Adjusting for time‐dependent sensitivity in an illness‐death model, with application to mother‐to‐child transmission of HIV - Teeple - 2015 - Statistics in Medicine - Wiley Online Library
In mother-to-child transmission of HIV, identifying infected infants relies on a diagnostic test with imperfect sensitivity that is administered at scheduled visits. Under this scenario, a participan...
Non-parametric maximum likelihood estimation of interval-censored failure time data subject to misclassification | SpringerLink
Statistics and Computing - The paper considers non-parametric maximum likelihood estimation of the failure time distribution for interval-censored data subject to misclassification. Such data can...
Likelihood based inference for current status data on a grid: A boundary phenomenon and an adaptive inference procedure
In this paper, we study the nonparametric maximum likelihood estimator for an event time distribution function at a point in the current status model with observation times supported on a grid of potentially unknown sparsity and with multiple subjects sharing the same observation time. This is of interest since observation time ties occur frequently with current status data. The grid resolution is specified as cn−γ with c > 0 being a scaling constant and γ > 0 regulating the sparsity of the grid relative to n, the number of subjects. The asymptotic behavior falls into three cases depending on γ: regular Gaussian-type asymptotics obtain for γ < 1/3, nonstandard cube-root asymptotics prevail when γ > 1/3 and γ = 1/3 serves as a boundary at which the transition happens. The limit distribution at the boundary is different from either of the previous cases and converges weakly to those obtained with γ ∈ (0, 1/3) and γ ∈ (1/3, ∞) as c goes to ∞ and 0, respectively. This weak convergence allows us to develop an adaptive procedure to construct confidence intervals for the value of the event time distribution at a point of interest without needing to know or estimate γ, which is of enormous advantage from the perspective of inference. A simulation study of the adaptive procedure is presented.
The Taxanes, Vinca Alkaloids, and Their Derivatives | Harrison's Manual of Oncology, 2e | AccessHemOnc | McGraw-Hill Medical
Read chapter 3 of Harrison's Manual of Oncology, 2e online now, exclusively on AccessHemOnc. AccessHemOnc is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine.
Inhibition of De Novo Purine Biosynthesis and Interconversion by 6-Methylpurine in Escherichia coli
The inhibition of Escherichia coli strain B and strain W-11 by 6-methylpurine depended on the formation of 6-methylpurine ribonucleotide by the action of adenine phosphoribosyltransferase (AMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.7). 6-Methylpurine ...
Reproductive endocrinology research: Innovative solutions for improving reproductive health
Discover why the Sprague Dawley® rat has been by far the workhorse of reproductive endocrinology research and is traditionally used as the experimental model for the study of contraceptive agents.
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