SIMULATION OPTICS

SIMULATION OPTICS

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A numerical study of flow-induced noise in a two-dimensional centrifugal pump. Part I. Hydrodynamics - NASA/ADS
A numerical study of flow-induced noise in a two-dimensional centrifugal pump. Part I. Hydrodynamics - NASA/ADS
This paper is concerned with the simulation of the flow in a flat, `two-dimensional' laboratory centrifugal pump. The main concern of the study is the calculation of the flow-induced noise. The aim of the present paper is to develop a computationally simple and fast method which is capable of giving a useful estimate of the noise-generating `background-flow'. A companion paper describes the hydroacoustic part of the analysis. In the numerical flow model of the pump, the inlet is modelled by a point source and the blades of the impeller are covered with vortex elements with discrete, bound vortices. The casing is covered with source panels. Vortices are shed from the trailing edges of the impeller blades and convected with the streaming fluid in order to satisfy Kelvin's theorem. After computation of the velocity field, the fluid forces acting on the impeller blades are calculated by application of the unsteady Bernoulli equation. Some case studies of pump flows are presented. The acoustic properties of these flows is the subject of the second part of the paper.
·ui.adsabs.harvard.edu·
A numerical study of flow-induced noise in a two-dimensional centrifugal pump. Part I. Hydrodynamics - NASA/ADS
Experimental investigation on the flow-induced noise under variable conditions for centrifugal pumps - NASA/ADS
Experimental investigation on the flow-induced noise under variable conditions for centrifugal pumps - NASA/ADS
With extensively using of centrifugal pumps, noise generation in these pumps is increasingly receiving research attention in recent years. The noise sources in centrifugal pumps are mainly composed of mechanical noise and flow-induced noise. And the study of flow-induced noise has become a hotspot and important domain in the field. The flow-induced noise closely related to the inner pressure pulses and vibration of volute in pumps, therefore, it is necessary to research the interaction and mechanism among them. To investigate the relationships, a test system is designed which includes a test loop and a measurement system. The hydrophones and pressure sensors are installed on the outlet of the pump and vibration acceleration sensors are disposed on the pump body. Via these instruments, the signals of noise, pressure pulses and vibration are collected and analyzed. The results show that the level of flow-induced noise becomes smaller as the flow increment during low flow rate operations, and it is steadily close to the design point, then it increases with the growing of flow rate in high flow rate conditions. Furthermore, there are some similar peak points in the power spectrum charts of noise, pressure pulses and vibration. The broadband noise at low flow rate is mostly focused on the region of 0-40 times shaft frequency, which is mostly made by rotating stall and vortex; while the noise at high flow rate conditions is focused on the region of 60-100 times shaft frequency, which may be mostly made by cavitations. The proposed research is of practical and academic significance to the study of noise reduction for centrifugal pumps.
·ui.adsabs.harvard.edu·
Experimental investigation on the flow-induced noise under variable conditions for centrifugal pumps - NASA/ADS
Pressure pulsations in piping system excited by a centrifugal turbomachinery taking the damping characteristics into consideration - NASA/ADS
Pressure pulsations in piping system excited by a centrifugal turbomachinery taking the damping characteristics into consideration - NASA/ADS
Pressure pulsations excited by a centrifugal turbomachinery such as compressor, fan or pump at the blade passing frequency may cause severe noise and vibrations in piping system. Therefore, the practical evaluation method of pressure pulsations is strongly recommended. In particular, the maximum pressure amplitude under the resonant conditions should be appropriately evaluated. In this study, a one-dimensional excitation source model for a compressor or pump is introduced based on the equation of motion, so as to incorporate the non-linear damping proportional to velocity squared in the total piping system including the compressor or pump. The damping characteristics of the compressor or pump are investigated by using the semi-empirical model. It is shown that the resistance coefficient of the compressor or pump depends on the Reynolds number that is defined using the equivalent velocity of the pulsating flow. The frequency response of the pressure amplitude and the pressure distribution in the piping system can be evaluated by introducing the equivalent resistance of the compressor or pump and that of piping system. In particular, the relation of the maximum pressure amplitude in piping system to the location of the excitation source under resonant conditions can be evaluated. Finally, the reduction of the pressure pulsations by use of an orifice plate is discussed in terms of the pulsation energy loss.
