Research

Nature Communications - Computer-aided design of protein-ligand binding is important for the development of novel drugs. Here authors present an approach to use the recently re-parametrized...

Highest Pct of Team Pts Scored(NBA Playoff History) PCT PTS2021 Middleton/Giannis 79.1% 68-862001 Duncan/Daniels 79.0% 64-812005 Yao/McGrady 78.9% 60-76Talk about a dynamic duo 💪 pic.twitter.com/FBZTPNiT8R— CBS Sports HQ (@CBSSportsHQ) June 13, 2021

This article contains information about changing a depreciation-sensitive field in the Asset Book window in Fixed Asset Management in Microsoft Dynamics GP and in Microsoft Business Solutions - Great Plains 8.0.

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There is increasing evidence to support the role of various acute phase reactants as an adjunct to clinical judgement in the management of various infections. Procalcitonin is more specific in diagnosing bacterial infections and has a wider role in the ...

Senator Cardin (D-MD) proposed to dramatically scale back individual and corporate income taxes and finance that cut with his Progressive Consumption Tax.

Cellular & Molecular Immunology - Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Imaging is important for establishing a diagnosis of HCC. Several imaging modalities including ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), positron ...

[vc_row][vc_column width=”7/12″][vc_empty_space][vc_single_image image=”686″ img_size=”full” alignment=”right” el_class=”pure-img”][/vc_column][vc_column width=”5/12″][vc_column_text] Ebeam Systems PCT offers innovative and reliable electron beam (ebeam) systems for a multitude of industrial applications.  Our systems feature our patented, integrated shield roll design and the latest digital technology in high voltage power supplies.  Don’t see a standard ebeam system that will work for your application?  […]

BACKGROUND AND PURPOSE: A previous study demonstrated the need to use delayed acquisition rather than first-pass data for accurate blood-brain barrier permeability surface product (BBBP) calculation from perfusion CT (PCT) according to the Patlak model, but the optimal duration of the delayed acquisition has not been established. Our goal was to determine the optimal duration of the delayed PCT acquisition to obtain accurate BBBP measurements while minimizing potential motion artifacts and radiation dose. MATERIALS AND METHODS: We retrospectively identified 23 consecutive patients with acute ischemic anterior circulation stroke who underwent a PCT study with delayed acquisition. The Patlak model was applied for the full delayed acquisition (90–240 seconds) and also for truncated analysis windows (90–210, 90–180, 90–150, 90–120 seconds). Linear regression of Patlak plots was performed separately for the full and truncated analysis windows, and the slope of these regression lines was used to indicate BBBP. The full and truncated analysis windows were compared in terms of the resulting BBBP values and the quality of the Patlak fitting. RESULTS: BBBP values in the infarct and penumbra were similar for the full 90- to 240-second acquisition (95% confidence intervals for the infarct and penumbra: 1.62–2.47 and 1.75–2.41 mL ×100 g−1 × min−1, respectively) and the 90- to 210-second analysis window (1.82–2.76 and 2.01–2.74 mL × 100 g−1 × min−1, respectively). BBBP values increased significantly with shorter acquisitions. The quality of the Patlak fit was excellent for the full 90- to 240-second and 90- to 210-second acquisitions, but it degraded with shorter acquisitions. CONCLUSIONS: The duration for the delayed PCT acquisition should be at least 210 seconds, because acquisitions shorter than 210 seconds lead to significantly overestimated BBBP values.

BACKGROUND AND PURPOSE: A previous study demonstrated the need to use delayed acquisition rather than first-pass data for accurate blood-brain barrier permeability surface product (BBBP) calculation from perfusion CT (PCT) according to the Patlak model, but the optimal duration of the delayed acquisition has not been established. Our goal was to determine the optimal duration of the delayed PCT acquisition to obtain accurate BBBP measurements while minimizing potential motion artifacts and radiation dose. MATERIALS AND METHODS: We retrospectively identified 23 consecutive patients with acute ischemic anterior circulation stroke who underwent a PCT study with delayed acquisition. The Patlak model was applied for the full delayed acquisition (90–240 seconds) and also for truncated analysis windows (90–210, 90–180, 90–150, 90–120 seconds). Linear regression of Patlak plots was performed separately for the full and truncated analysis windows, and the slope of these regression lines was used to indicate BBBP. The full and truncated analysis windows were compared in terms of the resulting BBBP values and the quality of the Patlak fitting. RESULTS: BBBP values in the infarct and penumbra were similar for the full 90- to 240-second acquisition (95% confidence intervals for the infarct and penumbra: 1.62–2.47 and 1.75–2.41 mL ×100 g−1 × min−1, respectively) and the 90- to 210-second analysis window (1.82–2.76 and 2.01–2.74 mL × 100 g−1 × min−1, respectively). BBBP values increased significantly with shorter acquisitions. The quality of the Patlak fit was excellent for the full 90- to 240-second and 90- to 210-second acquisitions, but it degraded with shorter acquisitions. CONCLUSIONS: The duration for the delayed PCT acquisition should be at least 210 seconds, because acquisitions shorter than 210 seconds lead to significantly overestimated BBBP values.

