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HIV-associated neurocognitive disorder (HAND) remains highly prevalent in HIV infected individuals and represents a special group of neuropathological disorders, which are associated with HIV-1 viral proteins, such as transactivator of transcription (Tat) protein. Cocaine abuse increases the incidence of HAND and exacerbates its severity by enhancing viral replication. Perturbation of dopaminergic transmission has been implicated as a risk factor of HAND. The presynaptic dopamine (DA) transporter (DAT) is essential for DA homeostasis and dopaminergic modulation of the brain function including cognition. Tat and cocaine synergistically elevate synaptic DA levels by acting directly on human DAT (hDAT), ultimately leading to dysregulation of DA transmission. Through integrated computational modeling and experimental validation, key residues have been identified in hDAT that play a critical role in Tat-induced inhibition of DAT and induce transporter conformational transitions. This review presents current information regarding neurological changes in DAT-mediated dopaminergic system associated with HIV infection, DAT-mediated adaptive responses to Tat as well as allosteric modulatory effects of novel compounds on hDAT. Understanding the molecular mechanisms by which Tat induces DAT-mediated dysregulation of DA system is of great clinical interest for identifying new targets for an early therapeutic intervention for HAND.

A growing number of people think they’re being tracked by unseen forces and tortured with strange devices. And increasingly, reality matches up to their worst fears.

SBIRT: Screening, Brief Intervention, and Referral to Treatment for Substance Use

77 FREE RISK ASSESSMENT FORMS, TEMPLATES, CHECKLISTS and APPS Top 10 Simple Things You Can Do To Dramatically Improve Safety TODAY!! You will probably not find many of these in text books or regula…

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Posts about Targeted Individuals in San Diego, CA written by maat433

Cross Platform React Native UI Toolkit

Cupertino, Calif. – Jun 27, 2006 Rinspiration Used Pre- and Post-Intervention In A Total Occlusion to Revascularize Blood Flow In 73-Year Old Patient The continued success of the Kerberos Peripheral Rinspiration® Catheter System in multi-device treatment interventions was one of … Learn more ›

Workshop on Mental Health Research Issues in HIV Infection and Aging co-sponsored by the Office of Rare Diseases at NIH

Excitation-wavelength-dependent (Ex-De) emission materials show excellent potential in diverse advanced photonic areas. Of significant importance is the on-demand regulation of the Ex-De luminescence behavior of these materials, which is previously unprecedented. In this study, we report on a platinum(II) complex-based phosphorescent soft salt S1 ([Pt(tpp)(ed)]+[Pt(ftpp)(CN)2]− (where ttp = 2-(4-(trifluoromethyl)phenyl)pyridine, ed = ethane-1,2-diamine, and ftpp = 2-(4-fluoro-3-(trifluoromethyl)phenyl)pyridine)) with Ex-De photoluminescence (PL) property. UV–visible absorption and PL spectra of S1 were recorded in DMSO–H2O mixture (1 × 10–3 M) with various H2O fractions to investigate its ground and excited states. Interestingly, the PL spectra of S1 powder show that its maximum emission peak is red-shifted from 595 to 644 nm upon excitation at different wavelengths from 360 to 520 nm, accompanied by an obvious emission color change from yellow-orange to red. Furthermore, confocal laser scanning fluorescence microscopy was employed to determine the PL property of self-assembled uniform S1 nanostructure, and the result shows that the Ex-De emission behavior is absent. On the basis of these results, we conclude the various Pt(II)···Pt(II) distances that exist are the major factor responsible for the properties of the Ex-De PL of S1 powder. Thus, for the first time, reversible on–off switching of Ex-De PL of S1 was achieved by manipulating its Pt(II)···Pt(II) distances through mechanical stress and vapor fuming. Finally, we demonstrate the high-level anticounterfeiting applications via on-demand multicolor displays.

Low back exercise plus health education may be the best approach to reduce NSCLBP in nurses. Considering the heterogeneity, our findings need to be confirmed in future multicenter large sample RCTs in different countries.

This model offers a platform to assess the risk of readmission for different populations with CHF and can assist clinicians with personalized treatment recommendations.

Comparison of HIC in one previous second-trimester pregnancy loss group with HIC in the 2 or more previous second-trimester pregnancy loss group found no difference in pregnancy outcome. This finding supports the amended ACOG guideline for HIC indications. Based on our results, we also propose devel …

Drug abuse (e.g., methamphetamine-Meth or cocaine-Coc) is one of the major risk factors for becoming infected with HIV-1, and studies show that in combination, drug abuse and HIV-1 lead to significantly greater damage to CNS. To overcome these issues, we have developed a novel nanoformulation (NF) f …

A co-founder of V2K HELPER Foundation, based in Venice, says tensions are high and his group needs financial backing from the community to help prevent gang violence.

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