Review of the basic and clinical pharmacology of sulfobutylether-beta-cyclodextrin (SBECD). - PubMed - NCBI
Despite its use in commercially available drugs such as intravenous voriconazole, there is little known in the medical literature about the clinical pharmacology of the solubilizing agent, sulfobutylether-beta-cyclodextrin (SBECD). This paper summarizes all known data on SBECD pharmacokinetics and s …
Examining the dynamics of an agent in the tumor microenvironment can offer critical insights to the influx rate and accumulation of the agent. Intratu…
Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. - PubMed - NCBI
A series of novel 1,2,4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side chain were designed and synthesized based on the structure of lanosterol 14α-demethylase (CYP51). Their antifungal activities against eight human pathogenic fungi were evaluated in vitro by measuring the mini …
Professor, Mathematics & IPST & CSCAMM, University of Maryland at College Park - Cited by 1,080 - Applied Mathematics - Epitaxial Growth - Plasmonics/Electromagnetics - Statistical Mechanics - Quantum Dynamics
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Drugs, their targets and the nature and number of drug targets. - PubMed - NCBI
What is a drug target? And how many such targets are there? Here, we consider the nature of drug targets, and by classifying known drug substances on the basis of the discussed principles we provide an estimation of the total number of current drug targets.