--Includes comparison charts

**Includes pathogen levels. In another referenced study, ClōSYS safely reduced the exposure to microbial aerosols by 60%.

{Chlorine dioxide treatment}

While thereis no evidence that inactivating the COVID-19 virus in the mouth will impact disease transmission, the studiesreinforce the antimicrobial strength of ClōSYS products.Clinical trials in progress at the University of California San Francisco are evaluating whether oral rinses can reduce the viral load in the mouth, which mayin turn reduce the transmission of the disease.

Dentistry Today July/August 2020 Page 18

The aim of this study was to evaluate the effect of chlorine dioxide and various other more common irrigation solutions on the microhardness and surface roughness of root canal dentin. Fifty human maxillary central incisors were sectioned longitudinally and treated for 1 minute with 5 ml of the foll …

Chlorine dioxide whitens teeth at a faster rate than hydrogen peroxide. Specimens treated with chlorine dioxide were significantly lighter than those treated with hydrogen peroxide at the end of the first 2 min application cycle, however, extended exposures did not enhance color.

As the presence of dentin powder had a negative effect on the efficacy of disinfectants, the importance of elimination of dentin scrapings and smear layer from the root canal system during endodontic treatments is highly recommended. ClO 2 can be effective for a final rinse.

**** White Papers and Studies available on Frontier's Active Chlorine Dioxide Mouthwash, Toothpaste, Periodontal Gel, and other DioxiCare® products.

"Snoot™ (Sinox Pharma, Inc.) at the ‘Original’ strength. This formulation ... yields between 60 parts per million (ppm) and 75 ppm (~0.01% wt/vol) ClO2 over the course of 12 hours," "DioxiRinse™ (Frontier Pharmaceutical, Inc.) to be used at the ‘Standard Strength’ yielding a concentration of ~40 ppm (0.006% wt/vol) ClO2. If an HCP has direct exposure to a cough or sneeze of individual with presumed COVID-19, immediate cleansing using both products is suggested, even if the recommended maximum use of 4 times in a 12-hour period is exceeded. However, 6 administrations in a 24-hour period are strongly discouraged."

"The difference in effectiveness between the chlorine dioxide gas of Oracare and stabilized/precursor forms of chlorine dioxide (sodium chlorite) was evident as none of the mouthrinses using the latter inactivated significantly greater levels of VSCs than the water control." "The MICs for Oracare were higher than those for chlorhexidine when compared directly against a panel of 11 microbial species. However, when normalized to parts per million of the active ingredients, the Oracare rivaled the activity of chlorhexidine and exceeded it in activity toward the periodontal pathogen Aggregatibacter actinomycetemcomitans. The Oracare rinse removed a statistically higher percentage of VSCs than chlorhexidine"

The application of chlorine dioxide gel using the custom tray after SRP in the treatment of chronic periodontitis showed better clinical improvement in pocket depth reduction and bleeding index compared to SRP alone.

We investigated the effectiveness of chlorine dioxide (ClO2) solution in comparison to sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) in the elimination of intracanal Enterococcus faecalis biofilm. Extracted human teeth were inoculated with E. faecalis. After preparation the canals we …

The triple-inoculation bovine tooth model system is a robust, consistent, and reproducible model system to study polymicrobial biofilms. It should be used with the knowledge expansion of biofilm structure and function as well as the development of antimicrobial protocols.

This study investigated the ability of chlorine dioxide to eliminate Enterococcus faecalis from dentinal tubules of bovine incisors. Thirty-seven extracted bovine incisor roots were sectioned into seventy-four 5 mm disks. Standardized lumens were filled with either sterile Brain Heart Infusion Broth …

0.1% CD mouthwash

Dental professionals are concerned about microbial contamination resulting from airborne splatter from the patient’s mo

since it has a low pH, long-term exposure may harm teeth... Chlorine dioxide mouthwashes are available for purchase. If you use one, take special care not to swallow the solution, as the ***[Note: This concentration is actually safe for limited consumption, although is higher than concentration officially approved for drinking water] concentration of chlorine dioxide in these products is much higher than the threshold for safe consumption***

Treatment of periodontal (gum) disease may lessen the adverse consequences of some chronic systemic conditions.To estimate the effects of periodontal …

(2020). Acidified sodium chlorite solution in mouth rinse. (in addition to standard use of PPE)