Mouth & Nasal Uses

"found out the components within the Xlear nasal sprayTM, particularly grapefruit seed extract (GSE) and xylitol, were successful in statistically significant reduction of the viral load of SARS-CoV-" "5.9. Nasal Delivery of Hypochlorous Acid Hypochlorous acid (HClO), which is known as a potent broad-spectrum antibacterial agent, has shown strong antimicrobial (antibacterial, fungicidal or virucidal) effect in nasal formulations ... a unique Acid-Oxidizing solution (AOS2020) containing pure and stable HClO in a liquid carrier solution, using APR’s Tehclo™ nanotechnology delivery platform, which entraps HCLO in an aqueous solution, enabling its inhalation. AOS2020 comprises a hypotonic solution with unique physicochemical characteristics in terms of pH 2.5–3, oxidative reduction potential 1000–1200 mV and free chlorine species of which pure HClO is not less than 95%... The study involves COVID-19 patients with mild symptoms of the disease and aims at evaluating the efficacy and safety of the spray product in reducing viral load in the upper respiratory airways in recently infected individuals. Results, when available, could represent an additional near-term protective option that could be particularly helpful in high-risk environments."

Ivermectin is an FDA-approved broad-spectrum anti-parasitic agent that has been shown to inhibit SARS-CoV-2 replication in vitro.We aimed to assess the therapeutic efficacy of ivermectin mucoadhesive nanosuspension intranasal spray in treatment of patients ...

****!!!!**** "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, human coronavirus (HCoV) 229E, influenza A (H3N2), rhinovirus type 14, adenovirus type 5, and herpes simplex virus (HSV) type 1 and 2 were examined." "Stabilized chlorine dioxide containing ClōSYS® oral care products reduced the viral load of multiple viruses within 30 s."

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(2020). {***Click "Display Table" button for important dosing instructions***} " tolerability data-on-file (2017) shared by Sinox Pharma, Inc. show that a 0.008% (wt/vol %) ClO2 solution derived from ASC is nonirritating when administered as an intranasal cleanser to individuals with sub-clinical or clinical sinusitis." "more recent evaluations in animals and humans demonstrate that exposure to low concentrations of ASC or ClO2 (≤0.2% and 0.02%, [2000 ppm ASC and 200 ppm ClO2] respectively) such as those found to be effective in human mouth rinse studies are well tolerated" "Snoot™ (Sinox Pharma, Inc.) at the ‘Original’ strength. This formulation yields between 60 parts per million (ppm) and 75 ppm (~0.01% wt/vol) ClO2 over the course of 12 hours" "DioxiRinse™ (Frontier Pharmaceutical, Inc.) to be used at the ‘Standard Strength’ yielding a concentration of ~40 ppm (0.006% wt/vol) ClO2." "immediate cleansing using both products is suggested, even if the recommended maximum use of 4 times in a 12-hour period is exceeded. However, 6 administrations in a 24-hour period are strongly discouraged."

****!!!!****!!!!! "How the intervention might cause harm"

****!!!!*** {CloSYS chlorine dioxide}

The SARS-CoV-2 virus has given birth to several other new diseases. One of the rapidly spreading infection post-COVID recoveries is black fungus.

" It has been reported that some oral rinses, including those containing cetylpyridinium chloride, chlorine dioxide, and povidone-iodine, were able to decrease salivary load of the virus for up to six hours following use" " The results demonstrated that chlorine dioxide was more effective than other currently used oral rinses used as disinfectants with regard to aerobic bacteria and Candida yeast. Regarding anaerobes, chlorine dioxide’s efficacy was found to be similar to chlorhexidine. The biofilm-dissolving effect of chlorine dioxide is significantly greater when compared to chlorhexidine and Listerine. It was concluded that chlorine dioxide is a potent disinfectant with high efficacy on oral patho-genic microorganisms and a powerful biofilm-dissolving effect compared to the current antiseptic oral rinses."

****!!!!**** "We cannot be sure that such a treatment would be enough to prevent the development and spread of the illness, as viruses living in other parts of the body can survive. However, inactivating part of the viruses and reducing their load in the oropharyngeal region using Chlorine dioxide mouthwash would definitely aid the reducing the transmission of the disease through oral droplets along with the social distancing protocol. Chlorine dioxide mouthwash could augment the improvement of symptoms in COVID-19 patients as well." "A sample size of 40 patients was determined for the pilot study. Patients confirmed as positive for COVID-19 antigen by means of Qualitative PCR test with age ranging from 19 to 49 years were included in the study"

{Solonium chlorine dioxide product}

****!!!!****!!!!*** 2020 March

***** "The authors believe that the topical application of PVP‐I is safe and may help to reduce the viral load, and the potential aerosolization, of SARS‐CoV‐2. Until confirmatory studies are conducted, our institutional consensus is to dilute commonly available PVP‐I (typically 7.5%) 1:3 with saline to achieve a less than 2% concentration and bulb syringe the solution into the oral/nasal cavity, after intubation, but immediately prior to head and neck procedures that require instrumentation of the upper airway mucosa during the COVID‐19 pandemic. We suggest leaving the solution in for approximately 1 minute before irrigating with saline and suctioning it out to reduce residual absorption and limit tissue staining – though the optimal concentration and application time, if any, are currently unknown."

(2020). Acidified sodium chlorite solution in mouth rinse. (in addition to standard use of PPE)

"Snoot™ (Sinox Pharma, Inc.) at the ‘Original’ strength. This formulation ... yields between 60 parts per million (ppm) and 75 ppm (~0.01% wt/vol) ClO2 over the course of 12 hours," "DioxiRinse™ (Frontier Pharmaceutical, Inc.) to be used at the ‘Standard Strength’ yielding a concentration of ~40 ppm (0.006% wt/vol) ClO2. If an HCP has direct exposure to a cough or sneeze of individual with presumed COVID-19, immediate cleansing using both products is suggested, even if the recommended maximum use of 4 times in a 12-hour period is exceeded. However, 6 administrations in a 24-hour period are strongly discouraged."

****!!!!*** "hypothesis as to why ClO2 is safe even in higher concentrations when added to the dental unit waterlines in order to minimize the virus transmission through dental aerosols."

If the mist in a dentist's office -- sent flying into the air by spinning, vibrating tools -- contains a virus or some other pathogen, it is a health hazard. So researchers studied the viscoelastic properties of food-grade polymers and discovered that the forces of a vibrating tool or dentist's drill are no match for them. Not only did a small admixture of polymers completely eliminate aerosolization, but it did so with ease.