US20100062074A1 - Allergen inactivating agent - Google Patents
An allergen inactivating agent for preventing allergic manifestations or alleviating symptoms by reducing antigenicity of an allergen through contact with the allergen includes dissolved chlorine dioxide as an active ingredient. "0]
For the concentration of chlorine dioxide that reduces the antigenicity of the allergen, from 0.05 ppm to 1 ppm is preferable, from 0.1 ppm to 1 ppm is more preferable, and from 0.1 ppm to 0.6 ppm is still more preferable. When the concentration is above 1 ppm, a safety problem may occur, and when below 0.05 ppm, effects as expected may not be obtained. Example of the forms of application include a nasal lavage fluid, collyrium, eye-drop, nasal solution (nasal spray), spray for throat, liniment for throat, and gargle. Specifically, it is possible to prevent allergic manifestations and alleviate allergic symptoms, by inactivating the allergen with the dissolved chlorine dioxide and washing down the allergen with the agent as wash solution, and thus by suppressing the amount of the allergen to a threshold or less. For example, an appropriate amount of the dissolved chlorine dioxide (aqueous solution of chlorine dioxide) having the concentration of from 0.1 ppm to 0.6 ppm may be applied externally as the nasal lavage fluid, collyrium, gargle or the like, 3 to 6 times per day." "to thereby obtain 1,000 ml of an aqueous solution of chlorine dioxide including chlorine dioxide gas dissolved therein, sodium chlorite, and sodium dihydrogenphosphate."