Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain - PubMed
Tat is a major regulatory protein encoded by human immunodeficiency viral genome, which has been implicated in the pathogenesis of HIV infection, including neurologic complications associated with this disease. In addition, drug abuse has been identified as a major risk factor of HIV infection. We h …
An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS),particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for car …
ER stress and the unfolded protein response - PubMed
Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein. Many conformational diseases are caused by mutations in secretory proteins and reach from metabolic diseases, e.g. diabetes, to developmental and neurological diseases, e.g. Alzheimer's d …
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors - PubMed
Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools …
Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology - PubMed
Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotoni …
Augmented Hospitality: step into our world! | For Accor, #hospitality has never been about just a night in a hotel. It’s about infinite connected moments, whether you want to Live, Work, or Play.... | By Accor GroupFacebook | Facebook
For Accor, #hospitality has never been about just a night in a hotel. It’s about infinite connected moments, whether you want to Live, Work, or Play.
What is it that we enjoy about #travel?
Limitless experiences.
Augmented hospitality is about living limitless and challenging the barriers of the hospitality industry, whether it is by creating improved digital solutions for our guests, enabling workspitality worldwide, or creating essential partnerships that shape opportunities for our guests, heartists and partners. Our ambition is to change the world we live in and to create an interconnected ecosystem for hospitality. ✨ 🗺
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