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Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

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Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

Intelligent search from Bing makes it easier to quickly find what you’re looking for and rewards you.

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The ADA Home Page provides access to Americans with Disabilities Act (ADA) regulations for businesses and State and local governments, technical assistance materials, ADA Standards for Accessible Design, links to Federal agencies with ADA responsibilities and information, updates on new ADA requirements, streaming video, information about Department of Justice ADA settlement agreements, consent decrees, and enforcement activities and access to Freedom of Information Act (FOIA) ADA material

Academia.edu is a platform for academics to share research papers.

The U.S. Access Board is a federal agency that promotes equality for people with disabilities through leadership in accessible design and the development of accessibility guidelines and standards for the built environment, transportation, communication, medical diagnostic equipment, and information technology.

SAMSON AG

HIV-associated neurocognitive disorder (HAND) remains highly prevalent in HIV infected individuals and represents a special group of neuropathological disorders, which are associated with HIV-1 viral proteins, such as transactivator of transcription (Tat) protein. Cocaine abuse increases the incidence of HAND and exacerbates its severity by enhancing viral replication. Perturbation of dopaminergic transmission has been implicated as a risk factor of HAND. The presynaptic dopamine (DA) transporter (DAT) is essential for DA homeostasis and dopaminergic modulation of the brain function including cognition. Tat and cocaine synergistically elevate synaptic DA levels by acting directly on human DAT (hDAT), ultimately leading to dysregulation of DA transmission. Through integrated computational modeling and experimental validation, key residues have been identified in hDAT that play a critical role in Tat-induced inhibition of DAT and induce transporter conformational transitions. This review presents current information regarding neurological changes in DAT-mediated dopaminergic system associated with HIV infection, DAT-mediated adaptive responses to Tat as well as allosteric modulatory effects of novel compounds on hDAT. Understanding the molecular mechanisms by which Tat induces DAT-mediated dysregulation of DA system is of great clinical interest for identifying new targets for an early therapeutic intervention for HAND.

A growing number of people think they’re being tracked by unseen forces and tortured with strange devices. And increasingly, reality matches up to their worst fears.

SBIRT: Screening, Brief Intervention, and Referral to Treatment for Substance Use