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We determined the stability of the LiBH4/CeH2 composite system by dynamic pcT (pressure, composition, temperature) measurements by using different constant hydrogen flows and by extrapolating ln(pdes/p0) linearly to equilibrium at zero flow. During desorption, the reaction 6LiBH4 + CeH2 → 6LiH + CeB6 + 10H2 occurs, leading to a theoretical hydrogen capacity of the destabilized system of 7.4 mass %. Within the model used and by applying the Van ˈt Hoff equation, the following thermodynamic parameters were determined for the desorption: enthalpy of reaction ΔrH = (58 ± 3) kJ mol−1 H2 and entropy of reaction ΔrS = (113 ± 4) J K−1 mol−1 H2, leading to a decomposition temperature Tdec = (240 ± 32) °C at a hydrogen pressure of p0 = 1.01325 bar, compared with ΔrH = 74 kJ mol−1 H2 and ΔrS = 115 J K−1 mol−1 H2 (Tdec = 370 °C) for pure LiBH4.1

The identification significance of C-reactive protein (CRP) and procalcitonin (PCT) levels in the intensive care unit patients with combined infection and their prognostic effects of patients with sepsis was investigated. A total of 203 patients were divided into the sepsis (n=60) and the non-sepsis group (n=143). The predictive effects of CRP and PCT levels in patients in the intensive care unit on sepsis and their effects on the prognosis of patients with sepsis were analyzed. The results showed that CRP and PCT levels in patients in the sepsis were higher than those in the non-sepsis group (p0.05); CRP and PCT levels in patients surviving sepsis at 1 week after admission were significantly decreased compared with those at admission (p

Values of low density lipoprotein (LDL) and procalcitonin (PCT) levels in evaluating the condition and prognosis of patients with acute cerebral infarction (ACI) were investigated. According to the volume of cerebral infarction, 150 patients with ACI (observation group) were divided into the mild infarction group (n=50), moderate infarction group (n=50), and severe infarction group (n=50). Besides, another 50 healthy subjects were enrolled during the same period as the control group. The levels of serum LDL and PCT on admission and at the 1st, 3rd, 7th and 10th day after treatment were detected, which were compared with those in the control group. Ten days after treatment, patients were divided into two groups, the effective group and non-effective group, based on the clinical efficacy. The differences in LDL and PCT levels were compared between the two groups. After 1 month, the clinical efficacy was evaluated again, and the correlations of LDL and PCT levels with prognosis were analyzed. The levels of serum LDL and PCT in the observation group 1 day after admission were higher than those in the control group (P

The healing of an extraction socket involved a series of events including the formation of a coagulum that was replaced by (i) a provisional connective tissue matrix, (ii) woven bone, and (iii) lamellar bone and BM. During the healing process a hard tissue bridge--cortical bone--formed, which "close …

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SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. BBB : blood-brain barrier CBF : cerebral blood flow CBV : cerebral blood volume DSC : dynamic susceptibility contrast FDG-PET : fluorodeoxyglucose–positron-emission tomography K trans : volume transfer coefficient MRI : MR imaging MTT : mean transit time MVCP : microvascular cellular proliferation MVD : microvascular density PCT : perfusion CT PS : permeability surface-area product rCBV : regional cerebral blood flow ROI : region of interest rPSR : relative percentage signal recovery SDF-1 : stromal derived factor-1 TDL : tumefactive demyelinating lesion TVA : total vascular area VEGF : vascular endothelial growth factor WHO : World Health Organization

SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. BBB : blood-brain barrier CBF : cerebral blood flow CBV : cerebral blood volume DSC : dynamic susceptibility contrast FDG-PET : fluorodeoxyglucose–positron-emission tomography K trans : volume transfer coefficient MRI : MR imaging MTT : mean transit time MVCP : microvascular cellular proliferation MVD : microvascular density PCT : perfusion CT PS : permeability surface-area product rCBV : regional cerebral blood flow ROI : region of interest rPSR : relative percentage signal recovery SDF-1 : stromal derived factor-1 TDL : tumefactive demyelinating lesion TVA : total vascular area VEGF : vascular endothelial growth factor WHO : World Health Organization