Research

Background Randomised controlled clinical trials are performed to resolve uncertainty concerning comparator interventions. Appropriate acknowledgment of uncertainty enables the concurrent achievement of two goals : the acquisition of valuable scientific knowledge and an optimum treatment choice for the patient-participant. The ethical recruitment of patients requires the presence of clinical equipoise. This involves the appropriate choice of a control intervention, particularly when unapproved drugs or innovative interventions are being evaluated. Discussion We argue that the choice of a control intervention should be supported by a systematic review of the relevant literature and, where necessary, solicitation of the informed beliefs of clinical experts through formal surveys and publication of the proposed trial's protocol. Summary When clinical equipoise is present, physicians may confidently propose trial enrollment to their eligible patients as an act of therapeutic beneficence.

International internet-based studies could be accessible by participants from various countries worldwide. However, the jurisdiction of research ethic…

Iowa’s Citizen Foster Care Review Boards (ICFCRB or FCRB) provide independent third-party citizen review of cases in the foster care system.

from academic files at 2 universities over 2 years. In the first year (2014), the universities had not implemented a requirement for participation in a commercial board review course. In the second year (2015), both universities required participation in the course. There were 116 students at Idaho State University and 85 students at the University of Utah. Results Multiple regression analyses with PANCE score as the outcome variable were conducted with number of days to PANCE, number of practice tests, location of review course, Physician Assistant Clinical Knowledge Rating and Assessment Tool (PACKRAT) II performance, first-time PANCE pass rates, and first-time PANCE scores. After controlling for demographics, PACKRAT II scores, and students' home university, the study found that participation in the board certification course did not seem to affect student performance on the PANCE (R2 change = 0.000, p = .728). Post hoc analysis revealed a significant main effect for number of tests (F(3,94) = 3.35, p = .022, JOURNAL/tjpae/04.03/01367895-201706000-00004/math_4MM1/v/2021-01-27T005314Z/r/image-tiff = 0.097). Although not statistically significant, differences between on-site and off-site attendance may be of practical significance. Conclusions There were no significant differences in PANCE performance of PA students who participated in a program-sponsored board review course and the performance of those who did not participate the previous year. We offer suggestions for future research to maximize the utility of a board review course....

Protects the rights and welfare of human research subjects recruited to participate in research activities conducted at CHOP Research Institute.

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Rush University’s Office of Research Affairs has two institutional review boards (IRBs) as part of its human research protections program (HRPP). Each IRB is equally constituted and reviews the same types and levels of research. Each IRB meets once a week, every week throughout the calendar year. All research studies, including those that may qualify for exemption, must be

The Treatment Intervention Advisory Committee (TIAC) was formed early in 2011 to support the Department of Health Services (DHS) in ensuring quality services are available to the citizens of Wisconsin.

The following applications and guidance documents are meant to assist new researchers in completing their IRB applications. PI permission has been obtained and PIs had the option of retaining their names on the application or removing identifying information. These sample applications are meant for training University researchers in completing a Montclair State University IRB application. For […]

Answer (1 of 5): Intervention Review Boards look at grant proposals to make sure that any proposed human subjects intervention has informed consent, is not harmful, and is consistent with a sound methodology. All projects that meet the federal definition of research with human subjects (45 CFR 46...

A single trial is complex, with numerous regulations, administrative processes, medical procedures, deadlines and specific protocol instructions to follow. And yet, there has existed no single-volume, comprehensive clinical research reference manual for investigators, medical institutions, and national and international research personnel to keep on the shelf as a ready reference to navigate through trial complexities and ensure compliance with U.S. Federal Regulations and ICH GCP until The Sourcebook for Clinical Research. An actionable, step-by-step guide through beginning to advanced topics in clinical research with forms, templates and checklists to download from a companion website, so that study teams will be compliant and will find all the necessary tools within this book. Additionally, the authors developed Display Posters for Adverse Events Plus Reporting and Medicare Coverage Analysis that can be purchased separately here: https://www.elsevier.com/books-and-journals/book-companion/9780128162422/order-display-posters. Moreover, The Sourcebook for Clinical Research contains clear information and guidance on the newest changes in the industry to keep seasoned investigators and staff current and compliant, in addition to providing detailed information regarding the most complex topics. This book serves as a quick, actionable, off-the-shelf resource to keep by your side at the medical clinic. Makes vital trial conduct information easy to understand and instructs on how to practically apply current Federal regulations and Good Clinical Practice (ICH GCP) Offers extensive guidance that is crucial for guaranteeing compliance to clinical research regulations during each step of the clinical research process Provides up-to-date and extensive coverage of beginning to advanced topics, and, step-by-step actions to take during exceptional circumstances, including compassionate use, emergency use, human subjects protections for vulnerable populations, and federal audits Furnishes a detailed clinical research Glossary, and a comprehensive Appendix containing ready-to-use forms, templates, and checklists for clinical trial personnel to download and begin using immediately. Written for the fast-paced clinic environment with action steps and forms in the book to respond to a research subject’s needs urgently and compliantly

The Cessation of Smoking Trial in the Emergency Department (COSTED) study demonstrates that a brief intervention including e-cigarette starter kits can significantly help smokers in emergency departments quit, offering a new avenue to tackle smoking rates and associated health inequalities.

Scientific Reports - Effect of CHST11, a novel biomarker, on the biological functionalities of clear cell renal cell carcinoma

Our study confirms that even a lower dose of drugs can induce a clinically useful result. This study confirms that the useful effect of mesotherapy is only partly due to the pharmacological action. Further randomized prospective studies are needed to standardize the technique in the various pain syn …

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Intradermal (ID) vaccination can offer improved immunity and simpler logistics of delivery, but its use in medicine is limited by the need for simple, reliable methods of ID delivery. ID injection by the Mantoux technique requires special training and ...

Intradermal Injection Because little systemic absorption of intradermally injected agents takes place, this type of injection is used primarily to produce a local effect, as in allergy or tuberculi…

Intradermal injection, often abbreviated ID, is a shallow or superficial injection of a substance into the dermis, which is located between the epidermis and the hypodermis. This route is relatively rare compared to injections into the subcutaneous tissue or muscle. Due to the more complex use, ID injections are not...