Health

The anticholinergics tolterodine and oxybutynin are well established in the management of overactive bladder. However, their activity at muscarinic receptors distant from the target site (i.e., bladder) produces anticholinergic side effects leading to poor tolerability. In 2004, trospium, solifenacin, and darifenacin were approved by the U.S. Food and Drug Administration for the treatment of overactive bladder. Trospium is water soluble and therefore is less likely to enter the central nervous system, and solifenacin and darifenacin are more selective for the bladder than older agents. Although these attributes could improve tolerability, clinical trials comparing relevant agents to validate this are lacking. Trials have shown that these newer agents decrease the frequency of incontinence episodes, the number of voids per day, and the number and severity of urgency episodes compared with placebo. These agents also have been shown to improve quality of life in women with overactive bladder and urinary incontinence. Head-to-head studies of the newer agents and immediate-release oxybutynin and tolterodine have suggested similar effectiveness across the class, although the newer agents are better tolerated. Trospium and darifenacin have not been compared with extended-release formulations of tolterodine or oxybutynin, which are better tolerated than the immediate-release versions. In one study, solifenacin produced a somewhat greater decrease in the number of incontinence episodes than extended-release tolterodine, with no difference in tolerability. In general, the newer agents appear to be at least as effective as their predecessors, although it is unclear whether they are better tolerated. Important pharmacokinetic differences among the agents (e.g., route of elimination) allow for selection of an appropriate agent based on individual factors such as cost and tolerability.

If you're stuck in what seems like an endless cycle of procrastination, guilt and chaos, you might be wondering,

Study Objectives: This pilot study determined whether transdiagnostic cognitive behavioral therapy for parasomnias (CBTp) reduces parasomnia and activity levels during sleep in a sample of adult sleep clinic outpatients. A secondary objective was to assess ...

Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) are two chemically related substances that have been studied for osteoarthritis. DMSO is used topically (applied to the skin). MSM is sold as a dietary supplement, either alone or in combination with other ingredients such as glucosamine.

Articles and discussions on Scratches Treatment Recipe written and moderated by an equine veterinarian.

Scientific Reports - DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

The muscles and nerves of the urinary system work together to hold and release urine at the right time. Nerves carry messages between the bladder and the spinal cord and brain. The messages tell the muscles of the bladder to either tighten or release. In neurogenic bladder, these nerves don’t work the way they should.

Dose equivalents of antipsychotics are an important but difficult to define concept, because all methods have weaknesses and strongholds.We calculated dose equivalents based on defined daily doses (DDDs) presented by the World Health Organisation’s ...

Over 100 different dietary supplement formulas have received the USP Verified Mark, representing several different brands and retailers. Here are three different ways you can find a quality supplement.

From pain relievers to heartburn medicine, these are the over-the-counter drugs and supplies you should have. Plus: what you should avoid as you age.

Learn how to identify penile thrush, what causes it, and what treatments to consider to avoid complications of this fungal yeast infection.

Folate deficiency occurs when your blood lacks the amount of folate it needs to function properly. Folate deficiency can cause a wide range of complications.

Learn about the potential side effects of imipramine. Includes common and rare side effects information for consumers and healthcare professionals.

Few movement disorders seem to make a straightforward approach to diagnosis and treatment more difficult and frustrating than myoclonus, due to its plethora of causes and its variable classifications. Nevertheless, in recent years, exciting advances have ...

Abilify MyCite (Aripiprazole Tablets with Sensor) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

Myoclonus is a fast, sudden muscle movement, like a twitch or jerk. It can be harmless and happen for normal reasons or it can be a symptom of a medical condition.

Neuroleptics, also known as antipsychotic medications, are medications that block dopamine receptors in the nervous system

Catatonia is a widespread problem in psychiatric hospitals as approximately 10% of patients present with catatonic symptoms upon admission. Catatonia carries the risk of severe, even fatal complications. The first line treatment is usually electroconvulsive therapy (ECT) or benzodiazepines, but ECT …

Sue Bohlin gives direction in helping teens think through LGBT feelings and behaviors from a compassionate, biblical Christian perspective.

Tryptophan is an amino acid that's a building blocks of protein and helps humans thrive. Eating tryptophan foods or taking supplements can help bring on natural calming effects, induces sleep, fights anxiety and even help with ADHD.

Hypernatremia (High Level of Sodium in the Blood) - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.

Anti-diuretic hormone acts to maintain blood pressure, blood volume and tissue water content by controlling the amount of water and hence the concentration of urine excreted by the kidney.

Taurine supplementation extends healthy lifespan in worms, rodents, and non-human primates.

supports immune health and nervous system function. daily intake of 500 and 1000 milligrams of taurine supplement per kg of body weight was also associated with improvements in strength, coordination, and cognitive functions.

Two patients with homocystinuria are discussed. Both patients presented with behavioural abnormalities and deficits in attention – symptoms that are frequently encountered in paediatric office practice. In both cases, the diagnosis of homocystinuria ...

Charles H. Surles DDS & Dentist Charles H. Surles, DDS in High Point NC offers Cosmetic Dentistry, 336-882-9820