Research

Methamphetamine (METH) is a potent psychostimulant highly used worldwide. Recent studies evidenced the involvement of METH in the breakdown of the blood-brain-barrier (BBB) integrity leading to compromised function. The involvement of the matrix metalloproteinases (MMPs) in the degradation of the ne …

Minocycline is currently under development as a neuroprotective agent in many different brain diseases. In more than a dozen experimental investigations in various models of brain injury, high doses of minocycline have been administered intraperitoneally. This report details new concerns with this r …

Repeated injections of methamphetamine (METH) cause degeneration of striatal dopaminergic nerve terminals. In the present study, we examined the effects of interferon-gamma (IFN-gamma) on METH-induced striatal neurotoxicity in mice. Intraperitoneal injection of IFN-gamma before METH injection signif …

Methamphetamine is a type of psychoactive drug. It is well known that neurotoxicity caused by Methamphetamine(METH) can damage the nervous system and lead to apoptosis and cell loss of dopaminergic neurons. ROCK2 is a prominent target for gene therapy because its inhibition has proved to have a prot …

Failure to find more substantial changes in transporter levels and neurocognitive function may be attributed to the length of time that MA users were abstinent (ranging from 3 months to more than 10 years, mean 3 years), although there were no correlations with length of abstinence. Persistent VMAT2 …

The abuse of the illicit drug methamphetamine (METH) is a major concern because it can cause terminal degeneration and neuronal cell death in the brain. METH-induced cell death occurs via processes that resemble apoptosis. In the present review, we discuss the role of various apoptotic events in the …

Reactive oxygen species (ROS) are implicated in amphetamine-initiated neurodegeneration, but the mechanism is unclear. Here, we show that amphetamines are bioactivated by CNS prostaglandin H synthase (PHS) to free radical intermediates that cause ROS formation and neurodegenerative oxidative DNA dam …

Methamphetamine (METH) is a potent inducer of dopamine (DA) release, and is toxic to DA neurons. It has been reported that the formation of free radicals is an early signaling event that mediates cell death caused by METH. Currently, studies suggest that the generation of free radicals by oxidative …

Several hypotheses regarding the mechanism underlying amphetamine-induced neurotoxicity have been proposed. One of them is based on the observation of free radical formation and oxidative stress produced by auto-oxidation of dopamine (DA). The formation of DA-related reactive oxygen species (ROS) su …

HIV infection confers an increased concurrent risk of MA-associated disability, particularly among HIV-infected persons without histories of immune compromise. Directed referrals, earlier HIV treatment, and compensatory strategies aimed at counteracting the effects of low cognitive reserve, neurocog …

Glutamate, the most abundant excitatory transmitter in the brain can lead to neurotoxicity when not properly regulated. Excitotoxicity is a direct result of abnormal regulation of glutamate concentrations in the synapse, and is a common neurotoxic mediator associated with neurodegenerative disorders …

Psychomotor stimulants such as methamphetamine (METH), amphetamine, and 3,4-metylenedioxymethamphetamine (MDMA or ecstasy) are potent addictive drugs. While it is known that their abuse could result in adverse health complications, including neurotoxicity, both the environmental conditions and activ …

Tat is a major regulatory protein encoded by human immunodeficiency viral genome, which has been implicated in the pathogenesis of HIV infection, including neurologic complications associated with this disease. In addition, drug abuse has been identified as a major risk factor of HIV infection. We h …

Biosynthesis and metabolism of endothelium-derived nitric oxide

An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS),particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide generation in disease states. This article describes the biology of ADMA and the implications for car …

Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein. Many conformational diseases are caused by mutations in secretory proteins and reach from metabolic diseases, e.g. diabetes, to developmental and neurological diseases, e.g. Alzheimer's d …

Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools …

Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotoni …

The No FEAR Act increases the accountability of federal departments and agencies for acts of discrimination or reprisal against employees.

Welcome to "Academic Brown", the 1st video in our Brown Noise: A Sonic Wellness Journey Sessions by Mindful Frequencies Lab. In this 1-hour video journey, viewers will experience the epitome of pure brown noise. Our "Academic Brown" noise wave was generated in-house at out lab which resulted in a spectral density that drops at a rate of 6 dB per octave, creating a rich and deep sound that effectively reduces stress and enhances focus. The visuals include the soothing and calming movement of brown waves, designed to help you relax even further. Whether you are a student, professional, or just seeking relaxation, "Academic Brown" is the ideal audio experience to help you find peace and tranquility. These series of sessions are designed for those looking for a natural way to reduce stress and anxiety, improve sleep and focus, and promote overall well-being. Whether you're looking for a soothing background noise to help you relax while you work or study, or a guided meditation to help you unwind before bed, this video is perfect for anyone looking to improve their mental and physical well-being. Subscribing to our channel will keep you updated with our latest videos, so make sure to hit the subscribe button or follow this link @mindfulfrequencieslab Brown noise is known for its ability to enhance focus, block out distractions, calm pets and provide relief for tinnitus, making it a versatile addition to any self-care or sleep routine. This video is suitable for use with or without headphones, and can help you: - Focus - Sleep - Mask tinnitus - Reduce your internal monologue for better concentration - Calm children, babies, and pets For a more peaceful sleep experience, check out the black screen version of this video here https://youtu.be/6SpuQ-6K-jU If you find the content helpful, share it with your friends and family! Start your journey to better focus and productivity today with Academic Brown!!! Disclaimer: Mindful Frequencies Lab channel provides brown noise videos for the purpose of relaxation and rejuvenation. While the use of these videos is generally considered safe, it is important to follow best practices while listening to them. It is recommended to start with low volume and gradually increase to your comfort level. Mindful Frequencies Lab channel and its creators are not responsible for any harm or injury resulting from the use of these videos. Listening to these videos is done at your own risk. Any Republication and Re-uploads are Strictly Prohibited. Sound designed by Mindful Frequencies Lab © ℗ 2023 Mindful Frequencies Lab All Rights Reserved. The sound recordings contained in this video are the property of Mindful Frequencies Lab and are protected by copyright laws. Unauthorized duplication, distribution, or use of these recordings is strictly prohibited and constitutes copyright infringement. Mindful Frequencies Lab reserves the right to take all necessary measures to protect its intellectual property rights. #tinnitusreleif #brownnoisesleep #brownnoisestudy #brownnoise #brownnoisemeditation #sleepingmusic #deepsleep #balckscreen #MindfulFrequenciesLab #Relaxation #ReduceStress #CalmingVisuals #BetterSleep #DeepRelaxation #Concentration #CalmBabies #SoothingSounds #EscapeStress #FocusBoost #NoiseBlocker #CalmingWaves #RejuvenationJourney

ADHD relief music for better concentration and focus. Use this study music to boost productivity and eliminate distractions.~ My other channels: Sub Bass Med...

Click here to Subscribe ➤ https://www.youtube.com/channel/UCakcbmpdEhEYNcM0WBmYtJQ?sub_confirmation=1 💙 How to Support Us 💙Become a Member: https://www.you...

Products Archive - Binaural Beats by Brain Anew

The HTTP 204 No Content success status response code indicates that a request has succeeded, but that the client doesn't need to navigate away from its current page.

Suggested text: Our website address is: https://www.brainanew.com.

I’m so glad you wanted this wonderful resource.

https://www.brainanew.com/yt/12/focus-binaural-beats⬆️ Free DOWNLOAD ⬆️At last, an alternate version of the popular "90 Minutes of Focused Studying" track --...

A great way to help focus an easily distracted mind, this mix of brown noise with pure ambient binaural tones can help you get in the study or focus zone.As ...