This is the first study to demonstrate the effect of open-label placebos in improving well-being and sleep quality and to show that open-label placebo reposes do not appear to be dose-dependent, but for most well-being outcomes are independently predicted by both positive expectancies and treatment …

Kihlbom has recently argued that a system of seeking negatively informed consent might be preferable in some cases to the ubiquitous informed consent model. Although this theory is perhaps not powerful enough to supplant informed consent in most settings, it lends strength to Evans' and Hungin's pro …

Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects t…

Previous studies of mouse embryos concluded that after the optic vesicle evaginates from the ventral forebrain and contacts the surface ectoderm, sign…

Plasmid pLEX_307 from Dr. David Root's lab is published in Unpublished This plasmid is available through Addgene.

To achieve long-term viral remission in human immunodeficiency virus (HIV)-infected children, novel strategies beyond early antiretroviral therapy (ART) will be necessary. Identifying clinical predictors of the time to viral rebound upon ART interruption will streamline the development of novel therapeutic strategies and accelerate their evaluation in clinical trials. However, identification of these biomarkers is logistically challenging in infants, due to sampling limitations and the potential risks of treatment interruption. To facilitate the identification of biomarkers predicting viral...

To achieve long-term viral remission in human immunodeficiency virus (HIV)-infected children, novel strategies beyond early antiretroviral therapy (ART) will be necessary. Identifying clinical predictors of the time to viral rebound upon ART interruption will streamline the development of novel therapeutic strategies and accelerate their evaluation in clinical trials. However, identification of these biomarkers is logistically challenging in infants, due to sampling limitations and the potential risks of treatment interruption. To facilitate the identification of biomarkers predicting viral...

The Casework Direct System protocol entails a simple and rapid lysis of the sample, requiring no tube-to-tube transfers or DNA binding steps, producing a lysate compatible with RT-PCR quantification and PowerPlex STR amplification systems.

Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process. Heterogeneous expression of TM has been observed in cancer, and low or no TM expression in cancer cells is associated with poor prognosis. In th …

The Wizard® SV Genomic DNA Purification System provides a fast, membrane-based method for preparing genomic DNA from cultured cells and tissue, including mouse tails.

The pGEM®-T Vector Systems are convenient TA vector systems for quickly cloning PCR products.

The Molecular Biology Lab Guide is a resource designed for scientists just embarking on their career. The Guide focuses on fundamental technologies and techniques to provide an overview of the work you might encounter in a molecular biology research setting.

JM109 E. coli competent cells for blue/white screening, recombinant plasmid transformation and subcloning.

This DNA purification chapter addresses general information on the basics of DNA isolation, plasmid growth and DNA quantitation as well as how purification by silica can help increase your productivity so you spend less time purifying DNA and more time developing experiments and analyzing data.

Dr. Lutz Roewer is one of the renowned forensic scientists who transformed DNA forensics through studying the Y-chromosome and demonstrating the value of Y-STR analysis for forensic casework. I had the pleasure of interviewing Dr. Roewer while attending Promega’s 20th European Forensic DNA Working Group Meeting in Hamburg, Germany in November 2019.