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In the title mol-ecule, C23H29NO5, the central piperidine ring has a chair conformation. The planes of the two benzene rings are inclined each to other at 61.7 (1)°. The crystal packing exhibits no directional inter-actions only van der Waals contacts.

Eisai's news release LAUNCH OF “DEMENTIA SUPPORT” INSURANCE TO PROVIDE FOR DEMENTIA IN JAPAN is posted.

Phonemic awareness is the ability to hear, identify, and manipulate individual sounds-phonemes--in spoken words.

Purpose This multicenter, dose-escalation study evaluates the safety, pharmacokinetics, and efficacy of galiximab (anti-CD80 monoclonal antibody) in patients with relapsed or refractory follicular lymphoma. Patients and Methods Patients had follicular lymphoma that had relapsed or failed to respond to primary therapy; the majority (90%) presented with stage III or IV disease. Four weekly intravenous infusions of galiximab were administered at doses of 125, 250, 375, or 500 mg/m2. Results Thirty-seven patients received galiximab treatment and were evaluated for safety; 35 were assessable for response. Antibody infusions were safe and well tolerated with no dose-limiting toxicities. A total of 22 (60%) of 37 patients experienced adverse events related to galiximab. All but one of the events were grade 1 or 2; the most common were fatigue, nausea, and headache. Cytopenias were rare; only one patient experienced anemia and febrile neutropenia, which were unrelated to galiximab and resolved after treatment. No patient developed antigaliximab antibody formation. The mean serum half-life ranged from 13 to 24 days. The overall response rate was 11% (two complete responses and two partial responses). Time to best response was delayed (months 3, 6, 9, and 12). Twelve patients (34%) maintained stable disease. Nearly half of all patients (49%) had a decrease in indicator lesions. Two responders remain on study without progression (22 and 24.4 months). Conclusion The favorable safety profile of galiximab and evidence of single-agent biologic activity and dose-dependent pharmacokinetics support further evaluation of galiximab as a treatment for follicular lymphoma, possibly in combination with other lymphoma therapies.

James M. (“Jim”) Hussey has been a President or CEO of various health care and advanced technology related companies over the past +20 years...

In the title mol­ecule, C[23] H[29] NO[5] , the central piperidine ring has a chair conformation. The planes of the two benzene rings are inclined each to other at 61.7 (1)°. The crystal packing exhibits no directional inter­actions ...

Mitoxantrone (Novantrone®) is an anthracenedione agent used in the treatment of several types of cancer.

LifeSpan BioSciences currently sells 137 antibodies , 2 peptides , 22 ELISA Kits , 54 proteins specific for CTLA4 / CD152.

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

A series of novel 1,2,4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side chain were designed and synthesized based on the structure of lanosterol 14α-demethylase (CYP51). Their antifungal activities against eight human pathogenic fungi were evaluated in vitro by measuring the mini …

Professor, Mathematics & IPST & CSCAMM, University of Maryland at College Park - Cited by 1,080 - Applied Mathematics - Epitaxial Growth - Plasmonics/Electromagnetics - Statistical Mechanics - Quantum Dynamics

Origene.

SCHAUMBURG, Ill. — Generic drug maker Sagent Pharmaceuticals has appointed James Hussey as its president, the company said. Sagent said the board of directors' appointment of Hussey, 53, would be effective Monday. Hussey will be responsible for the company's commercial operations, including development, regulatory affairs, supply chain activities, sales, marketing and human resources.

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Origene. A GENE CENTRIC LIFE SCIENCE TOOLS COMPANY   OriGene Technologies was founded as a research tool company focused on the creation of the largest commercial collection...

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What is a drug target? And how many such targets are there? Here, we consider the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles we provide an estimation of the total number of current drug targets.