WE ARE THE GANGSTALKERS

This blog is an attempt to spread awareness about the brutal but little known crime of gang stalking, or organized stalking, and the U.S. Federal Government's alleged reported involvement in d…

For me – Organized Harassment began in December 2012. Some tactics used on me : Mobbing Chemical Harassment Convoys Traffic Manipulation Vandalism Directed Conversations Manipulated Conflict …

Regenerative nanotechnology in oral and maxillofacial surgery Kaveh Shakib , Aaron Tan , Vukic Soskic and Alexander M. Seifalian British Journal of Oral and Maxillofacial Surgery, 2014-12-01, Volume 52, Issue 10, Pages 884-893, Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons Abstract Regenerative nanotechnology is at the forefront of medical research, and…

(2020). Current strategies to enhance the targeting of polydopamine-based platforms for cancer therapeutics. Journal of Drug Targeting: Vol. 28, No. 2, pp. 142-153.

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

We present a thoroughgoing electron paramagnetic resonance investigation of polydopamine (PDA) radicals using multiple electron paramagnetic resonance techniques at the W-band (94 GHz), electron nuclear double resonance at the Q-band (34 GHz), spin relaxation, and continuous wave measurements at the X-band (9 GHz). The analysis proves the existence of two distinct paramagnetic species in the PDA structure. One of the two radical species is characterized by a long spin–lattice T1 relaxation time equal to 46.9 ms at 5 K and is assigned to the radical center on oxygen. The obtained data revealed that the paramagnetic species exhibit different electron spin relaxation behaviors due to different couplings to local phonons, which confirm spatial distancing between two radical types. Our results shed new light on the radical structure of PDA, which is of great importance in the application of PDA in materials science and biomedicine and allows us to better understand the properties of these materials and predict their future applications.

Synthesis of Polydopamine Nanoparticles for Drug Delivery Applications - Volume 24 Issue S1

Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials, which enable spatiotemporal orchestration of various immunological events for mounting a highly potent and long-lasting ant …

A 25-kDa antioxidant enzyme that provides protection against oxidation systems capable of generating reactive oxygen and sulfur species has previously been identified. The nature of the oxidant eliminated by, and the physiological source of reducing equivalents for, this enzyme, however, were not kn …

The average functioning individual does not have a lot to be logically paranoid about. Sure, there's the occasional whisper that you overhear and think is about yourself. There's also the fear that someone is following you. Then there is gang stalking.

The sea urchin egg is a quiescent cell...until fertilization, when the egg is activated. The classic respiratory burst at fertilization is the result of prodigious hydrogen peroxide production, but the mechanism for this synthesis is not known. Here we quantitate the kinetics of hydrogen peroxide sy …

In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS)-configured decahydroquinoxalines 5-8 was developed. Physicochemical and pharmacological properties were fine-tuned by structural modifications in the arylacetamide and amine …

The University of Colorado Department of Obstetrics and Gynecology is committed producing innovative research and educating future clinicians and leaders in the areas of women's health, including gynecological cancer, reproductive medicine, urogynecology, transgender health, family planning and maternal-fetal medicine.

Polydopamine (PDA) is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation. Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent fr

Antioxidative therapy has been considered an efficient strategy for the treatment of a series of excessive reactive oxygen species (ROS)-triggered diseases, including oxidative-stress-induced periodontal disease. However, current natural enzymes and nanozymes often show their high specificity toward …

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Newly made hybrid nanosensors measured thermal conductivity in cells to be about one-sixth of that in water.

Nature Reviews Materials - The field of DNA nanotechnology takes the DNA molecule out of its biological context and uses its information to assemble structural motifs and connect these motifs...

Improving cycle stability of Si anode through partially carbonized polydopamine coating

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