Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics - PubMed
Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient and integrated phototheranostic nanoagents for amplifying PA imaging and PTT treatments poses great challe …
Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating l...
Polydopamine-Mesoporous Silica Core-Shell Nanoparticles for Combined Photothermal Immunotherapy - PubMed
Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials, which enable spatiotemporal orchestration of various immunological events for mounting a highly potent and long-lasting ant …
Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis - PubMed
Antibiotic-resistant bacteria is a major threat to human health and is predicted to become the leading cause of death from disease by 2050. Despite the recent resurgence of research and development in the area, few antibiotics have reached the market, with most of the recently approved antibiotics c …
The Path to Predictive Analytics and Machine Learning [Book]
In many companies today, discussions about predictive analytics and machine learning tend to overlook one critical component: implementation. This report will help you examine practical methods for building and deploying … - Selection from The Path to Predictive Analytics and Machine Learning [Book]
iTRAQ‐based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells - Fu - - Journal of Clinical Laboratory Analysis - Wiley Online Library
HNRNPA1 acts as targets downstream of FASN and potential biomarker and oncogene in OS.
The Benefits of Naming Rights Sponsorship — Bonham/Wills
Why Naming Rights? This is a question we often get from prospective corporate sponsors who are curious about this growing trend in the sponsorship world. This week's post highlights what many corporate sponsors and sports and entertainment properties find attractive abo
Embraced by Our Divine Mercy: During prayer, I heard these words: " My daughter, let your heart be filled with joy. I, the Lord, am with you. Fear nothing. You are in My heart." At that moment, I knew the great majesty of God and I understood that nothing could be compared with one single perception of God. ....The Lord has poured such a depth of peace into my soul that nothing will disturb it anymore. Despite everything that goes on around me, I am not deprived of my peace for a moment. Even if the whole world were crumbling, it would not disturb the depth of the silence which is within me and in which God rests. All events, all the various things which happen are under His foot. - St. Faustina
Jesus, I Trust In You "By far, these simple words spoken is the most efficacious, most yielding prayer we have ever encountered. Yet truly, it remains the antidote to any problem, any concern, any fear or anxiety. Jesus, I trust in You."
November 1. Another doubtful day dawns with the suggestions of a storm later on. I am to stay in anyhow, as Peter is coming to get me blogged and unstuck re spell check – with a bit of luck. After reading a few chapters of Teilhard’s book I can say, along with the missionary hiding in the jungle from a cannibal, there goes a man after my own heart. Pierre Teilhard was a Jesuit priest, philosopher, scientist, and palaeontologist, regarded as a genius by many scientists of various disciplines. It is always delightful to find a man of such standing echoing ones own thoughts or realizations, as I have enjoyed a few times while reading this book – and Hawking’s as well. This morning these words leaped off the page: Indeed, our sensory experience turns out to be a floating condensation on a swarm of the indefinable. Three cheers. Unfortunately, he did not elaborate, but left it at that, for which I excuse him as the subject was not the one under discussion. That said, I will elaborate for...
November 1. Another doubtful day dawns with the suggestions of a storm later on. I am to stay in anyhow, as Peter is coming to get me blogged and unstuck re spell check – with a bit of luck. …
/qresearch/ - Misuse of Israeli Surveillance Tech for Massive Violation of Human Rights
There is a criminal organization in Brazil using NSO Group's Pegasus to infect devices for hack for hire, to incite terrorism, blackmail people, produce illegal pornography and assist in assassinations. They also have other advanced malware, like UEFI implants and even persistent implants for Kindle and Raspberry Pi. Plus face/voice recognition on every camera and microphone they can get into, in public or private places.Brazil won't do anything to stop them. Only the FBI, CIA and NSA can stop them.There is also the possibility that they were engaged on the hack of Bezos' smartphone.If you ...
The field of DNA nanotechnology takes the DNA molecule out of its biological context and uses its information to assemble structural motifs and connect these motifs together. In this Review, a historical account of the field and the approaches used to assemble DNA nanostructures are outlined, followed by a discussion of emerging applications.
The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms and essential for the stability of long-lived cells in mammals. Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem …
Gastrointestinal synthetic epithelial linings | Science Translational Medicine
Orally delivered drugs are primarily absorbed in the small intestine, which is also the major site of nutrient absorption. Li and colleagues developed a versatile polydopamine-based solution that can coat and polymerize in situ in the small intestine. The synthetic coating adhered to pig and human tissue ex vivo, remaining stable for up to 24 hours. When administered to pigs endoscopically, polydopamine solution with suspended β-galactosidase increased digestive enzyme activity, whereas solution with embedded polydopamine nano–cross-linkers created a coating with transient barrier function ...
In situ measurements of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensors | Science Advances
Understanding heat dissipation processes at nanoscale during cellular thermogenesis is essential to clarify the relationships between the heat and biological processes in cells and organisms. A key parameter determining the heat flux inside a cell is the local thermal conductivity, a factor poorly investigated both experimentally and theoretically. Here, using a nanoheater/nanothermometer hybrid made of a polydopamine encapsulating a fluorescent nanodiamond, we measured the intracellular thermal conductivities of HeLa and MCF-7 cells with a spatial resolution of about 200 nm. The mean value...
Mussel-Inspired Surface Chemistry for Multifunctional Coatings | Science
We report a method to form multifunctional polymer coatings through simple dip-coating of objects in an aqueous solution of dopamine. Inspired by the composition of adhesive proteins in mussels, we used dopamine self-polymerization to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics. Secondary reactions can be used to create a variety of ad-layers, including self-assembled monolayers through deposition of long-chain molecular building blocks, metal films by electroless ...
Layered hydroxide/polydopamine/hyaluronic acid functionalized magnesium alloys for enhanced anticorrosion, biocompatibility and antithrombogenicity in vascular stents - Xiaojing He, Guannan Zhang, Yuliang Pei, Hongyu Zhang, 2020
Magnesium alloys are promising cardiovascular stent materials due to the favourable physical properties and complete biodegradability in vivo. However, the rapi...
OSA | Multi-layer optical fiber surface plasmon resonance biosensor based on a sandwich structure of polydopamine-MoSe2@Au nanoparticles-polydopamine
An all-optical fiber multi-layer surface plasmon resonance (SPR) biosensor based on a sandwich structure of polydopamine-MoSe2@Au nanoparticles-polydopamine (PDA-MoSe2@AuNPs-PDA) was designed for the detection of specific immunoreactions. By optimizing the multi-layer structure and the ratio of MoSe2: AuNPs, a sensitivity of 5117.59 nm/RIU has been obtained, which is more than double that of the only Au-filmed optical fiber SPR sensor. A large surface area was produced by integrating the MoSe2 primitive unit cell and the AuNPs into a hybrid plasmonic nanostructure of MoSe2@AuNPs, lea...
The therapeutic diagnosis effect of cancer commonly depends on the cellular uptake efficiency of nanomaterials. However, the morphology of nanomaterials significantly affects cellular uptake capability. Herein, we designed a polydopamine-doped virus-like structured nanoparticle (GNR@HPMO@PVMSN) composed of a gold nanorod (GNR) core, hollow periodic mesoporous organosilica (HPMO) shell and polydopamine-doped virus-like mesoporous silica nanoparticle (PVMSN) outer shell. Compared with conventional