2020 "application of ClO2does not lead to a significant decrease in viability ofPLDSCs in concentrations used to kill microbes." "While the active ingredients of mouthwash (H2O2, CHX) applied in endodontic or periodontitis management have a serious toxic effect on PDLSCs, the novel hyperpure ClO2 is less toxic providing an environment favoring dental structure regenerations during disinfectant interventions."

2020 {Meta-analysis based on 5 randomised controlled trials} "Chlorine dioxide reduces both plaque and gingival indices and bacterial counts in the oral cavity similar to other routinely used oral rinses; however the evidence supporting this outcome is very limited. Therefore, further large scale RCTs are needed to decrease the risk of bias."

{Graph chowing ppm concentration of "free" chlorine dioxide over time after activation}

Oracare, but none of the other oral rinses, removes significants more VSCs produced by P. gingivalis than does water.

"The species to be tested are: Streptococcus mutans (UAI59), Lactobacillus acidophilus (ATCC 4356), Porphyromonas gingivalis (ATCC 33277), Aggregatibacter actinomycetemcomitans (ATCC 43718), Tannerella forsythia (ATCC 43037), Treponema denticola (ATCC 35405), Treponema socranskii (ATCC 35535), Prevotella intermedia (ATCC 49046), and Candida albicans (ATCC 64124). ...requested that Pseudomonas aeruginosa and Proteus mirabilis be added to the list of test species.” “The experimental Rinse exhibited broad spectrum anti-microbial activity against Gram-positive and Gram"-negative bacterial species common to the oral cavity', including cariogenic and periodontal pathogens, and against the opportunistic fungal pathogen C. albicans.“

Clinical improvement after periodontal tray application of chlorine dioxide gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis was studied for a period of 30 days.The tray fabrication was performed in ...

2014 "Twenty milliliters of each experimental solution, 0.16% sodium chlorite" "The sodium chlorite solution reduced the VSC concentration remarkably. After mixing, nearly all VSCs were eliminated immediately and no VSCs were detected at 30 and 60 min post-mixing." "The results suggest that sodium chlorite solution has the effect of eliminating gaseous VSCs directly. This must be because it can release chlorine dioxide gas which can react directly with gaseous VSCs. In the case of other solutions that have been proved to be effective to reduce halitosis clinically, it can be proposed that their anti-VSC effect is less likely due to the direct chemical elimination of gaseous VSCs in the mouth."

2013

" After rinsing with the mouthwash containing ClO2 for 7 days, morning bad breath decreased as measured by the OM and reduced the concentrations of H2S, CH3SH and (CH3)2S measured by GC, were found. Moreover ClO2 mouthwash used over a 7-day period appeared effective in reducing plaque, tongue coating accumulation and the counts of Fusobacterium nucleatum in saliva."

"The authors conducted a clinical trial involving 16 children ages 6–11 with at least 8 black-stained teeth. Subjects were randomized into 2 groups and instructed to rinse with chlorine dioxide or chlorhexidine mouthrinse twice daily. At baseline and after 7 days, samples of black stain plaque were collected, and Actinomyces sp. was cultured... After 7 days, Actinomyces sp. viability was remarkably reduced in both groups, and there was a significantly higher reduction in viability in the 0.1% chlorine dioxide group than there was in the 0.1% chlorhexidine group"

Blog articles including "DioxiCare Combo Helps People with Diabetes Maintain Oral Health", etc

"Highest concentration chlorine dioxide rinse. Kills all bacteria, virus and yeast in one minute in vitro (in the lab). Removes bad breath immediately by oxidation and is not a masking agent. Bad breath produced by volatile sulfur compounds (VSCs) and non sulfur compounds such as smoking odors are neutralized and removed. Only an oxidizing agent like DioxiRinse can accomplish both. Eliminates bad breath originating in the mouth, throat and tongue See bad breath removal results measured by a gas chromatograph. Effervescent formula penetrates gums, between the teeth, and around braces where bacteria hide. DioxiCare helps remove stains and biofilm. Relieves colds and sore throats. Used before and after implants and extractions. Used post laser perio-therapy. Excellent for mucositis Periodontists recommend chlorine dioxide mouthwash for infected gums" "The longer the mixture sits, the stronger it gets. No other mouthwash provides this feature."

People love Snoot! Spray when compared to Neti Pots, Saline Rinses, and other ineffective ways to fight mucus.

"DioxiRinse Mouthwash and DioxiBrite Toothpaste kill almost all bacteria and viruses within a minute. Typically, bactericidal testing is performed in vitro (in the lab). As most of us know, deactivating microorganisms within the body (in vivo) is quite a bit more difficult, especially when testing in the mouth, where organic material such as saliva and food protect the bacteria. In this video, a sample of saliva was tested for bacteria before and after rinsing with DioxiRinse Mouthwash. With a magnification of 500 times, one can see wiggling and vibrating bacteria before rinsing, indicating that the bacteria are alive. After briefly rinsing with DioxiRinse, wiggling and vibrations have stopped or are greatly reduced, indicating most of the bacteria are dead or in the process of dying."

***!!!*** {Lists significant negative effects caused by topical (including oral) applications of chlorhexidine}

Chromas

Tests against Klebsiella pneumoniae, and Fusobacterium nucleatum

"All virus was killed in one minute"

{Dioxident, which has 100 ppm ClO2??} " Patients were instructed to rinse the mouth with 0.8% [??] ClO2 mouth rinse (DioxiDent) twice daily for one minute and to soak their dentures overnight in the ClO2 for 10 days" "topical antiseptic for the treatment of chronic atrophic candidiasis in geriatric patients. Participants..."