SPERM STEM CELLS

Hematopoietic cell transplantation (HCT) data collection and analyzed by CIBMTR is available through related Web sites.

British researchers will study the genes of thousands of ill COVID-19 patients to try to crack one of the most puzzling riddles of the novel coronavirus: why does it kill some people but give others not even a mild headache?

Vedolizumab, an α4ß7 integrin IgG1 monoclonal antibody, has a favorable safety profile.1 However, data concerning the effect of vedolizumab exposure on male reproduction are limited.2 No study has investigated the impact of vedolizumab on semen quality, which is the standard surrogate marker of male fertility. The basic evaluation of sperm concentration, morphology, and motility does not evaluate the genomic integrity of the spermatozoa. Because intact DNA integrity is essential for the accurate transmission of paternal genetic information, examination of DNA integrity adds pivotal additional information to the conventional measures of semen quality.

Abstract. Factors associated with spermatogenesis after allogeneic hematopoietic stem cell transplantation (HSCT) were assessed in this prospective, single-cent

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Infectious viruses commonly are found in semen, with Zika being one recent notable example. The Chinese researchers noted that 27 different viruses have been detected in human semen.

This study compared vocal sound pressure level (SPL) and self-perception of speech and voice in men and women with idiopathic Parkinson disease (PD) and in healthy men and women. Thirty subjects wi...

After a bone marrow transplant, a man with leukemia found that his donor’s DNA traveled to unexpected parts of his body. A crime lab is now studying the case.

The Institut Pasteur has sequenced the whole genome of the coronavirus known as '2019-nCoV', becoming the first institution in Europe to sequence the virus since the start of the outbreak.

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A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for X-linked adrenoleukodystrophy

We study the effectiveness of information design in reducing congestion in social services catering to users with varied levels of need. In the absence of price discrimination and centralized...

Objective: To investigate the effects of sensory cueing with repetitive practice on hemiplegic arm functions in children with unilateral cerebral palsy. Design:...

Role of stem cells in fertility preservation: current insights

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Full result from the Cheung Sha Wan Handicap at Happy Valley

The prostate gland is a walnut-sized gland located near the bladder in male dogs. It surrounds the urethra, which is the long tube carrying urine from the bladder to the outside of the body. The prostate produces fluid that makes up...

A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for 5-alpha reductase deficiency

About 1 in 9 men will be diagnosed with prostate cancer in their lifetime. Does what you eat really affect your risk for prostate cancer? If you load up on veggies or love a good cup of coffee, you may be in luck. Learn more.

Background Hematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients. The treatment, however, is very costly, particularly in the context of low and middle income countries, and no studies have been carried out to explore its economic justifiability. This study aimed to estimate the cost-utility of HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for severe thalassemia in Thailand, and to investigate the affordability of HSCT using a budget impact analysis. Methods A Markov model was used to estimate the relevant costs and health outcomes over the patients' lifetimes taking a societal perspective as recommended by Thailand's health technology assessment guidelines. All future costs and outcomes were discounted at a rate of 3% per annum. Primary outcomes of interest were lifetime costs, quality adjusted life years (QALYs) gained, and the incremental cost-effectiveness ratio (ICER) in Thai baht (THB) per QALY gained. Results Compared to BT-ICT, the incremental cost-effectiveness ratio increased with patient age from 80,700 to 183,000 THB per QALY gained for related HSCT and 209,000 to 953,000 THB per QALY gained for unrelated HSCT among patients aged 1 to 15 years (US$1= 34 THB). The governmental budget impact analysis showed that providing 200 related HSCT to patients aged 1 to 10 years, in accordance with the current infrastructure limitations, would initially require approximately 90 million additional THB per year. Conclusions At a societal willingness to pay of 100,000 THB per QALY gained, related HSCT was likely to be a cost-effective and affordable treatment for young children with severe thalassemia in Thailand.

Scientists have analyzed every possible mutation to one key part of the coronavirus. The data could help guide vaccine and drug development and hint at how the virus might spread.

Myelofibrosis is one of the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms with heterogeneous clinical course. Though many treatment options...