findings may be informative for future investigations with human populations regarding possible sex differences in the subjective effects of LSD.

"New Emerging Psychoactive Substances: A Brief History and Pharmacology of 'Designer Drugs'" Presented by: Lisa Marzilli, PharmD, CDOE Abstract: The purpose of this educational lecture is to discuss current trends in "designer drugs" and issues surrounding these new and emerging products. The topic will be broken down categorically, addressing various classes of drugs based upon their mechanism of action. The categories that will be reviewed include: synthetic cannabinoids and synthetic...