Computer Store Owner John Paul Mac Isaac Releases Book Tuesday on Hunter Biden Laptop: "American Injustice: My Battle to Expose the Truth"
John Paul Mac Isaac is an American hero who was caught in the middle of one of the country’s biggest scandals – Hunter Biden’s laptop. John Paul Mac Isaac didn’t think he would ever be able to tell his story. When the word got out that he was responsible for handing the Hunter Biden laptop…
Reporter Robbed Live on Air in Qatar During World Cup
The world has descended on Qatar for the World Cup. During a broadcast, Argentinian reporter Dominique Metzger was dancing with revelers when she was robbed live on air. Image: Screenshot Twitter @Daily_Record The Daily Mail reports: A female Argentinian television reporter was robbed live on air while reporting in Qatar on the World Cup, with money…
Novel spinal pathways identified by neuronal c-Fos expression after urethrogenital reflex activation in female guinea pigs - ScienceDirect
Pudendal nerve-spinal pathways are involved in urethrogenital sensation, pain and sexual activity. However, details of these pathways and their modula…
SEMINAL VESICLE ASPIRATION IN SPINAL CORD INJURED MEN: INSIGHT INTO POOR SPERM QUALITY - ScienceDirect
In men with spinal cord injury poor quality semen is seen when performing electroejaculation and penile vibratory stimulation. We determined whether s…
No-scalpel vasal sperm aspiration and in vitro fertilization for the treatment of anejaculation - ScienceDirect
Objectives. To evaluate the utility of no-scalpel vasal sperm aspiration and in vitro fertilization for the treatment of male infertility due to aneja…
Cytotoxicity of Direct Current with Antibacterial Agents against Host Cells In Vitro - ScienceDirect
The purpose of this study was to investigate the cytotoxicity of iontophoresis treatment using direct current (DC) with or without antibacterial agent…
Role of Free Radicals and Metal Ions in Direct Current-Induced Cytotoxicity - ScienceDirect
The purpose of this study was to investigate the mechanism of direct current (DC)-induced cytotoxicity. To test the working hypothesis that electrolys…
The Effect on Semen Quality of the Electrical Current and Heat Generated During Rectal Probe Electroejaculation - ScienceDirect
Rectal probe electroejaculation is effective in procuring sperm from spinal cord injured patients with ejaculatory incompetence. The seminal quality i…
Electrolysis-induced myocardial dysfunction: A novel method for the study of free radical mediated tissue injury - ScienceDirect
Oxygen-derived free radicals and other oxidizing species are thought to be involved in inflammation and ischemic tissue injuries. Recently, oxygen-der…
Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. - ScienceDirect
Red blood cells (RBC) are thought to be well protected against oxidative stress by the antioxidant, cu-pro-zinc enzyme superoxide dismutase (CuZn SOD)…
Neurogenic voiding dysfunction : Current Opinion in Urology
ystem for the pathophysiology of neurogenic lower urinary tract dysfunction (NLUTD) which combines neurological defect in a distinct anatomic location, and data on bowel dysfunction, autonomic dysreflexia and urine biomarkers; review of patient-reported outcome measures in NLUTD; review of the criteria for the diagnosis of clinically significant urinary infections; novel research findings on the pathophysiology of NLUTD; and review of data on minimally and more invasive treatments. Summary Despite the extended evidence base on NLUTD, there is a paucity of high-quality new research concerning voiding dysfunction as opposed to storage problems. The update aims to inform clinicians about new developments in clinical practice, as well as ignite discussion for further clinical and basic research in the aforementioned areas of NLUTD....
Canadian Urological Association guideline: Diagnosis, management, and surveillance of neurogenic lower urinary tract dysfunction - Full text | Canadian Urological Association Journal
Urodynamic Findings of Neurogenic Bladder | SpringerLink
Urodynamics (UDS) is the term used to describe testing and measurements of the function of the lower urinary tract and is the only method that can objectively assess dysfunction during bladder filling, storage, and emptying. UDS is a crucial component of the urologic...
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization - PubMed
The complex interaction between cancer cells and the immune microenvironment is a central regulator of tumor growth and the treatment response. Chemotherapy-induced senescence is accompanied by the senescence-associated secretion phenotype (SASP). However, the mechanisms underlying the regulation of …
Mouse Bone Marrow Cell Isolation and Macrophage Differentiation - PubMed
The rapid increase in the incidence of obesity contributes to a parallel increase in nonalcoholic steatohepatitis (NASH). Monocyte-derived macrophages, recruited from the bone marrow to the liver, promote NASH-related inflammation and fibrosis. In addition, adipose tissue macrophages (ATMs) release …
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence - PubMed
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence …
Inflammatory markers in saliva and urine reflect disease activity in patients with systemic lupus erythematosus - PubMed
Our investigation demonstrates that saliva is a novel alternative body fluid, with potential for surveillance of general DA in patients with SLE, but urine is more informative in patients with SLE with predominantly renal DA.
CSF-1-induced DC-SIGN+ macrophages are present in the ovarian endometriosis - PubMed
This is the first study on the role of DC-SIGN+ macrophages in the immune microenvironment of endometriosis. Further study of the mechanism and biological activities of CSF-1-induced DC-SIGN+ macrophages will enhance our understanding of the physiology of endometriosis.
Inflammation-Stimulated MSC-Derived Small Extracellular Vesicle miR-27b-3p Regulates Macrophages by Targeting CSF-1 to Promote Temporomandibular Joint Condylar Regeneration - PubMed
Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have been extensively studied in recent years. sEV contents change with the secreting cell state. When MSCs are exposed to an inflammatory environment, they release more functional growth factors, exosomes, and chemokines. …
Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages - PubMed
Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions but their contribution to human macrophage polarization remains unclear. The LXR pathway is enriched in pro-inflammatory macrophages from rheumatoid arthritis as well as in tumors-associated macrophages from h …
Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation - PubMed
The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of metastasis. Turbulent flow in the portal circulation promotes retention of PDAC shed circulating tumor cells (CTC) and myeloid-derived immuno …