Secret Sauce IMMINENT

The same Democrats complaining about this voted for this, and now they are all, "Ohnoes, our city sucks. How could this have happened?"

An historical retrospective of the major events in year 1913 both worldwide and in the Metro Washington Area.

Here at N.E.I.G.H., we develop and deliver life-enriching, educational activities that can bring empowerment, healing, and behavior improvement to those who need it most, including Active Military and Veterans.

Here's a quick preview of X-Stink-Shun, a Wild Puppet experience! From the Jim Henson company.

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Opinion of the United States Court of Appeals for the Tenth Circuit Nos. 03-1290 and 03-1378 [1]. of his offense level based on its f...

Smooth-On urethane and silicone mold rubber is used for candle making

Smooth-On Materials for Cosplay applications.

Capture and reproduce detail from the human body safely and accurately.

Make your own medical training aids or variety of custom and stock Prosthetics and Orthotics.

Make breakaway glass, realistic props and other special effects.

Techniques for developing your idea into a three dimensional physical representation.

Applications using sprayable materials and equipment.

Rubbers, plastics, foams, pigments, etc. for realistically reproducing wildlife.

Using silicone to create reusable vacuum bags for resin composite applications.

Unlike supramolecular self-assembly methods that can organize many distinct components into designer shapes in a homogeneous solution (e.g., DNA origami), only relatively simple, symmetric structures consisting of a few distinct components have been self-assembled at solid surfaces. As the self-assembly process is confined to the surface/interface by mostly nonspecific attractive interactions, an open question is how these interfacial interactions affect multicomponent self-assembly. To gain a mechanistic understanding of the roles of the surface environment in DNA origami self-assembly, here we studied the oligonucleotide-assisted folding of a long single-stranded DNA (ssDNA scaffold) that was end-tethered to a dynamic surface, which could actively regulate the DNA–surface interactions. The results showed that even weak surface attractions can lead to defective structures by inhibiting the merging of multiple domains into complete structures. A combination of surface anchoring and deliberate regulation of DNA–surface interactions allowed us to depart from the existing paradigm of surface confinement via nonspecific interactions and enabled DNA origami folding to proceed in a solution-like environment. Importantly, our strategy retains the key advantages of surface-mediated self-assembly. For example, surface-anchored oligonucleotides could sequence-specifically initiate the growth of DNA origamis of specific sizes and shapes. Our work enables information to be encoded into a surface and expressed into complex DNA surface architectures for potential nanoelectronic and nanophotonic applications. In addition, our approach to surface confinement may facilitate the 2D self-assembly of other molecular components, such as proteins, as maintaining conformational freedom may be a general challenge in the self-assembly of complex structures at surfaces.

Despite significant progress in our understanding and treatment of metastatic cancer, nearly all metastatic cancers are incurable. In this Review, we use breast cancer as a model to highlight the limitations and inconsistencies of our existing treatment paradigms for metastatic disease. In turn, we …

Dirty and unpleasant. Someone who does not regard themselves as clean. One who is tasteless and devours others around them blaming others for everything that is wrong in their life.