Aim: To evaluate the potential use of zinc chelation for prostate cancer therapy using a new liposomal formulation of the zinc chelator, N,N,N’,N’-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN). Materials & methods: TPEN was encapsulated in nontargeted liposomes or liposomes displaying an aptamer to target prostate cancer cells overexpression prostate-specific membrane antigen. The prostate cancer selectivity and therapeutic efficacy of liposomal (targeted and nontargeted) and free TPEN were evaluated in vitro and in tumor-bearing mice. Results & conclusion: TPEN chelates zinc and results in reactive oxygen species imbalance leading to cell death. Delivery of TPEN using aptamer-targeted liposomes results in specific delivery to targeted cells. In vivo experiments show that TPEN-loaded, aptamer-targeted liposomes reduce tumor growth in a human prostate cancer xenograft model.

Below is a list of cornhole lingo used by cornhole players during a game or tournament. Some cornhole lingo is used often and some is rarely or never used.

Biogen shares fell Friday after the head of the FDA called for an investigation into the recent approval of the company's Alzheimer's drug, Aduhelm.

The use of antiretroviral therapy has reduced mortality and increased the quality of life of HIV-1-infected people, particularly in more developed countries where access to treatment is more widespread. However, morbidities continue, which include HIV-1-associated neurocognitive disorders (HAND). Subtle cognitive abnormalities and low-level viral replication underlie disease. The balance between robust antiviral adaptive immunity, neuronal homeostatic mechanisms, and neuroprotective factors on one hand and toxicities afforded by dysregulated immune activities on the other govern disease.

ASHA developed the following ICD-10-CM (International Classification of Diseases, 10th Revision, Clinical Modification) resources specifically for audiologists and speech-language pathologists. Contact reimbursement@asha.org for ICD-10-CM coding questions related to audiology and speech-language pathology services.

The research will continue to define the understanding of addiction. As public knowledge deepens, it should yield not only additional insight into substance abuse but should also give addiction professionals new tools to diagnose these disorders. This article examines a number of behavioral assessment tools available to help addiction specialists identify substance abuse issues. Which […]

There is a tragically close connection between addiction and emergency responders, who often turn to alcohol or drugs to cope and socialize.

U.S. Patent Application 20200390360 for Automatic Machine for Identifying Victim of Abuse Voice to Skull and Remote Neural Monitoring Technology and for Identifying Remote Attacker or Operator Using Device of Voice to Skull and Remote Neural Monitoring

4–1C On a P-v diagram, what does the area under the process curve represent? Get 4.1 exercise solution 4–2C Is the boundary work assoc...

Back to Blog Page Link: DARPA,Naval Research Labs etc.-PDF Files-Unclassified damning evidence(V2K-voice to skull weapons) & nanotech frequency tech. Pdf. Docs DOWNLOAD LINK MIND WEAPONDARPA &#…

Are you a multitasker? Does multitasking make you more productive? Learn why multitasking can impair efficiency and even hurt brain health.

A Dynamic Analysis Test can find vulnerabilities in enterprise web applications using the same techniques attackers would use. Learn more.

Learn about the best 10 configuration management tools and the pros and cons of each so you can figure out which is best fit for your DevOps organization.

For a list of all PUBLICATIONS on prevention of drug use and treatment, care and rehabilitation of drug dependence, please click here .

Since 1984 Trace Elements has been recognized internationally as a leading provider of hair tissue mineral analysis (HTMA or hair mineral analysis) laboratory services and nutritional metabolic products for doctors and health professionals of all specialties worldwide.

Welcome to the modern era of cyber exposure. Join the movement.

The Liver's energy moves outward and upward, mimicking the branches of a tree. Support this organ system in Spring—the season where its energy is at its peak.

Dr Rauni Kilde, M.D. was the Chief Medical Officer for Northern Finland, where she became aware of the government's Gangstalking program.  She wrote a book exposing the Targeted Individual program,...

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MIT Used a Laser to Transmit Audio Directly into a Person's Ear Futurism , Kristin Houser, January 25, 2019 Scientists have figured out how to use a laser to transmit audio, ranging from music to...

This short e-learning course covers key aspects of drug-related deaths in Scotland, how to identify an overdose, how to respond to an overdose and describes naloxone and its use. By the end of this...

Substance abuse, especially alcohol drinking and tobacco smoking, is highly prevalent in the HIV-infected population. HIV medication using antiretrovi…