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SNEAKY SPERM THIEVES & BIOMEDICAL INCENTIVES
Potentiality of Q3 characterization of nanosystem: Surrogate data for obtaining a biowaiver - PubMed
A tremendous increase in the entry of drug delivery systems (DDSs) based on nanotechnology has been observed as a result of the ability of pharmaceutical nanotechnology to overcome the various drawbacks related to the first generation DDS. The patent period of these proprietary branded drugs gives i …
Potentiality of Q3 characterization of nanosystem: Surrogate data for obtaining a biowaiver - Mohan - 2021 - Drug Development Research - Wiley Online Library
Biopharmaceutics and Drug Disposition | Pharmacology Journal | Wiley Online Library
Biopharmaceutics and Drug Disposition | Pharmacology Journal | Wiley Online Library
Biopharmaceutics and Drug Disposition is a top cited pharmacology journal publishing developments in the biopharmaceutics, drug disposition, pharmacokinetics, and pharmacodynamics field.
Biopharmaceutics and Drug Disposition | Pharmacology Journal | Wiley Online Library
Biopharmaceutics and Drug Disposition is a top cited pharmacology journal publishing developments in the biopharmaceutics, drug disposition, pharmacokinetics, and pharmacodynamics field.
Biopharmaceutics and Drug Disposition | Pharmacology Journal | Wiley Online Library
Biopharmaceutics and Drug Disposition is a top cited pharmacology journal publishing developments in the biopharmaceutics, drug disposition, pharmacokinetics, and pharmacodynamics field.
SciELO - Brazil - Interchangeability of medications and biopharmaceutical implication of taking drugs with fluids other than water: ibuprofen case study Interchangeability of medications and biopharmaceutical implication of taking drugs with fluids other than water: ibuprofen case study
Abstract The aim of this study was to compare the dissolution properties of ibuprofen solid oral...
gastrointestinal simulation biowaivers - Google Search
Applying GastroPlus Modeling Establish Level A IVIVCs Waive Biostudies - YouTube
Bioavailability/bioequivalence (BA/BE) evaluation by employing in vitro dissolution/release data and clinically relevant specification is required by the reg...
GastroPlus® PBPK & PBBM Modeling and Simulation
The GastroPlus® PBBM / PBPK modeling and simulation package - supporting internal research through regulatory filings. Clinical Pharmacology, PK/PD Analysis, Pharmacodynamics, Pharmacokinetics PKPD modeling
In Vivo Property Prediction | Oral Bioavailability | Volume of Distribution
The Simulation module in ADMET Predictor™ integrates the ACAT™ module to predict in vivo properties: High-throughput PK and more.
KNIME - Google Search
SpotFire® - Google Search
Development of a Novel Oral Cavity Compartmental Absorption and Transit Model for Sublingual Administration: Illustration with Zolpidem - PubMed
Intraoral (IO) delivery is an alternative administration route to deliver a drug substance via the mouth that provides several advantages over conventional oral dosage forms. The purpose of this work was to develop and evaluate a novel, physiologically based oral cavity model for projection and mech …
Pharmacokinetics of Biologics | PBPK Modeling of Large Molecules
Use the Biologics Module to easily create PBPK models and simulate the pharmacokinetics of biologics - for both mAbs and ADCs.
Drug Interactions | DDI Predictions | DDI Risk Assessment
GastroPlus Drug Drug Interactions workshop in Redwood City, CA - February 24-26, 2020 - Register Now!
IVIVC | Mechanistic IVIVC | In Vitro-In Vivo Correlation
IVIVCPlus Module makes it easy to mechanistically deconvolute dissolution profiles and create in vitro-in vivo correlations (IVIVC) - learn how it is used to support regulatory interactions.
Nonlinear Pharmacokinetics | PBPK Models | Drug Metabolism | Transport
The Metabolism and Transporter Module allows you to incorporate nonlinear pharmacokinetics into your PBPK models. Learn how your peers are using it.
Physiology Model | Deconvolution | Parameter Fitting | Model Building
GastroPlus is more than a simulation tool - learn how you can use the Optimization Module to build mechanistic absorption/PBPK models with observed data.
Incubator and Biotech Startup Package - Simulations Plus
Pharmaceutical Dosage Forms | In Vitro Dissolution Chemistry
Reimagine the dissolution of pharmaceutical dosage forms with DDDPlus. Learn more about our mechanistic models to simulate in vitro dissolution profiles.
MembranePlus Version 3.0 | Caco-2 Cells | In Vitro Permeability | Hepatocytes | Drug Transporters
MembranePlus simulates in vitro permeability (Caco-2, PAMPA, and MDCK cells) & hepatocyte assay studies. Learn how you can use it to unlock important info.
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Evaluating Utilization of Tiny-TIM to Assess the Effect of Food on the Absorptions of Oral Drugs and Its Application on Biopharmaceutical Modeling - Simulations Plus
Using Mechanistic Modeling Approaches to Support Bioequivalence Assessments for Oral Products - Simulations Plus
Using molecularly dissolved drug concentrations in PBBMs improves the prediction of oral absorption from supersaturating formulations - Simulations Plus
Exploring the impact of CYP2D6 and UGT2B7 gene-drug interactions, and CYP-mediated DDI on oxycodone and oxymorphone pharmacokinetics using physiologically-based pharmacokinetic modeling and simulation - ScienceDirect
Oxycodone is one of the most commonly used opioids to treat moderate to severe pain. It is metabolized mainly by CYP3A4 and CYP2D6, while only a small…
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human - Simulations Plus
Using Mechanistic Modeling Approaches to Support Bioequivalence Assessments for Oral Products | The AAPS Journal
The AAPS Journal - This report summarizes the proceedings for Day 1 Session 3 of the 2-day public workshop entitled “Best Practices for Utilizing Modeling Approaches to Support Generic...