mast cell/mcas

Hypercholesterolaemia and liver abnormalities are frequently found in patients with the mast cell activation syndrome. Hence, the mast cell activation syndrome should be considered at an early stage as a possible cause of hypercholesterolaemia and of hepatic abnormalities of unknown reason. Mast cel …

Do mast cells make you gain weight and have a huge stomach when you are eating almost nothing? I have seen MCAS drive weight gain in some patients, weight loss in other patients…

Citric acid as a food additive is not natural citric acid; it is manufactured through fermentation using Aspergillus niger. Aspergillus niger is a potent allergen. Food additive manufactured citric acid may be causing allergic inflammatory cascades. ...

Did you know that most meat purchased from the grocery store is very high in histamine levels? This is why many people that have mast cell activation syndrome (MCAS) or histamine intolerance don’t tolerate store-bought meats well.Even though store-bought meats are “fresh”, it has still likely been many days since they were slaughtered. Beef is almost always aged for 15-45 days (when you buy it from the store or a local farm). The longer meats are aged, the higher in histamines they become. Even

Information about treatment options for mast cell activation syndrome and mastocytosis

Using Histamine H1 and H2 blockers for the treatment of Mast Cell Activation Syndrome MCAS UK often bring clinically significant benefits.

Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). ...

Radiofrequency turbinate reduction is a procedure in which a needle-like instrument is inserted into the turbinate. Learn more here.

The increase in membrane fluidity by SNAC plays a pivotal role in the permeation enhancement mechanism of cromolyn sodium. Therefore, the increase in permeation is a result of changing Caco-2 cell membrane fluidity resulting in change in membrane integrity and not due to an increase in the lipophili …

Pharmacological efficacy of DSCG has been demonstrated in animals and humans. If the drug is delivered to the site of inflammation in an effective dose, a reliable therapeutic effect can be expected. DSCG has extra properties and potential unspecific antiviral properties and may offer new therapeuti …

Cell Death & Disease - Dopamine D3 receptor signaling alleviates mouse rheumatoid arthritis by promoting Toll-like receptor 4 degradation in mast cells

Persistent exposure to ambient fine particulate matter (PM2.5) can exacerbate allergic diseases in humans. Mast cells play an important role in allerg…

The FDA is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices; and by ensuring the safety of our nation's food supply, cosmetics, and products that products that emit radiation.

Allergen immunotherapy (AIT), including SCIT and SLIT, is a treatment that involves the administration of allergens to which patients with allergic di…

PDF | Objective: To investigate mast cell stabilizing potential of camel milk (Camelus dromedaries) in the management of asthma using experimental... | Find, read and cite all the research you need on ResearchGate

The activation of adenosine A2B receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evide…

Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic connective tissue diseases. The relationship between their occurrence in allergic diseases is poorly documented. However, the mechanism of allergic and autoimmune diseases ...

Our observations suggest most positive antibody tests in MCAS patients represent detection of clinically insignificant mimicking antibodies. As such, to reduce incorrect diagnoses of AADs and inappropriate treatment in MCAS patients, caution is warranted in interpreting positive antibody tests in th …

Author’s note: I am not a medical doctor. Anaphylaxis and use of epinephrine must be discussed with the managing provider to determine the best treatment plan for any individual patient.   Determination of mast cell reaction vs anaphylaxis Anaphylaxis has a very complicated relationship with mast cell disease. Mast cell symptoms and reactions are inherent… Read More »Anaphylaxis and mast cell reactions