Cheat sheet: DevOps glossary | The Enterprisers Project
DevOps continues to proliferate among organizations looking to add speed and flexibility to their software development process. As a leader, you’ll need to be able to discuss it with both technical and non-technical audiences. That means cutting through the hype and occasional confusion around DevOps concepts. Download our primer on the key terms IT and business leaders need to know.
What are lightning talks? | The Enterprisers Project
What is a lightning talk? What's the purpose of a lightning talk? How can you give a good one? How can lightning talks help agile leaders in special ways? Check out this advice
How to get more from agile: The power of individuals and interactions | The Enterprisers Project
Do your agile results leave you wanting? Consider this advice on strengthening relationships, setting priorities, improving time management, and optimizing leadership.
Chemical Linkers in Antibody-Drug Conjugates (ADCs) (RSC Publishing)
The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design.Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.
Creative Biolabs has developed antibody-drug conjugate (ADC) technology to generate precision medicines targeting specific surface antigens to fight diseases.
Vincerx—next-generation antibody–drug conjugates with enhanced therapeutic windows
Vincerx applies a modular approach in the development of antibody–drug conjugates by incorporating novel targeting and safety features. The company’s lead compounds exhibit high efficacies with minimal toxicities that are expected to improve therapeutic windows. Vincerx believes that partners with first-in-class antibodies, clinical stage antibodies or ADCs against promising targets will benefit from Vincerx’s next-generation payload-linker technologies.
Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market, 2019-2030
Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market, 2019-2030 Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market, 2019-2030 - Market research report and industry analysis - 13084685
Antibody–drug conjugates: Recent advances in linker chemistry - ScienceDirect
Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the…
Increasing the Potency of Antibody–Drug Conjugates
Novel linker technology may be critical to increasing the potency and effectiveness of ADCs, explains Philipp Spycher, Co-Founder and CEO of Araris Biotech.
Linker and Conjugation Technology; and Improvements - Antibody‐Drug Conjugates - Wiley Online Library
The crux of successful antibody-drug conjugates (ADCs) rests on an indomitable conjugation and linker system that securely attaches a drug payload to an antibody. Linker and conjugation technologies ...
Advances in Linker Technology: Improving the Safety and Efficacy of Antibody Drug Conjugates
The targeted delivery of cytotoxic drugs using antibody drug conjugates would not be possible without effective linkers to connect and then release the key chemical and biological materials.
Linker technologies for antibody-drug conjugates - PubMed
Antibody-drug conjugates (ADCs), which combine the specificity, favorable pharmacokinetics, and biodistribution of a monoclonal antibody (mAb) with the cytotoxic potency of a drug, are promising new therapies for cancer. Along with the development of monoclonal antibodies (mAbs) and cytotoxic drugs, …