·ui.adsabs.harvard.edu·
Pressure pulsations in piping system excited by a centrifugal turbomachinery taking the damping characteristics into consideration - NASA/ADS
Scopus preview - Scopus - 52 documents that cite: Experimental characterization of centrifugal pumps as an acoustic source at the blade-passing frequency
Scopus preview - Scopus - 52 documents that cite: Experimental characterization of centrifugal pumps as an acoustic source at the blade-passing frequency
Elsevier’s Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
·id.elsevier.com·
Scopus preview - Scopus - 52 documents that cite: Experimental characterization of centrifugal pumps as an acoustic source at the blade-passing frequency
Novobiocin, ノボビオシン; « New Drug Approvals
Novobiocin, ノボビオシン; « New Drug Approvals
Novobiocin ノボビオシン; Molecular FormulaC31H36N2O11 Average mass612.624 Da (3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamido)-8-methyl-2-oxo-2H-chromen-7-yloxy)-3-methox…
·newdrugapprovals.org·
Novobiocin, ノボビオシン; « New Drug Approvals
Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients - PubMed
Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients - PubMed
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global outbreak of disease. The antiviral treatment acts as one of the most important means of SARS-CoV-2 infection. Alteration of physiological characteristics in special populations …
·pubmed.ncbi.nlm.nih.gov·
Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients - PubMed
Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review - PubMed
Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review - PubMed
Objectives: This study aimed to identify alterations in pharmacokinetics in children on extracorporeal membrane oxygenation (ECMO), identify knowledge gaps, and inform future pharmacology studies. Data Sources: We systematically searched the databases MEDLINE, CINAHL, and Embase from e …
·pubmed.ncbi.nlm.nih.gov·
Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review - PubMed
Overview of therapeutic drug monitoring - PubMed
Overview of therapeutic drug monitoring - PubMed
Therapeutic drug monitoring (TDM) is the clinical practice of measuring specific drugs at designated intervals to maintain a constant concentration in a patient's bloodstream, thereby optimizing individual dosage regimens. It is unnecessary to employ TDM for the majority of medications, and it is us …
·pubmed.ncbi.nlm.nih.gov·
Overview of therapeutic drug monitoring - PubMed
Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology - PubMed
Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology - PubMed
The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administratio …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology - PubMed
Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring - PubMed
Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring - PubMed
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological ti …
·pubmed.ncbi.nlm.nih.gov·
Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring - PubMed
Techniques for Monitoring Drug Efficacy - PubMed
Techniques for Monitoring Drug Efficacy - PubMed
The efficacy of drugs can vary greatly between species and individuals. Establishing efficacious drug doses for a species requires integration of population pharmacokinetic and pharmacodynamic data into a dose-response curve. Unfortunately, these data sets are rarely available for exotic species. Th …
·pubmed.ncbi.nlm.nih.gov·
Techniques for Monitoring Drug Efficacy - PubMed
Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring - PubMed
Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring - PubMed
Although the monitoring of drug therapies based on the determination of drug concentrations in biological materials is certainly an important instrument for individualized dosing and dose adjustment with a broad variety of pharmaceuticals, its role is limited by the fact that it does not reflect pha …
·pubmed.ncbi.nlm.nih.gov·
Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring - PubMed
Drug-Induced Ototoxicity: Diagnosis and Monitoring - PubMed
Drug-Induced Ototoxicity: Diagnosis and Monitoring - PubMed
Ototoxicity diagnosis and management has historically been approached using a variety of methods. However, in recent years a consensus on useful and practical approaches has been developed through clinical guidelines of the American Speech Language Hearing Association, the American Academy of Audiol …
·pubmed.ncbi.nlm.nih.gov·
Drug-Induced Ototoxicity: Diagnosis and Monitoring - PubMed
Chromatographic methods in HIV medicine: Application to therapeutic drug monitoring - PubMed
Chromatographic methods in HIV medicine: Application to therapeutic drug monitoring - PubMed
HIV antiretroviral therapy spans several different drug classes, meant to combat various aspects of viral infection and replication. Many authors have argued the benefits of therapeutic drug monitoring (TDM) for the HIV patient including compliance assurance and assessment of appropriate drug concen …
·pubmed.ncbi.nlm.nih.gov·
Chromatographic methods in HIV medicine: Application to therapeutic drug monitoring - PubMed
Monitoring drug therapy - PubMed
Monitoring drug therapy - PubMed
Drug development has improved over recent decades, with refinements in analytical techniques, population pharmacokinetic-pharmacodynamic (PK-PD) modelling and simulation, and new biomarkers of efficacy and tolerability. Yet this progress has not yielded improvements in individualization of treatment …
·pubmed.ncbi.nlm.nih.gov·
Monitoring drug therapy - PubMed
Therapeutic drug monitoring in pregnancy - PubMed
Therapeutic drug monitoring in pregnancy - PubMed
Therapeutic drug monitoring (TDM) is commonly recommended to optimize drug dosing regimens of various medications. It has been proposed to guide therapy in pregnant women, in whom physiological changes may lead to altered pharmacokinetics resulting in difficulty in predicting the appropriate drug do …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic drug monitoring in pregnancy - PubMed
Biosensors and nanobiosensors for therapeutic drug and response monitoring - PubMed
Biosensors and nanobiosensors for therapeutic drug and response monitoring - PubMed
Therapeutic drug monitoring (TDM) is required for pharmaceutical drugs with dosage limitations or toxicity issues where patients undergoing treatment with these drugs require frequent monitoring. This allows for the concentration of such pharmaceutical drugs in a patient's biofluid to be closely mon …
·pubmed.ncbi.nlm.nih.gov·
Biosensors and nanobiosensors for therapeutic drug and response monitoring - PubMed
Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities - PubMed
Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities - PubMed
In the modern era of cancer treatment, with targeted agents superseding more traditional cytotoxic chemotherapeutics, it is becoming increasingly important to use stratified medicine approaches to ensure that patients receive the most appropriate drugs and treatment schedules. In this context, there …
·pubmed.ncbi.nlm.nih.gov·
Pharmacodynamic Therapeutic Drug Monitoring for Cancer: Challenges, Advances, and Future Opportunities - PubMed
Therapeutic drug monitoring and LC-MS/MS - PubMed
Therapeutic drug monitoring and LC-MS/MS - PubMed
LC-MS/MS is an increasingly important tool in therapeutic drug monitoring as it offers increased sensitivity and specificity compared to other methods, and may be the only viable method for quantifying drugs without natural chromophores or fluorophores. The choice of sample preparation method, colum …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic drug monitoring and LC-MS/MS - PubMed
Therapeutic drug monitoring of targeted anticancer therapy - PubMed
Therapeutic drug monitoring of targeted anticancer therapy - PubMed
New oral targeted anticancer therapies are revolutionizing cancer treatment by transforming previously deadly malignancies into chronically manageable conditions. Nevertheless, drug resistance, persistence of cancer stem cells, and adverse drug effects still limit their ability to stabilize or cure …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic drug monitoring of targeted anticancer therapy - PubMed