America's Book Of Secrets: DARPA's Secret Mind Control Technology (Season 4) | History - YouTube
The Defense Advanced Research Projects Agency (DARPA) sets out on an initiative to develop nonsurgical neurotechnology - also used for mind control, in this ...
DARPA homes in on paper clip-sized implant for mind-controlled prosthetics | Fierce Biotech
Mind-controlled prosthetics are all the rage in med tech, and now, Australian scientists are taking the technology a step further. Scientists in a project funded by the U.S. military are developing a device the size of a paper clip that can transmit brain signals, potentially paving the way for new discoveries in the field. | Mind-controlled prosthetics is all the rage in med tech, and now, Australian scientists are taking the technology a step further. Scientists in a project funded by the U.S. military are developing a device the size of a paper clip that can transmit brain signals, potentially paving the way for new discoveries in the field.
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative health solutions for all.
DARPA targets prostheses that offer sensation; researchers aim to get there in 5 years with $20M | Fierce Biotech
The U.S. Defense Advanced Research Projects Agency (DARPA) has made the creation of upper-limb prosthesis, artificial arms and hands that allow for sensory feedback a top priority--it's backing 8 research organizations to do so. | The U.S. Defense Advanced Research Projects Agency (DARPA) has made the creation of upper-limb prosthesis, artificial arms and hands that allow for sensory feedback a top priority--it's backing 8 research organizations to do so.
Graphene sensors from Darpa measure and stimulate neural tissue at the same time using both electri… | Brain structure, Physics and mathematics, Electrical projects
FDA regulation of invasive neural recording electrodes: a daunting task for medical innovators - PubMed
The U.S. Food and Drug Administration (FDA) is charged with assuring the safety and effectiveness of medical devices. Before any medical device can be brought to market, it must comply with all federal regulations regarding FDA processes for clearance or approval. Navigating the FDA regulatory proce …
Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound - PubMed
Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric particle systems have emerged as non-genetic and wireless alternatives for electrode-based tethered stimulation syste …
Bi-directional electrical recording and stimulation of the intact retina with a screen-printed soft probe: a feasibility study - PubMed
These results demonstrate the unique performances of the new probe while also suggesting that intact retinas retain better stability and robustness than ex-vivo retinas making them more suitable for characterizing retina responses to electrical stimulation.
Programmable DNA-augmented hydrogels for controlled activation of human lymphocytes - PubMed
Contractile forces within the planar interface between T cell and antigen-presenting surface mechanically stimulate T cell receptors (TCR) in the mature immune synapses. However, the origin of mechanical stimulation during the initial, i.e., presynaptic, microvilli-based TCR activation in the course …
Sequencing XMET genes to promote genotype-guided risk assessment and precision medicine - PubMed
High-throughput next generation sequencing (NGS) is a shotgun approach applied in a parallel fashion by which the genome is fragmented and sequenced through small pieces and then analyzed either by aligning to a known reference genome or by de novo assembly without reference genome. This technology …
The Effect of Including Quantitative Information on Multiple Endpoints in Direct-to-Consumer Prescription Drug Television Advertisements - PubMed
Background. Previous research found that adding a single piece of quantitative information about prescription drug benefits to direct-to-consumer (DTC) ads helps consumers understand how well the drug works. However, drug information often includes quantitative information on multiple benefit …
Disclosing accelerated approval on direct-to-consumer prescription drug websites - PubMed
Direct-to-consumer websites for brand-name accelerated approval prescription drugs do not consistently communicate the accelerated approval information for the product to consumers in a prominent, comprehensive, or readable manner.
International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment - PubMed
To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 drugs linked to low, intermediate, and high torsades de point …
Designing cancer immunotherapy trials with random treatment time-lag effect - PubMed
In some clinical settings such as the cancer immunotherapy trials, a treatment time-lag effect may be present and the lag duration possibly vary from subject to subject. An efficient study design and analysis procedure should not only take into account the time-lag effect but also consider the indiv …
Broadband characterization of plastic and high intensity therapeutic ultrasound phantoms using time delay spectrometry-With validation using Kramers-Kronig relations - PubMed
Time delay spectrometry (TDS) is extended for broadband characterization of plastics (low-density polyethylene, LDPE) and tissue-mimicking material (TMM). The results suggest that TDS and the conventional broadband pulse method give comparable measurements for frequency-dependent attenuation coeffic …
Directivity and Frequency-Dependent Effective Sensitive Element Size of Needle Hydrophones: Predictions From Four Theoretical Forms Compared With Measurements - PubMed
Directivity is a hydrophone specification that describes response as a function of angle of incidence. The goal of this study was to compare, in the context of needle hydrophones, the commonly used rigid baffle model for hydrophone directivity to three alternative models: soft baffle, unbaffled (UB) …
Nicotine and addiction beliefs and perceptions among the US-born and foreign-born populations - PubMed
Little is known about nicotine and addiction beliefs held by those who are foreign-born in the US and how these beliefs are associated with acculturation and race/ethnicity. This study attempts to address these research gaps. Data were analyzed from two cycles of the Health Information National Tren …
Trends and economic drivers for United States naloxone pricing, January 2006 to February 2017 - PubMed
Anecdotal evidence indicates that naloxone prices have risen in recent years, but limited research has examined the magnitude of these increases and potential causes. We contribute nationally representative evidence to help answer each of these questions, including wholesale pricing data from a prop …
Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation - PubMed
This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volum …
Evaluating the Use of KIM-1 in Drug Development and Research Following FDA Qualification - PubMed
The Biomarker Qualification Program was established at the Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA) to expedite the integration of promising biomarkers across multiple drug development programs. The first set of biomarkers qualified in 2008 consisted of seve …
Drug Information Association Pharmacovigilance and Risk Management Strategies 2017: Overview of the Generic Drug Program and Surveillance - PubMed
The US Food and Drug Administration's (FDA's) generic drug program has dramatically increased the availability of affordable, high quality generic drugs. The foundation of generic drug approvals is a two-tiered regulatory framework of pharmaceutical equivalence and bioequivalence. Intrinsic to both …